Last update :
28/01/2023
References   References 1415  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Title : Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
Reference : JPEN ; 23: 67-74. 1999

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 7 mg/ml + Parenteral nutrition (with lipids)
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionAminophylline Various
Compatible 2.5 mg/ml + Parenteral nutrition (with lipids)
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + Parenteral nutrition (with lipids)
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + Parenteral nutrition (with lipids)
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
InjectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCeftazidime Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + Parenteral nutrition (with lipids)
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionCiclosporin Immunosuppressant
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + Parenteral nutrition (with lipids)
InjectionCiprofloxacin lactate Antibiotic
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionCisplatin Anticancer drug
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + Parenteral nutrition (with lipids)
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionCytarabine Anticancer drug
Compatible 50 mg/ml + Parenteral nutrition (with lipids)
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionDigoxin Cardiotonic
Compatible 250 µg/ml + Parenteral nutrition (with lipids)
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 & 50 mg/ml + Parenteral nutrition (with lipids)
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
InjectionDopamine hydrochloride Cardiotonic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 3.2 mg/ml + Parenteral nutrition (with lipids)
InjectionDoxorubicin hydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionDoxycycline hyclate Antibiotic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionDroperidol Neuroleptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.4 mg/ml + Parenteral nutrition (with lipids)
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + Parenteral nutrition (with lipids)
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionFentanyl citrate Analgesic
Compatible 12.5 & 50 µg/ml + Parenteral nutrition (with lipids)
InjectionFluconazole Antifungal
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionFluorouracil Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 16 mg/ml + Parenteral nutrition (with lipids)
InjectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionFurosemide Diuretic
Compatible 3 mg/ml + Parenteral nutrition (with lipids)
InjectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
InjectionGanciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + Parenteral nutrition (with lipids)
InjectionHaloperidol lactate Neuroleptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (with lipids)
InjectionHeparin sodium Anticoagulant
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 100 UI/ml + Parenteral nutrition (with lipids)
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionHydromorphone hydrochloride Analgesic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.5 mg/ml + Parenteral nutrition (with lipids)
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionIfosfamide Anticancer drug
Compatible 25 mg/ml + Parenteral nutrition (with lipids)
InjectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + Parenteral nutrition (with lipids)
InjectionLorazepam Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.1 mg/ml + Parenteral nutrition (with lipids)
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + Parenteral nutrition (with lipids)
InjectionMannitol Various
Compatible 150 mg/ml + Parenteral nutrition (with lipids)
InjectionMeropenem Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionMesna Cytoprotective
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + Parenteral nutrition (with lipids)
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionMinocycline hydrochloride Antibiotic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (with lipids)
InjectionMitoxantrone dihydrochloride Anticancer drug
Compatible 0.5 mg/ml + Parenteral nutrition (with lipids)
InjectionMorphine sulfate Analgesic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 15 mg/ml + Parenteral nutrition (with lipids)
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
InjectionNalbuphine hydrochloride Antidote
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
InjectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
InjectionOctreotide acetate Various
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionOfloxacin Antibiotic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
InjectionOndansetron hydrochloride Antiemetic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
InjectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + Parenteral nutrition (with lipids)
InjectionPentobarbital sodium General anesthetic
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
InjectionPhenobarbital sodium Antiepileptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + Parenteral nutrition (with lipids)
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + Parenteral nutrition (with lipids)
InjectionPotassium phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (with lipids)
InjectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + Parenteral nutrition (with lipids)
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + Parenteral nutrition (with lipids)
InjectionSodium Phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (with lipids)
InjectionTacrolimus Immunosuppressant
Compatible 1000 µg/ml + Parenteral nutrition (with lipids)
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + Parenteral nutrition (with lipids)
InjectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
InjectionZidovudine Antiviral
Compatible 4 mg/ml + Parenteral nutrition (with lipids)

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