Last update :
18/04/2024
References   References 642  
Type : Journal

Research teams : Gainesville - University of Florida, College of Pharmacy
Authors : Baumgartner TG, Knudsen AK, Dunn AJ, Kilroy RA.
Title : Norepinephrine stability in saline solutions.
Reference : Hosp Pharm ; 23: 44,49, 59. 1988

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Electrochemical detector
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection

List of drugs
InjectionAmobarbital sodium General anesthetic
Incompatible + InjectionNorepinephrine bitartrate
InjectionChlorothiazide sodium Diuretic
Incompatible + InjectionNorepinephrine bitartrate
InjectionNorepinephrine bitartrate Sympathomimetic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,004 & 0,008 mg/ml 25°C Light
24 Hour
Incompatible + InjectionAmobarbital sodium
Incompatible + InjectionChlorothiazide sodium
Incompatible + InjectionPentobarbital sodium
Incompatible + InjectionPhenobarbital sodium
Incompatible + InjectionPhenytoin sodium
Incompatible + InjectionSodium bicarbonate
Incompatible + InjectionStreptomycin sulfate
Incompatible 0.128 mg/ml + InjectionThiopental sodium 25 mg/ml
Incompatible + NaHCO3
InjectionPentobarbital sodium General anesthetic
Incompatible + InjectionNorepinephrine bitartrate
InjectionPhenobarbital sodium Antiepileptic
Incompatible + InjectionNorepinephrine bitartrate
InjectionPhenytoin sodium Antiepileptic
Incompatible + InjectionNorepinephrine bitartrate
InjectionSodium bicarbonate Electrolyte
Incompatible + InjectionNorepinephrine bitartrate
InjectionStreptomycin sulfate Antibiotic
Incompatible + InjectionNorepinephrine bitartrate
InjectionThiopental sodium General anesthetic
Incompatible 25 mg/ml + InjectionNorepinephrine bitartrate 0.128 mg/ml

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