Last update :
18/04/2024
References   References 196  
Type : Journal

Research teams : New Orleans - College of Pharmacy, Xavier University of Louisiana
Authors : Pramar Y, Das Gupta V, Neal Gardner S, Yau B.
Title : Stabilities of dobutamine, dopamine, nitroglycerin and sodium nitroprusside in disposable plastic syringes.
Reference : J Clin Pharm Ther ; 16: 203-207. 1991

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionDobutamine hydrochloride Cardiotonic
Stability in solutions Polypropylen Syringe Glucose 5% 5 mg/ml 25°C Light
24 Hour
InjectionDopamine hydrochloride Cardiotonic
Stability in solutions Polypropylen Syringe Glucose 5% 4 mg/ml 25°C Light
24 Hour
InjectionNitroglycerin Vasodilator
Stability in solutions Polypropylen Syringe Glucose 5% 1 mg/ml 25°C Light
24 Hour
InjectionNitroprusside sodium Vasodilator
Factors which affect stability Storage Light Induces Degradation
Stability in solutions Polypropylen Syringe Glucose 5% 1 mg/ml 25°C Protect from light
24 Hour

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