Last update :
18/04/2024
References   References 732  
Type : Journal

Research teams : Mount Prospect - Arnar-Stone laboratories
Authors : Gardella LA, Zaroslinski JF, Possley LH.
Title : Intropin (dopamine hydrochloride) intravenous admixture compatibility. Part 1: Stability with common intravenous fluids.
Reference : Am J Hosp Pharm ; 32: 575-578. 1975

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Thin Layer Chromatography
Ultraviolet spectrometry
Other methods : 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionDopamine hydrochloride Cardiotonic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,8 mg/ml 23-25°C Light
48 Hour
Stability in solutions Glass Glucose 5% 0,8 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Ringer’s lactate solution 0,8 mg/ml 23-25°C Light
48 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 0,8 mg/ml 25°C Light
24 Hour
Compatible 0.8 mg/ml + InjectionMannitol 20 mg/ml
Incompatible + NaHCO3
InjectionMannitol Various
Compatible 20 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml

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