Last update :
16/07/2021
References   References 660  
Type : Journal
Web link : https://doi.org/10.1177/106002809603000303

Research teams : Columbus - The Ohio State University Hospitals, Department of Pharmacy
Authors : Michaels MR, Stauffer GL, Haas DP.
Title : Propofol compatibility with other intravenous drug products - Two new methods of evaluating IV emulsion compatibility.
Reference : Ann Pharmacotherapy ; 30: 228-232. 1996

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAlfentanil hydrochloride Analgesic
Incompatible 500 µg/ml + InjectionPropofol
InjectionAtracurium besylate Curarimimetic
Incompatible 10 mg/ml + InjectionPropofol
InjectionBretylium tosilate Anti-arrhythmic
Incompatible 50 mg/ml + InjectionPropofol
InjectionCalcium chloride Electrolyte
Incompatible 100 mg/ml + InjectionPropofol
InjectionCeftizoxime sodium Antibiotic
Incompatible 20 mg/ml + InjectionPropofol
InjectionCimetidine hydrochloride Antihistamine (H2)
Incompatible 150 mg/ml + InjectionPropofol
InjectionCisplatin Anticancer drug
Incompatible 0.3 mg/ml + InjectionPropofol
InjectionCyclophosphamide Anticancer drug
Incompatible 4 mg/ml + InjectionPropofol
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + InjectionPropofol
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionPropofol
InjectionDigoxin Cardiotonic
Incompatible 250 µg/ml + InjectionPropofol
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 1 mg/ml + InjectionPropofol
InjectionDopamine hydrochloride Cardiotonic
Incompatible 1.6 mg/ml + InjectionPropofol
InjectionDoxorubicin hydrochloride Anticancer drug
Incompatible 2 mg/ml + InjectionPropofol
InjectionEphedrine sulfate Sympathomimetic
Incompatible 5 mg/ml + InjectionPropofol
InjectionEpinephrine hydrochloride Sympathomimetic
Incompatible 0.1 µg/ml + InjectionPropofol
InjectionFamotidine Antihistamine (H2)
Incompatible 0.04 mg/ml + InjectionPropofol
InjectionFluconazole Antifungal
Incompatible 2 mg/ml + InjectionPropofol
InjectionGentamicin sulfate Antibiotic
Incompatible 2 mg/ml + InjectionPropofol
InjectionGlycopyrronium bromide Antimuscarinic
Incompatible 0.2 mg/ml + InjectionPropofol
InjectionHeparin sodium Anticoagulant
Incompatible 1000 UI/ml + InjectionPropofol
InjectionHydralazine hydrochloride Antihypertensive
Incompatible 20 mg/ml + InjectionPropofol
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + InjectionPropofol
InjectionKetamine hydrochloride General anesthetic
Incompatible 10 mg/ml + InjectionPropofol
InjectionLidocaine hydrochloride Local anesthetic
Incompatible 10 mg/ml + InjectionPropofol
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 63 mg/ml + InjectionPropofol
InjectionMetoclopramide hydrochloride Antiemetic
Incompatible 5 mg/ml + InjectionPropofol
InjectionMidazolam hydrochloride Anxiolytic
Incompatible 1 mg/ml + InjectionPropofol
InjectionMorphine sulfate Analgesic
Incompatible 10 mg/ml + InjectionPropofol
InjectionNaloxone hydrochloride Antidote
Incompatible 0.4 mg/ml + InjectionPropofol
InjectionPancuronium bromide Curarimimetic
Incompatible 1 mg/ml + InjectionPropofol
InjectionPentobarbital sodium General anesthetic
Incompatible 50 mg/ml + InjectionPropofol
InjectionPhenobarbital sodium Antiepileptic
Incompatible 65 mg/ml + InjectionPropofol
InjectionPhenylephrine hydrochloride Sympathomimetic
Incompatible 0.1 mg/ml + InjectionPropofol
InjectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + InjectionPropofol
InjectionPotassium chloride Electrolyte
Incompatible 200 mEq/l + InjectionPropofol
InjectionPropofol General anesthetic
Factors which affect stability Solvent Glucose 5% Induces Degradation
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible + NaHCO3
Incompatible + Glucose 5%
Incompatible + InjectionAlfentanil hydrochloride 500 µg/ml
Incompatible + InjectionAtracurium besylate 10 mg/ml
Incompatible + InjectionBretylium tosilate 50 mg/ml
Incompatible + InjectionCalcium chloride 100 mg/ml
Incompatible + InjectionCeftizoxime sodium 20 mg/ml
Incompatible + InjectionCimetidine hydrochloride 150 mg/ml
Incompatible + InjectionCisplatin 0.3 mg/ml
Incompatible + InjectionCyclophosphamide 4 mg/ml
Incompatible + InjectionDexamethasone sodium phosphate 4 mg/ml
Incompatible + InjectionDiazepam 5 mg/ml
Incompatible + InjectionDigoxin 250 µg/ml
Incompatible + InjectionDobutamine hydrochloride 1 mg/ml
Incompatible + InjectionDopamine hydrochloride 1.6 mg/ml
Incompatible + InjectionDoxorubicin hydrochloride 2 mg/ml
Incompatible + InjectionEphedrine sulfate 5 mg/ml
Incompatible + InjectionEpinephrine hydrochloride 0.1 µg/ml
Incompatible + InjectionFamotidine 0.04 mg/ml
Incompatible + InjectionFluconazole 2 mg/ml
Incompatible + InjectionGentamicin sulfate 2 mg/ml
Incompatible + InjectionGlycopyrronium bromide 0.2 mg/ml
Incompatible + InjectionHeparin sodium 1000 UI/ml
Incompatible + InjectionHydralazine hydrochloride 20 mg/ml
Incompatible + InjectionImipenem - cilastatin sodium 5 mg/ml
Incompatible + InjectionKetamine hydrochloride 10 mg/ml
Incompatible + InjectionLidocaine hydrochloride 10 mg/ml
Incompatible + InjectionMethylprednisolone sodium succinate 63 mg/ml
Incompatible + InjectionMetoclopramide hydrochloride 5 mg/ml
Incompatible + InjectionMidazolam hydrochloride 1 mg/ml
Incompatible + InjectionMorphine sulfate 10 mg/ml
Incompatible + InjectionNaloxone hydrochloride 0.4 mg/ml
Incompatible + InjectionPancuronium bromide 1 mg/ml
Incompatible + InjectionPentobarbital sodium 50 mg/ml
Incompatible + InjectionPhenobarbital sodium 65 mg/ml
Incompatible + InjectionPhenylephrine hydrochloride 0.1 mg/ml
Incompatible + InjectionPhenytoin sodium 50 mg/ml
Incompatible + InjectionPotassium chloride 200 mEq/l
Incompatible + InjectionPropranolol hydrochloride 1 mg/ml
Incompatible + InjectionRanitidine hydrochloride 25 mg/ml
Incompatible + InjectionScopolamine hydrobromide 0.4 mg/ml
Incompatible + InjectionSodium bicarbonate 84 mg/ml
Incompatible + InjectionTicarcillin / clavulanic acid 31 mg/ml
Incompatible + InjectionTobramycin sulfate 2 mg/ml
Incompatible + InjectionVancomycin hydrochloride 4 mg/ml
Incompatible + InjectionVecuronium bromide 1 mg/ml
Incompatible + InjectionVerapamil hydrochloride 2.5 mg/ml
InjectionPropranolol hydrochloride Beta-blocker
Incompatible 1 mg/ml + InjectionPropofol
InjectionRanitidine hydrochloride Antihistamine (H2)
Incompatible 25 mg/ml + InjectionPropofol
InjectionScopolamine hydrobromide Antimuscarinic
Incompatible 0.4 mg/ml + InjectionPropofol
InjectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + InjectionPropofol
InjectionTicarcillin / clavulanic acid Antibiotic
Incompatible 31 mg/ml + InjectionPropofol
InjectionTobramycin sulfate Antibiotic
Incompatible 2 mg/ml + InjectionPropofol
InjectionVancomycin hydrochloride Antibiotic
Incompatible 4 mg/ml + InjectionPropofol
InjectionVecuronium bromide Curarimimetic
Incompatible 1 mg/ml + InjectionPropofol
InjectionVerapamil hydrochloride Anti-arrhythmic
Incompatible 2.5 mg/ml + InjectionPropofol

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