Last update :
06/12/2024
References   References 335  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Bready BB, Kwan JW, Santiago NM.
Title : Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 49: 402-406. 1992

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 7 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 0.6 mg/ml + injectionSargramostim 10 µg/ml + Glucose 5%
injectionAmpicillin sodium Antibiotic
Incompatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Incompatible 20/10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionAmsacrine Anticancer drug
Incompatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Glucose 5%
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionBleomycin sulfate Anticancer drug
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCarmustine Anticancer drug
Compatible 1.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCefonicid sodium Antibiotic
Incompatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCefoperazone sodium Antibiotic
Incompatible 40 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCeforanide Antibiotic
Compatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Incompatible 40 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionChlormethine hydrochloride Anticancer drug
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionChlorpromazine hydrochloride Anxiolytic
Incompatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCisplatin Anticancer drug
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDacarbazine Anticancer drug
Compatible 4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDactinomycin Anticancer drug
Compatible 10 µg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionFloxuridine Anticancer drug
Compatible 3 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Compatible 3 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionGanciclovir sodium Antiviral
Incompatible 20 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionHaloperidol lactate Neuroleptic
Incompatible 0.2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Incompatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionIdarubicin hydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionLorazepam Anxiolytic
Incompatible 0.1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
Compatible 0.1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMannitol Various
Compatible 150 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMesna Cytoprotective
Compatible 10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMinocycline hydrochloride Antibiotic
Compatible 0.2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMitomycin Anticancer drug
Incompatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMitoxantrone dihydrochloride Anticancer drug
Compatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Incompatible 1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionOndansetron hydrochloride Antiemetic
Incompatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionPentostatin Anticancer drug
Compatible 0.4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionPiperacillin sodium Antibiotic
Incompatible 40 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionSargramostim Various
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible 10 µg/ml + NaHCO3
Compatible 10 µg/ml + Parenteral nutrition (binary mixture)
Incompatible 10 µg/ml + injectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionAmphotericin B 0.6 mg/ml + Glucose 5%
Incompatible 10 µg/ml + injectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionAmsacrine 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionAmsacrine 1 mg/ml + Glucose 5%
Compatible 10 µg/ml + injectionAztreonam 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionBleomycin sulfate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionButorphanol tartrate 0.04 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCalcium gluconate 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCarboplatin 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCarmustine 1.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionCefonicid sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionCefoperazone sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCeforanide 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCefuroxime sodium 30 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionChlormethine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionChlorpromazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCimetidine hydrochloride 12 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCisplatin 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionClindamycin phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCyclophosphamide 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionCytarabine 50 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDacarbazine 4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDactinomycin 10 µg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDiphenhydramine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDoxorubicin hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDoxycycline hyclate 1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionDroperidol 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionEtoposide 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionFloxuridine 3 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionFluorouracil 16 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionGanciclovir sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionHeparin sodium 100 UI/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionHydroxyzine dihydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionIdarubicin hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionIfosfamide 25 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMannitol 150 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMesna 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMethotrexate sodium 15 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMinocycline hydrochloride 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionMitomycin 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionMitoxantrone dihydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionNalbuphine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionNetilmicin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionOndansetron hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionPentostatin 0.4 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionPethidine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionPiperacillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionPotassium chloride 100 mEq/l + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionProchlorperazine edysilate 0.5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionPromethazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionRanitidine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionTeniposide 0.1 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionTicarcillin / clavulanic acid 31 mg/ml + Sodium chloride 0,9%
Incompatible 10 µg/ml + injectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionVancomycin hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionVinblastine sulfate 0.12 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionVincristine sulfate 0.05 mg/ml + Sodium chloride 0,9%
Compatible 10 µg/ml + injectionZidovudine 4 mg/ml + Sodium chloride 0,9%
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionTeniposide Anticancer drug
Compatible 0.1 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%
injectionZidovudine Antiviral
Compatible 4 mg/ml + injectionSargramostim 10 µg/ml + Sodium chloride 0,9%

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