Letztes “update” :
12/09/2024
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Stabilität von pharmazeutischen Präparaten
Stabilitätbeeinflussende Faktoren
Kompatibilitäten
A
-
B
-
C
-
D
-
E
-
F
-
G
-
H
-
I
-
J
-
K
-
L
-
M
-
N
-
O
-
P
-
Q
-
R
-
S
-
T
-
U
-
V
-
W
-
X
-
Y
-
Acetazolamide
316
Aciclovir sodium
1415
3595
Aciclovir sodium
301
1868
3595
Aciclovir sodium
3595
Aldesleukin
3635
Allopurinol sodium
307
Alteplase
3616
Aminophylline
316
Amiodarone hydrochloride
1733
Amiodarone hydrochloride
3524
Amiodarone hydrochloride
3379
Amiodarone hydrochloride
200
205
1611
3464
3823
Amoxicillin sodium
3527
Amoxicillin sodium
3527
Amoxicillin sodium
3527
Amoxicillin sodium
4211
Amoxicillin sodium
-20°C
427
598
Amoxicillin sodium / clavulanic acid
3545
Amoxicillin sodium / clavulanic acid
3545
Amoxicillin sodium / clavulanic acid
3545
Amoxicillin sodium / clavulanic acid
3545
Amoxicillin sodium / clavulanic acid
-20°C
1318
Amoxicillin sodium / clavulanic acid
25°C
2951
Amphotericin B
1172
3591
Amphotericin B
1172
3968
Amphotericin B
265
270
793
984
1498
2043
Amphotericin B
301
Amphotericin B
3591
Amphotericin B cholesteryl sulfate complex
921
Amphotericin B liposomale
3398
Amphotericin B liposomale
3398
Ampicillin sodium
3528
Ampicillin sodium
316
999
3528
Ampicillin sodium
-20°C
575
Anidulafungin
1982
Atenolol
pH = 4
1696
Atracurium besylate
657
Atracurium besylate
pH
pH >7
3629
Azacitidine
1039
Azasetron
4301
Aztreonam
2263
Baclofen
3683
Belimumab
3936
Bendamustine hydrochloride
2289
Bleomycin sulfate
252
Captopril
2522
Captopril
Leitungswasser
2463
Carboplatin
2242
2243
2245
3286
Carboplatin
409
3341
Carboplatin
[Cl-]
2253
Carfilzomib
3348
Carmustine
837
Carmustine
715
Carmustine
146
Carmustine
> 30°C
3314
Caspofungin acetate
1519
Caspofungin acetate
3308
Cefalotin sodium
999
Cefazolin sodium
301
Cefazolin sodium
3155
Cefazolin sodium
40°C
2868
Cefazolin sodium
25°C
2505
2707
Cefazolin sodium
pH
pH >7
2505
Cefepime dihydrochloride
2046
2141
Cefoperazone sodium
1103
Cefpirome sulfate
3677
Ceftazidime
3543
Ceftazidime
1651
1857
2141
Ceftazidime
2450
Ceftazidime
3289
Ceftazidime
25°C
2708
4264
Ceftazidime
pH
pH >10
1759
Ceftazidime
pH
pH > 9
3883
Ceftobiprole medocaril sodium
4650
Ceftriaxone disodium
3523
Ceftriaxone disodium
2238
3523
Ceftriaxone disodium
3523
Ceftriaxone disodium
100
Cefuroxime sodium
636
Cetuximab
> 25°C
2220
Chlormethine hydrochloride
558
Chlormethine hydrochloride
pH
558
Chlorpromazine hydrochloride
1960
Ciclosporin
1415
Ciclosporin
301
Ciprofloxacin lactate
948
Ciprofloxacin lactate
3475
Ciprofloxacin lactate
301
Ciprofloxacin lactate
14
285
288
Cisatracurium besylate
3601
Cisatracurium besylate
299
3466
3823
Cisatracurium besylate
pH
pH >7
3601
Cisplatin
410
Cisplatin
3578
Cisplatin
301
Cisplatin
3578
Cisplatin
1729
Cisplatin
pH
410
Cisplatin
[Cl-]
< 0,3%
409
Cladribine
3579
Clindamycin phosphate
pH
pH >7
3526
Clopidogrel bisulfate
> 25°C
4408
Co-trimoxazole
3583
Colistin mesilate sodium
2285
Conivaptan
3718
Cyclophosphamide
172
Cyclophosphamide
>70°C
170
Cytarabine
301
Dacarbazine
353
1383
Dacarbazine
3605
Daptomycin
2271
3439
Daptomycin
3439
Daunorubicin hydrochloride
1284
Daunorubicin hydrochloride
[< 0,5 mg / ml]
1265
Daunorubicin hydrochloride liposome
3577
Daunorubicin hydrochloride liposome
-20°C
3577
Daunorubicin hydrochloride liposome
pH
pH > 8
3577
Desoximetasone
Salicylsäure
2686
Desoximetasone
Harnstoff
2686
Dexamethasone acetate
OraPlus® / OraSweet® (1:1)
3124
Diamorphine hydrochloride
2051
Diamorphine hydrochloride
2051
2308
Dihydralazine mesilate
3613
Diltiazem hydrochloride
1851
Diltiazem hydrochloride
198
Dimenhydrinate
2087
Dithranol
Unguentum Merck®
3006
Dobutamine hydrochloride
3293
Dobutamine hydrochloride
1041
1058
3606
Dobutamine hydrochloride
pH
pH >7
3606
Dobutamine hydrochloride
pH
pH > 6
197
Dopamine hydrochloride
1965
Dopamine hydrochloride
1415
Dopamine hydrochloride
732
3638
Dopamine hydrochloride
pH
pH >7
3638
Dopamine hydrochloride
pH
pH > 6
197
Dornase alfa
Benzalkoniumchlorid
2770
Dornase alfa
Natrium-EDTA
2770
Doxapram hydrochloride
pH
pH >7
3612
Doxorubicin hydrochloride
847
1284
Doxorubicin hydrochloride
[< 0,5 mg / ml]
1265
Doxorubicin hydrochloride
1415
Doxorubicin hydrochloride
301
Doxorubicin hydrochloride
150
Doxorubicin hydrochloride
pH
pH >7
3645
Doxorubicin hydrochloride liposome peg
251
Doxycycline hyclate
1415
Droperidol
1415
Enalapril maleate
2561
Epinephrine hydrochloride
1965
2089
Epinephrine hydrochloride
3401
Epinephrine hydrochloride
3642
Epinephrine hydrochloride
2306
Epinephrine hydrochloride
pH
pH >7
3642
Epinephrine hydrochloride
pH
pH > 6
197
Epirubicin hydrochloride
[< 0,5 mg / ml]
1265
Epirubicin hydrochloride
pH
pH >7
3632
Eravacycline
-20°C
4709
Ertapenem
1906
1912
Ertapenem
3891
Ertapenem
-20°C
1906
Erythromycin lactobionate
pH
pH >10
20
Erythromycin lactobionate
pH
pH < 5,5
20
Esmolol hydrochloride
3607
Esomeprazole sodium
pH
2284
Fenoldopam mesylate
1803
Filgrastim
3618
Flucinonide
Harnstoff
2686
Flucloxacillin sodium
3522
Flucloxacillin sodium
3522
Flucloxacillin sodium
37°C
3189
Fludrocortisone
2621
Fluorouracil
1415
Fluorouracil
301
Folic acid
2816
Folinate calcium
150
Fosaprepitant dimeglumine
2295
Foscarnet sodium
3662
Fumagillin
2382
Fumagillin
2382
Furosemide
796
1855
Furosemide
301
Ganciclovir sodium
1415
Ganciclovir sodium
67
301
Gentamicin sulfate
3520
3643
Glycopyrronium bromide
pH
pH = 7
2834
Granisetron hydrochloride
57
Haloperidol lactate
230
Haloperidol lactate
230
Haloperidol lactate
230
Haloperidol lactate
1415
Haloperidol lactate
3466
3823
Heparin sodium
1415
Heparin sodium
1391
Hydralazine hydrochloride
2367
Hydralazine hydrochloride
2422
Hydralazine hydrochloride
Natrium-EDTA
3168
Hydralazine hydrochloride
Natriumbisulfit
3168
Hydrocortisone 17 valerate
Salicylsäure
2686
Hydrocortisone 17 valerate
Harnstoff
2686
Hydromorphone hydrochloride
1415
Hydroxocobalamin
3932
Hydroxyzine dihydrochloride
3600
Hydroxyzine dihydrochloride
pH
pH >7
3600
Ibuprofen lysinate
1985
Idarubicin hydrochloride
491
Imipenem - cilastatin sodium
898
1103
Imipenem - cilastatin sodium
21
150
Imipenem - cilastatin sodium
-20°C
21
Indocyanine green
4289
Insulin glulisine
3935
Irinotecan
1918
1920
1921
2143
2241
Iron dextran
312
Isavuconazonium sulfate
3829
Isoniazid
4113
Isoniazid
25°C
2818
Isoniazid
Saccharose
2932
Isoniazid
Lactose
2932
Isoniazid
Glucose
2932
Isoprenaline hydrochloride
1965
3660
Labetalol hydrochloride
1194
1380
3609
Lansoprazole
1625
Levofloxacine
3920
Levomepromazine
3279
Levosimendan
3417
Levosimendan
3417
Levothyroxine
3166
Lorazepam
1415
Melatonine
2872
Melatonine
2872
Melphalan
3584
Melphalan
160
Mercaptopurine
2396
Mercaptopurine
4°C
2396
Meropenem
3837
Meropenem
2120
3112
4122
Metamizol sodium
1685
Metamizol sodium
1685
Methadone hydrochloride
3489
Methotrexate sodium
1155
1158
3731
Methotrexate sodium
[ 1 mg/ ml]
145
Methotrexate sodium
301
Metoclopramide hydrochloride
301
Metolazone
2634
Metronidazole
3594
Midazolam hydrochloride
1887
Midazolam hydrochloride
1415
Midazolam hydrochloride
301
939
Midazolam hydrochloride
150
176
3466
3823
Minocycline hydrochloride
1415
Minocycline hydrochloride
301
Minocycline hydrochloride
263
Mitomycin
1178
Mitomycin
485
Mitomycin
-20°C [ 1 mg/ ml]
4526
Mitomycin
pH
485
Mitomycin
pH
pH < 5
835
Mitomycin
pH
pH >10
3575
4471
Mitomycin
pH
pH > 9
835
Mitomycin
pH
pH < 5.6
3575
4471
Mitoxantrone dihydrochloride
301
Morphine sulfate
119
Morphine sulfate
1415
Mycophenolate mofetil
1981
N-acetylcysteine
2426
Nadifloxacin
pH
3 < pH < 5
3284
Nalbuphine hydrochloride
1415
Nalbuphine hydrochloride
150
Necitumumab
3938
Nicardipine hydrochloride
3614
Nicardipine hydrochloride
44
3614
Nifedipine
2408
3206
Nifedipine
2446
Nitroprusside sodium
196
1151
1316
1379
3177
3381
Norepinephrine bitartrate
1965
Norepinephrine bitartrate
642
Norepinephrine bitartrate
pH
pH > 6
197
Octreotide acetate
4086
Ondansetron hydrochloride
1415
Ondansetron hydrochloride
150
1396
3574
Oritavancin
NaHCO3
3152
Oxacillin sodium
999
Oxacillin sodium
150
Oxaliplatin
3413
3634
Oxaliplatin
3634
Oxaliplatin
2259
Oxaliplatin
pH
pH >7
3634
Oxaliplatin
[Cl-]
2253
Oxytetracycline hydrochloride
3968
Pantoprazole sodium
2090
Penicillin G sodium
2056
Penicillin G sodium
3702
Pentobarbital sodium
3379
Pentostatin
pH
pH < 5
154
Pertuzumab
4686
Pethidine hydrochloride
Natriumbicarbonat
3525
Phenobarbital sodium
1415
Phenobarbital sodium
3379
Phenylephrine hydrochloride
pH
pH >7
3620
Phenytoin sodium
939
Phytomenadione
951
Piperacillin sodium
1103
Piperacillin sodium
3590
Piperacillin sodium / tazobactam
3586
Posaconazole
4380
Posaconazole
4380
Procainamide hydrochloride
705
1115
1461
Procainamide hydrochloride
370
Procainamide hydrochloride
370
Promethazine hydrochloride
301
Propofol
660
Propofol
660
Propofol
-20°C
3659
Quinupristine/dalfopristine
1513
Quinupristine/dalfopristine
-20°C
1513
Ramucirumab
3773
Rasburicase
1517
Remifentanil hydrochloride
3519
Remifentanil hydrochloride
4501
Remifentanil hydrochloride
pH
pH >7
4011
4501
Retinoic acid
3008
Rifampicin
3541
Rifampicin
3379
Rifampicin
3541
Rituximab
40°C
2881
3323
Rocuronium bromide
3564
Ropivacain hydrochloride
pH
pH > 6
1516
Sargramostim
335
Sodium bicarbonate
3466
Spironolactone
37°C
2559
Suxamethonium chloride
45
Suxamethonium chloride
45
Suxamethonium chloride
pH
pH >7
3631
Tacrolimus
pH
pH >7
3626
Tedizolid phosphate
3753
Teicoplanine
2450
Temocilline
2296
Temocilline
2275
Temozolomide
3117
Temsirolimus
3318
Temsirolimus
3318
Tenecteplase
3627
Terbutaline sulfate
449
Terbutaline sulfate
pH
pH >7
3597
Tetracycline hydrochloride
pH
9 < pH < 11
3284
Thalidomide
pH
pH > 6
3269
Thiopental sodium
3466
3823
Ticarcillin / clavulanic acid
3587
Ticarcillin / clavulanic acid
3587
Ticarcillin sodium
2020
Tigecycline
pH
pH >7
3332
Tramadol hydrochloride
2211
Trastuzumab
3077
Trastuzumab emtansine
2990
Tretinoin
2586
Triamcinolone
2786
Triamcinolone acetonide
Harnstoff
2686
Urapidil
4065
Vancomycin hydrochloride
2420
Vancomycin hydrochloride
37°C
1167
Verapamil hydrochloride
1100
Vinblastine sulfate
827
1009
Vincristine sulfate
150
Vindesine sulfate
150
Vinflunine
2838
Vinorelbine tartrate
2260
Vinorelbine tartrate
84
3641
Vinorelbine tartrate
pH
pH >7
3641
Voriconazole
3566
Voriconazole
3566
Zidovudine
3798
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