Last update :
28/02/2024
References   References 2450  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/22/2731

Research teams : Charleston - Medical University of South Carolina
Authors : Manduru M, Fariello A, White RL, Fox JL, Bosso JA.
Title : Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution
Reference : Am J Health-Syst Pharm ; 53: 2731 - 2734. 1996

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products

List of drugs
InjectionCeftazidime Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,1 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,1 mg/ml 37°C Light
2 Hour
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,1 mg/ml 4°C Protect from light
4 Day
Incompatible 0,1 mg/ml + InjectionTeicoplanine 0,025 mg/ml + Dianéal® PD2 1.5% glucose (Baxter)
InjectionTeicoplanine Antibiotic
Factors which affect stability Temperature Induces Degradation
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,025 mg/ml 25°C Light
32 Hour
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,025 mg/ml 37°C Light
8 Hour
Stability in solutions Polyvinyl chloride Dianéal® PD2 1.5% glucose (Baxter) 0,025 mg/ml 4°C Protect from light
4 Day
Incompatible 0,025 mg/ml + InjectionCeftazidime 0,1 mg/ml + Dianéal® PD2 1.5% glucose (Baxter)

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