Last update :
07/10/2024
References   References 2141  
Type : Journal

Research teams : Louvain - Drug Research Institute, University of Louvain
Authors : Barinian N, Chanteux H, Viaene E, Servais H, Tulkens PM.
Title : Stability and compatibility study of cefepime in comparaison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units.
Reference : J Antimicrob Chemother ; 51: 651-658. 2003

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 15 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 15 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionCefepime dihydrochloride Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Compatible 125 mg/ml + injectionAmikacin sulfate 15 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionDopamine hydrochloride 0.4 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionErythromycin lactobionate 5 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionFluconazole 2 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionFurosemide 10 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionGentamicin sulfate 6 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionInsulin 100 UI/ml + Water for Injection
Compatible 125 mg/ml + injectionIsosorbide dinitrate 0.2 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionKetamine hydrochloride 10 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionN-acetylcysteine 100 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionNicardipine hydrochloride 1 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPhenytoin sodium 50 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPiritramide 2 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPropofol 1 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionRemifentanil hydrochloride 200 µg/ml + Water for Injection
Compatible 125 mg/ml + injectionSufentanil citrate 0.005 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionTheophylline 20 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionTobramycin sulfate 6 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionUrapidil 5 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionValproic acid 100 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionVancomycin hydrochloride 30 mg/ml + Water for Injection
injectionCeftazidime Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Compatible 125 mg/ml + injectionAmikacin sulfate 15 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionDopamine hydrochloride 0.4 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionEpinephrine hydrochloride 50 µg/ml + Water for Injection
Incompatible 125 mg/ml + injectionErythromycin lactobionate 5 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionFluconazole 2 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionFurosemide 10 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionGentamicin sulfate 6 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionInsulin 100 UI/ml + Water for Injection
Compatible 125 mg/ml + injectionIsosorbide dinitrate 0.2 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionKetamine hydrochloride 10 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionN-acetylcysteine 100 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionNicardipine hydrochloride 1 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPhenytoin sodium 50 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPiritramide 2 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionPropofol 1 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionRemifentanil hydrochloride 200 µg/ml + Water for Injection
Compatible 125 mg/ml + injectionSufentanil citrate 0.005 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionTheophylline 20 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionTobramycin sulfate 6 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionUrapidil 5 mg/ml + Water for Injection
Compatible 125 mg/ml + injectionValproic acid 100 mg/ml + Water for Injection
Incompatible 125 mg/ml + injectionVancomycin hydrochloride 30 mg/ml + Water for Injection
injectionDobutamine hydrochloride Cardiotonic
Compatible 1 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionDopamine hydrochloride Cardiotonic
Compatible 0.4 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 0.4 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 50 µg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionErythromycin lactobionate Antibiotic
Incompatible 5 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 5 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 2 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 10 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionGentamicin sulfate Antibiotic
Compatible 6 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 6 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionInsulin Glucose-lowering
Compatible 100 UI/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 100 UI/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionIsosorbide dinitrate Vasodilator
Compatible 0.2 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 0.2 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionKetamine hydrochloride General anesthetic
Compatible 10 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 10 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionMidazolam hydrochloride Anxiolytic
Incompatible 5 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 5 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionN-acetylcysteine Antidote
Incompatible 100 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 100 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionNicardipine hydrochloride Vasodilator
Incompatible 1 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 1 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionPiritramide Analgesic
Incompatible 2 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 2 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionPropofol General anesthetic
Incompatible 1 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 1 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionRemifentanil hydrochloride Analgesic
Compatible 200 µg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 200 µg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionSufentanil citrate Analgesic
Compatible 0.005 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 0.005 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionTheophylline Various
Incompatible 20 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 20 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionTobramycin sulfate Antibiotic
Compatible 6 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 6 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionUrapidil Antihypertensive
Compatible 5 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 5 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionValproic acid Antiepileptic
Compatible 100 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Compatible 100 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection
injectionVancomycin hydrochloride Antibiotic
Compatible 30 mg/ml + injectionCefepime dihydrochloride 125 mg/ml + Water for Injection
Incompatible 30 mg/ml + injectionCeftazidime 125 mg/ml + Water for Injection

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