Last update :
16/07/2021
References   References 3439  
Type : Journal

Research teams : Pampelone - University Hospital, Clinical Pharmacology Service
Authors : Parra M.A, Campanero M.A, S?daba B, Irigoyen A, Garc?a-L?pez L,Fernandez-Reyes M.J, Ramon Azanza J.
Title : Effect of Glucose Concentration on the Stability of Daptomycin in Peritoneal Solutions.
Reference : Perit Dial Int ; 33:458-461 2013

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
InjectionDaptomycin Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Degradation
Factors which affect stability Solvent Glucose 10% Induces Degradation
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 0.02 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Physionéal® 1.36 (Baxter) 0.02 mg/ml 37°C Not specified
6 Hour
Stability in solutions Polyvinyl chloride Physionéal® 2.27 (Baxter) 0.02 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Physionéal® 2.27 (Baxter) 0.02 mg/ml 37°C Not specified
6 Hour
Incompatible + Glucose 5%
Incompatible + Glucose 10%

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