Last update :
07/10/2024
References   References 57  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/3/294

Research teams : Hatfield - Mayron Research Laboratories
Authors : Mayron D, Gennaro AR.
Title : Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Reference : Am J Health-Syst Pharm ; 53: 294-304. 1996

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionCarboplatin Anticancer drug
Compatible 1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Compatible 16.7 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionChlormethine hydrochloride Anticancer drug
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 3 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCisplatin Anticancer drug
Compatible 0.05 & 1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCyclophosphamide Anticancer drug
Compatible 2 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionCytarabine Anticancer drug
Compatible 2 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionDacarbazine Anticancer drug
Compatible 1.7 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.24 mg/ml + injectionGranisetron hydrochloride 0.02 mg/ml + Water for Injection
Compatible 0.24 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionDoxorubicin hydrochloride Anticancer drug
Incompatible 0.2 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionFluorouracil Anticancer drug
Compatible 2 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionFurosemide Diuretic
Compatible 0.4 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionGentamicin sulfate Antibiotic
Compatible 1.5 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionGranisetron hydrochloride Antiemetic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Compatible 1 mg/ml + NaHCO3
Compatible 1 mg/ml + injectionCarboplatin 1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCeftazidime 16.7 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCisplatin 0.05 & 1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCyclophosphamide 2 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionCytarabine 2 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionDacarbazine 1.7 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionDexamethasone sodium phosphate 0.24 mg/ml + Water for Injection
Compatible 0.02 mg/ml + injectionDexamethasone sodium phosphate 0.24 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionDiphenhydramine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionDoxorubicin hydrochloride 0.2 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionEtoposide 0.4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionFluorouracil 2 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionFurosemide 0.4 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionGentamicin sulfate 1.5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionIfosfamide 4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMagnesium sulfate 16 mg/ml + Water for Injection
Compatible 1 mg/ml + injectionMesna 4 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMethotrexate sodium 12.5 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionPaclitaxel 0.29 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionPotassium chloride 40 mEq/l + Water for Injection
Compatible 1 mg/ml + injectionSodium bicarbonate 28.056 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionStreptozocin 9.1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionTicarcillin / clavulanic acid 26/0.89 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionVincristine sulfate 0.01 & 0.34 mg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionIfosfamide Anticancer drug
Compatible 4 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMagnesium sulfate Electrolyte
Compatible 16 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionMesna Cytoprotective
Compatible 4 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMethotrexate sodium Anticancer drug
Compatible 12.5 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionPaclitaxel Anticancer drug
Compatible 0.29 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 40 mEq/l + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
injectionSodium bicarbonate Electrolyte
Compatible 28.056 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionStreptozocin Anticancer drug
Compatible 9.1 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 26/0.89 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionVincristine sulfate Anticancer drug
Compatible 0.01 & 0.34 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Water for Injection 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Cyclophosphamide 1 mg/ml
4 Hour
Glass Water for Injection 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Cytarabine 1 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Magnesium sulfate 8 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Doxorubicin hydrochloride 0,1 mg/ml
2 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Cisplatin 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Diphenhydramine hydrochloride 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Dacarbazine 0,85 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Dexamethasone sodium phosphate 0,12 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Fluorouracil 1 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Furosemide 0,2 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Hydromorphone hydrochloride 0,25 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Lorazepam 0,05 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Methotrexate sodium 6,25 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Protect from light
injection Granisetron hydrochloride 0,5 mg/ml
injection Morphine sulfate 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Carboplatin 0,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Ceftazidime 8,35 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Cimetidine hydrochloride 1,5 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Etoposide 0,2 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Gentamicin sulfate 0,75 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Ifosfamide 2 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Chlormethine hydrochloride 0,25 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Mesna 2 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Paclitaxel 0,145 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Streptozocin 4,55 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Ticarcillin / clavulanic acid 13/0,45 mg/ml
4 Hour
Glass Sodium chloride 0,9% 20°C-23°C Light
injection Granisetron hydrochloride 0,5 mg/ml
injection Vincristine sulfate 0,005 mg/ml
4 Hour

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