Last update :
01/10/2024
References   References 301  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/11/1295

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Title : Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 1295-1300. 1997

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 7 mg/ml + Parenteral nutrition (binary mixture)
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionAminophylline Various
Compatible 2.5 mg/ml + Parenteral nutrition (binary mixture)
injectionAmphotericin B Antifungal
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.6 mg/ml + Parenteral nutrition (binary mixture)
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + Parenteral nutrition (binary mixture)
injectionAztreonam Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
injectionBumetanide Diuretic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
injectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionCefazolin sodium Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCeftazidime Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + Parenteral nutrition (binary mixture)
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionCiclosporin Immunosuppressant
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + Parenteral nutrition (binary mixture)
injectionCiprofloxacin lactate Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionCisplatin Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + Parenteral nutrition (binary mixture)
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionCytarabine Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionDigoxin Cardiotonic
Compatible 250 µg/ml + Parenteral nutrition (binary mixture)
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 & 50 mg/ml + Parenteral nutrition (binary mixture)
injectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + Parenteral nutrition (binary mixture)
injectionDoxorubicin hydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + Parenteral nutrition (binary mixture)
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionFentanyl citrate Analgesic
Compatible 12.5 & 50 µg/ml + Parenteral nutrition (binary mixture)
injectionFluconazole Antifungal
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionFluorouracil Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 16 mg/ml + Parenteral nutrition (binary mixture)
injectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionFurosemide Diuretic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 3 mg/ml + Parenteral nutrition (binary mixture)
injectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
injectionGanciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + Parenteral nutrition (binary mixture)
injectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + Parenteral nutrition (binary mixture)
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + Parenteral nutrition (binary mixture)
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + Parenteral nutrition (binary mixture)
injectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + Parenteral nutrition (binary mixture)
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + Parenteral nutrition (binary mixture)
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + Parenteral nutrition (binary mixture)
injectionMannitol Various
Compatible 150 mg/ml + Parenteral nutrition (binary mixture)
injectionMesna Cytoprotective
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionMethotrexate sodium Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 15 mg/ml + Parenteral nutrition (binary mixture)
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionMetoclopramide hydrochloride Antiemetic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionMinocycline hydrochloride Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (binary mixture)
injectionMitoxantrone dihydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
injectionMorphine sulfate Analgesic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
injectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.016 mg/ml + Parenteral nutrition (binary mixture)
injectionOctreotide acetate Various
Compatible 0.010 mg/ml + Parenteral nutrition (binary mixture)
injectionOfloxacin Antibiotic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
injectionOndansetron hydrochloride Antiemetic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + Parenteral nutrition (binary mixture)
injectionPentobarbital sodium General anesthetic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
injectionPhenobarbital sodium Antiepileptic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + Parenteral nutrition (binary mixture)
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + Parenteral nutrition (binary mixture)
injectionPotassium phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (binary mixture)
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
injectionPromethazine hydrochloride Antihistamine (H1)
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + Parenteral nutrition (binary mixture)
injectionSodium Phosphate Electrolyte
Incompatible 1 mmol/ml + Parenteral nutrition (binary mixture)
injectionTacrolimus Immunosuppressant
Compatible 1000 µg/ml + Parenteral nutrition (binary mixture)
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + Parenteral nutrition (binary mixture)
injectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionZidovudine Antiviral
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)

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