Last update :
18/04/2024
References   References 197  
Type : Journal

Research teams : Derby - Institute of Health and Community studies, Derbyshire college of higher education
Authors : Allwood MC.
Title : The stability of four catecholamines in 5% glucose infusions.
Reference : J Clin Pharm Ther ; 16: 337-340. 1991

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
Stability indicating capability inadequately assessed

List of drugs
InjectionDobutamine hydrochloride Cardiotonic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Factors which affect stability PH PH > 6 Induces Degradation
Stability in solutions Polyvinyl chloride Glucose 5% 1 & 5 mg/ml 5°C Protect from light
30 Day
InjectionDopamine hydrochloride Cardiotonic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Factors which affect stability PH PH > 6 Induces Degradation
Stability in solutions Polyvinyl chloride Glucose 5% 3,2 mg/ml 5°C Protect from light
14 Day
InjectionEpinephrine hydrochloride Sympathomimetic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Factors which affect stability PH PH > 6 Induces Degradation
Stability in solutions Polyvinyl chloride Glucose 5% 16 µg/ml 5°C Protect from light
20 Day
InjectionNorepinephrine bitartrate Sympathomimetic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Factors which affect stability PH PH > 6 Induces Degradation
Stability in solutions Polyvinyl chloride Glucose 5% 0,016 & 0,04 mg/ml 5°C Protect from light
30 Day

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