Last update :
27/09/2020
References   References 4113  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Lee J, Moriyama B, Henning S, Danner R, Walsh T, Penzak S, Grimes G, Gopal K.
Title : Stability of isoniazid injection in i.v. solutions.
Reference : Am J Health-Syst Pharm ; 75, 10: 622-626. 2018

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
InjectionIsoniazid Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Reduced stability
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polyolefine Sodium chloride 0,9% 0,5 mg/ml 2-8°C Protect from light
72 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 0,5 mg/ml 20-25°C Protect from light
72 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 6 mg/ml 2-8°C Protect from light
72 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 6 mg/ml 20-25°C Protect from light
72 Hour
Stability in solutions Polyolefine Glucose 5% 6 mg/ml 2-8°C Protect from light
24 Hour

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