Last update :
27/09/2020
References   References 2872  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2910

Research teams : Queensland - Grif!th University, School of Pharmacy
Authors : Haywood A, Burrell A, van Breda K, Testa C, Norris R.
Title : Stability of Melatonin in an Extemporaneously Compounded Sublingual Solution and Hard Gelatin Capsule
Reference : Int J Pharm Compound ; 13, 2: 170-174. 2009

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
Oral solutionMelatonine Hormone
Factors which affect stability Storage Light Induces Degradation
Stability in solutions Glass Powder 1000 mg
Stevia powder 250 mg
Ethanol 15 ml
Fruit aroma 2 ml
Glycerin >> 100 ml
24-26°C Protect from light
90 Day
Stability in solutions Glass Powder 1000 mg
Stevia powder 250 mg
Ethanol 15 ml
Fruit aroma 2 ml
Glycerin >> 100 ml
3-5°C Protect from light
90 Day
CapsuleMelatonine Hormone
Factors which affect stability Storage Light Induces Degradation
Stability in solutions Glass Powder 3 mg
Food coloring 100 mg
Methocel E4M® 100 mg
Lactose 220 mg
24-26°C Protect from light
90 Day
Stability in solutions Glass Powder 3 mg
Food coloring 100 mg
Methocel E4M® 100 mg
Lactose 220 mg
39-41°C Protect from light
90 Day

  Mentions Légales