Last update :
27/11/2024
References   References 491  
Type : Journal

Research teams : Columbus - The Ohio State University Hospitals, Department of Pharmacy
Authors : Turowski RC, Durthaler JM.
Title : Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 48: 2181-2184. 1991

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Incompatible 30 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Incompatible 20 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Incompatible 20 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 6 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionClindamycin phosphate Antibiotic
Incompatible 12 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCyclophosphamide Anticancer drug
Compatible 4 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCytarabine Anticancer drug
Compatible 6 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 0.2 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 1 & 50 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionDroperidol Neuroleptic
Compatible 0.04 & 2.5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionErythromycin lactobionate Antibiotic
Compatible 2 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionEtoposide Anticancer drug
Incompatible 0.4 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 0,8 & 10 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Incompatible 3 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Incompatible 100 & 1000 UI/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 2 & 50 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionIdarubicin hydrochloride Anticancer drug
Factors which affect stability Solvent NaHCO3 Induces Degradation
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
Incompatible 1 mg/ml + injectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionLorazepam 2 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMagnesium sulfate 2 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMannitol 12.5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionMethotrexate sodium 25 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionPethidine hydrochloride 1 & 50 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionPotassium chloride 30 mEq/l + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionSodium bicarbonate 7.56 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionVancomycin hydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionVincristine sulfate 1 mg/ml + Sodium chloride 0,9%
Incompatible + NaHCO3
Incompatible 1 mg/ml + injectionAciclovir sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionAmpicillin sodium - sulbactam sodium 30 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionCeftazidime 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCimetidine hydrochloride 6 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionClindamycin phosphate 12 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCyclophosphamide 4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCytarabine 6 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionDexamethasone sodium phosphate 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionDexamethasone sodium phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionDiphenhydramine hydrochloride 1 & 50 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionDroperidol 0.04 & 2.5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionErythromycin lactobionate 2 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionEtoposide 0.4 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionFurosemide 0,8 & 10 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionGentamicin sulfate 3 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionHeparin sodium 100 & 1000 UI/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionHydrocortisone sodium succinate 2 & 50 mg/ml + Sodium chloride 0,9%
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionLorazepam Anxiolytic
Incompatible 2 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMagnesium sulfate Electrolyte
Compatible 2 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMannitol Various
Compatible 12.5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMethotrexate sodium Anticancer drug
Incompatible 25 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Incompatible 1 & 50 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 30 mEq/l + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionSodium bicarbonate Electrolyte
Incompatible 7.56 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Incompatible 4 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionVincristine sulfate Anticancer drug
Incompatible 1 mg/ml + injectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%

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