Last update :
16/07/2021
Antibiotic   Imipenem - cilastatin sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Arzomeba Chile
Bacqure Ecuador, Morocco, Peru
Betatrexil Ecuador
Cilanem Chile
Cilapem Turkey
Conet Slovenia
Gimipen Colombia
Imacina Chile
Imipen Italy
Imistatin Argentina
Linataz Colombia
Perloyem Argentina
Primaxin Australia, Canada, Great Britain, Greece, New Zealand, Peru, United States of America
Silanem Turkey
Silpen Chile
Tenacid Italy
Tesilan Colombia
Tienam Belgium, Chile, Colombia, Croatia, Denmark, Ecuador, Egypt, Finland, France, Germany, Hungary, Iran, Ireland, Italy, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, Norway, Peru, Poland, Portugal, Republic of South Africa, Romania, Saudi Arabia, Spain, Sweden, Switzerland, Thailand, Tunisia, Turkey, United Arab Emirates
Zienam Argentina, Austria, Germany, Venezuela
Stability in solutions   Injection   Stability in solutions : Imipenem - cilastatin sodium     
Container Solvent Concentration Temperature Storage Length of time References
Glass Water for Injection 2.5 mg/ml 4°C Protect from light
72 Hour
21
Level of evidence B

Glass Water for Injection 2.5 & 5 mg/ml 25°C Not specified
9 Hour
21
Level of evidence B

Glass Water for Injection 5 mg/ml 4°C Protect from light
48 Hour
21
Level of evidence B

Glass Sodium chloride 0,9% 2.5 mg/ml 4°C Protect from light
72 Hour
21
Level of evidence B

Glass Sodium chloride 0,9% 2.5 & 5 mg/ml 25°C Not specified
9 Hour
21
Level of evidence B

Glass Sodium chloride 0,9% 5 mg/ml 4°C Protect from light
48 Hour
21
Level of evidence B

Glass Glucose 5% 2.5 mg/ml 25°C Not specified
6 Hour
21
Level of evidence B

Glass Glucose 5% 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
21
Level of evidence B

Glass Glucose 5% 5 mg/ml 25°C Not specified
3 Hour
21
Level of evidence B

Glass Ringer’s lactate solution 2.5 mg/ml 25°C Not specified
6 Hour
21
Level of evidence B

Glass Ringer’s lactate solution 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
21
Level of evidence B

Glass Ringer’s lactate solution 5 mg/ml 25°C Not specified
3 Hour
21
Level of evidence B

Glass Glucose 10% 2.5 & 5 mg/ml 25°C Not specified
3 Hour
21
Level of evidence B

Glass Glucose 10% 2.5 & 5 mg/ml 4°C Protect from light
24 Hour
21
Level of evidence B

Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 22°C Protect from light
24 Hour
1067
Level of evidence C

Polyethylene NaCl 0,9% or Glucose 5% 2,5 mg/ml 4°C Protect from light
24 Hour
1067
Level of evidence C

Elastomer Water for Injection 8 mg/ml 25°C
3 Hour
2042
Level of evidence D

Elastomer Water for Injection 8 mg/ml 37°C
2 Hour
2042
Level of evidence D

Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 25°C Not specified
4 Hour
133
Level of evidence D

Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 5°C Protect from light
24 Hour
133
Level of evidence D

Elastomer Glucose 5% 5 mg/ml 25°C Not specified
24 Hour
604
Manufacturer's stability data

Elastomer Glucose 5% 5 mg/ml 4°C Protect from light
3 Day
604
Manufacturer's stability data

Ethylene vinyl acetate Sodium chloride 0,9% 2,5 & 5 mg/ml 4°C Protect from light
3 Day
1811
Level of evidence B+

Not specified NaCl 0,9% or Glucose 5% 5 mg/ml 2-8°C Not specified
8 Hour
4298
Level of evidence C

Not specified NaCl 0,9% or Glucose 5% 5 mg/ml 23-27°C Not specified
4 Hour
4298
Level of evidence C


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