Last update :
21/09/2021
References   References 491  
Type : Journal

Research teams : Columbus - The Ohio State University Hospitals, Department of Pharmacy
Authors : Turowski RC, Durthaler JM.
Title : Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 48: 2181-2184. 1991

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Incompatible 30 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Incompatible 20 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Incompatible 20 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 6 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionClindamycin phosphate Antibiotic
Incompatible 12 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCyclophosphamide Anticancer drug
Compatible 4 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCytarabine Anticancer drug
Compatible 6 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 0.2 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 1 & 50 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionDroperidol Neuroleptic
Compatible 0.04 & 2.5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionErythromycin lactobionate Antibiotic
Compatible 2 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionEtoposide Anticancer drug
Incompatible 0.4 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Incompatible 0,8 & 10 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionGentamicin sulfate Antibiotic
Incompatible 3 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Incompatible 100 & 1000 UI/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 2 & 50 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionIdarubicin hydrochloride Anticancer drug
Factors which affect stability Solvent NaHCO3 Induces Degradation
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
Incompatible 1 mg/ml + InjectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionLorazepam 2 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionMagnesium sulfate 2 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionMannitol 12.5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionMethotrexate sodium 25 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionPethidine hydrochloride 1 & 50 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionPotassium chloride 30 mEq/l + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionSodium bicarbonate 7.56 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionVancomycin hydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionVincristine sulfate 1 mg/ml + Sodium chloride 0,9%
Incompatible + NaHCO3
Incompatible 1 mg/ml + InjectionAciclovir sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 30 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionCeftazidime 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCimetidine hydrochloride 6 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionClindamycin phosphate 12 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCyclophosphamide 4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCytarabine 6 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionDexamethasone sodium phosphate 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionDexamethasone sodium phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionDiphenhydramine hydrochloride 1 & 50 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionDroperidol 0.04 & 2.5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionErythromycin lactobionate 2 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionEtoposide 0.4 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionFurosemide 0,8 & 10 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionGentamicin sulfate 3 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionHeparin sodium 100 & 1000 UI/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionHydrocortisone sodium succinate 2 & 50 mg/ml + Sodium chloride 0,9%
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionLorazepam Anxiolytic
Incompatible 2 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionMagnesium sulfate Electrolyte
Compatible 2 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionMannitol Various
Compatible 12.5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionMethotrexate sodium Anticancer drug
Incompatible 25 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionPethidine hydrochloride Analgesic
Incompatible 1 & 50 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 30 mEq/l + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionSodium bicarbonate Electrolyte
Incompatible 7.56 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 4 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionVincristine sulfate Anticancer drug
Incompatible 1 mg/ml + InjectionIdarubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%

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