Last update :
17/09/2021
References   References 21  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/43/11/2803

Research teams : West Point - Merck and Co
Authors : Bigley FP, Forsyth RJ, Henley MW.
Title : Compatibility of imipenem-cilastatin sodium with commonly used intravenous solutions.
Reference : Am J Hosp Pharm ; 43: 2803-2809. 1986

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionImipenem - cilastatin sodium Antibiotic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Factors which affect stability Temperature -20°C Induces Degradation
Factors which affect stability Concentration Reduction Induces Enhanced stability
Stability in solutions Glass Water for Injection 2.5 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Glass Water for Injection 2.5 & 5 mg/ml 25°C Not specified
9 Hour
Stability in solutions Glass Water for Injection 5 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 2.5 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Glass Sodium chloride 0,9% 2.5 & 5 mg/ml 25°C Not specified
9 Hour
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Glass Glucose 5% 2.5 mg/ml 25°C Not specified
6 Hour
Stability in solutions Glass Glucose 5% 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Glass Glucose 5% 5 mg/ml 25°C Not specified
3 Hour
Stability in solutions Glass Ringer’s lactate solution 2.5 mg/ml 25°C Not specified
6 Hour
Stability in solutions Glass Ringer’s lactate solution 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Glass Ringer’s lactate solution 5 mg/ml 25°C Not specified
3 Hour
Stability in solutions Glass Glucose 10% 2.5 & 5 mg/ml 25°C Not specified
3 Hour
Stability in solutions Glass Glucose 10% 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
Incompatible 250 & 500 mg/ml + InjectionSodium bicarbonate 50 mg/ml
Incompatible + NaHCO3
InjectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + InjectionImipenem - cilastatin sodium 250 & 500 mg/ml

  Mentions Légales