Last update :
21/09/2021
References   References 335  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Bready BB, Kwan JW, Santiago NM.
Title : Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 49: 402-406. 1992

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 7 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 0.6 mg/ml + InjectionSargramostim 10 µg/ml + Glucose 5%
InjectionAmpicillin sodium Antibiotic
Incompatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Incompatible 20/10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionAmsacrine Anticancer drug
Incompatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Glucose 5%
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionBleomycin sulfate Anticancer drug
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCarmustine Anticancer drug
Compatible 1.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCefonicid sodium Antibiotic
Incompatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCefoperazone sodium Antibiotic
Incompatible 40 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCeforanide Antibiotic
Compatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Incompatible 40 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionChlormethine hydrochloride Anticancer drug
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionChlorpromazine hydrochloride Anxiolytic
Incompatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCisplatin Anticancer drug
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionCytarabine Anticancer drug
Compatible 50 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDacarbazine Anticancer drug
Compatible 4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDactinomycin Anticancer drug
Compatible 10 µg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionFloxuridine Anticancer drug
Compatible 3 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionFluorouracil Anticancer drug
Compatible 16 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Compatible 3 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionGanciclovir sodium Antiviral
Incompatible 20 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionHaloperidol lactate Neuroleptic
Incompatible 0.2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionHydromorphone hydrochloride Analgesic
Incompatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionIdarubicin hydrochloride Anticancer drug
Incompatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionIfosfamide Anticancer drug
Compatible 25 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionLorazepam Anxiolytic
Incompatible 0.1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 0.1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMannitol Various
Compatible 150 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMesna Cytoprotective
Compatible 10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMinocycline hydrochloride Antibiotic
Compatible 0.2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMitomycin Anticancer drug
Incompatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMitoxantrone dihydrochloride Anticancer drug
Compatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionMorphine sulfate Analgesic
Incompatible 1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionOndansetron hydrochloride Antiemetic
Incompatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionPentostatin Anticancer drug
Compatible 0.4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionPiperacillin sodium Antibiotic
Incompatible 40 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionSargramostim Various
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible 10 µg/ml + NaHCO3
Compatible 10 µg/ml + Parenteral nutrition (binary mixture)
Incompatible 10 µg/ml + InjectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionAmphotericin B 0.6 mg/ml + Glucose 5%
Incompatible 10 µg/ml + InjectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionAmsacrine 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionAmsacrine 1 mg/ml + Glucose 5%
Compatible 10 µg/ml + InjectionAztreonam 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionBleomycin sulfate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionButorphanol tartrate 0.04 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCalcium gluconate 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCarboplatin 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCarmustine 1.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionCefonicid sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionCefoperazone sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCeforanide 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCefuroxime sodium 30 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionChlormethine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionChlorpromazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCimetidine hydrochloride 12 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCisplatin 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionClindamycin phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCyclophosphamide 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionCytarabine 50 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDacarbazine 4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDactinomycin 10 µg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDiphenhydramine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDoxorubicin hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDoxycycline hyclate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionDroperidol 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionEtoposide 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionFloxuridine 3 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionFluorouracil 16 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionGanciclovir sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionHeparin sodium 100 UI/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionHydroxyzine dihydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionIdarubicin hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionIfosfamide 25 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMannitol 150 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMesna 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMethotrexate sodium 15 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMinocycline hydrochloride 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionMitomycin 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionMitoxantrone dihydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionNetilmicin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionOndansetron hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionPentostatin 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionPethidine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionPiperacillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionPotassium chloride 100 mEq/l + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionProchlorperazine edysilate 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionPromethazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionRanitidine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionTeniposide 0.1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionTicarcillin / clavulanic acid 31 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + InjectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionVancomycin hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionVinblastine sulfate 0.12 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionVincristine sulfate 0.05 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + InjectionZidovudine 4 mg/ml + Sodium chloride 0,9%
InjectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionTeniposide Anticancer drug
Compatible 0.1 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%
InjectionZidovudine Antiviral
Compatible 4 mg/ml + InjectionSargramostim 10 µg/ml + Sodium chloride 0,9%

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