Last update :
18/04/2024
Anticancer drug   Fluorouracil  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Acoflut Mexico
Adrucil United States of America
Eurofluor Germany
Fivocil India
Fivoflu India, Mexico
Fluorouracil Austria, Belgium, Brazil, Canada, Denmark, Finland, Great Britain, Greece, Hungary, Italy, Netherlands, Norway, Poland, Portugal, Republic of South Africa, Serbia, Spain, Switzerland, Turkey, United States of America
Fluorouracile France
Flurablastin Denmark, Finland, Norway, Sweden
Fluracedyl Belgium, Luxembourg, Malaysia, Netherlands
Fluroblastin Republic of South Africa
Fluroblastine Belgium
Flurox Mexico
Neofluor Germany
Neoflur Egypt
Oncofu Argentina
Ribofluor Germany
Triosules Argentina
Compatibility   Injection   Compatibility : Fluorouracil              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Fluorouracil 16 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Fluorouracil 16 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Immediate precipitation Incompatible
Injection Fluorouracil 16 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Fluorouracil 16 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
Injection Fluorouracil 16 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Chemical instability Incompatible
Injection Fluorouracil 1000 mg/ml
Injection Carboplatin 100 mg/ml
Glucose 5% 163
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Carboplatin
3474
Compatible
Injection Fluorouracil 0.5 mg/ml
Injection Cefalotin sodium 1 mg/ml
Glucose 5% 431
Chemical instability Incompatible
Injection Fluorouracil 10 mg/ml
Injection Cisplatin 0,5 mg/ml
Sodium chloride 0,9% 413
Chemical instability Incompatible
Injection Fluorouracil 1 mg/ml
Injection Cisplatin 0,2 mg/ml
Sodium chloride 0,9% 413
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Cisplatin
3474
Chemical instability Incompatible
Injection Fluorouracil
Injection Cisplatin
3578
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Cytarabine
3474
Chemical instability Incompatible
Injection Fluorouracil 0.25 mg/ml
Injection Cytarabine 0.4 mg/ml
Glucose 5% 431
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Cytarabine
3580
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Daunorubicin hydrochloride
3474
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Diazepam
3474
Compatible
Injection Fluorouracil 16 mg/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Chemical instability Incompatible
Injection Fluorouracil
Injection Doxorubicin hydrochloride
3645
Compatible
Injection Fluorouracil 50 mg/ml
Injection Doxorubicin hydrochloride 2 mg/ml
763
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Doxorubicin hydrochloride
3474
Compatible
Injection Fluorouracil 16 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
Injection Fluorouracil 50 mg/ml
Injection Droperidol 2,5 mg/ml
763
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Droperidol
3474
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Epirubicin hydrochloride
3474
Compatible
Injection Fluorouracil 16 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Chemical instability Incompatible
Injection Fluorouracil 1 & 16 mg/ml
Injection Fentanyl citrate 12.5 µg/ml
NaCl 0,9% or Glucose 5% 514
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Filgrastim
3474
Precipitation after 1 hour Incompatible
Injection Fluorouracil 16 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Fluorouracil 16 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Precipitation after 24 hours Incompatible
Injection Fluorouracil 50 mg/ml
Injection Folinate calcium 30.8 mg/ml
NaCl 0,9% or Glucose 5% 2181
Compatible
Injection Fluorouracil 6.5 mg/ml
Injection Folinate calcium 4 mg/ml
NaCl 0,9% or Glucose 5% 2181
Precipitation after 24 hours Incompatible
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Injection Folinate calcium 1.54 >> 13.33 mg/ml
Glucose 5% 155
Compatible
Injection Fluorouracil 50 mg/ml
Injection Folinate calcium 10 mg/ml
763
Compatible
Injection Fluorouracil 6.5 mg/ml
Injection Folinate calcium 30.8 mg/ml
2130
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Folinate calcium
3474
Immediate precipitation Incompatible
Injection Fluorouracil 50 mg/ml
Injection Folinate calcium 30.8 mg/ml
2130
Precipitation after 24 hours Incompatible
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Injection Folinate calcium 1.54 >> 13.33 mg/ml
None 155
Compatible
Injection Fluorouracil 50 mg/ml
Injection Furosemide 10 mg/ml
763
Immediate precipitation Incompatible
Injection Fluorouracil 50 mg/ml
Injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Compatible
Injection Fluorouracil 16 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Fluorouracil 2 mg/ml
Injection Granisetron hydrochloride 1 mg/ml
Water for Injection 57
Compatible
Injection Fluorouracil 16 mg/ml
Injection Granisetron hydrochloride 0,05 mg/ml
Glucose 5% 49
Compatible
Injection Fluorouracil 16 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Immediate turbidity Incompatible
Injection Fluorouracil 16 mg/ml
Parenteral nutrition (binary mixture) 301
Unspecified incompatibility Incompatible
Injection Fluorouracil
Parenteral nutrition (binary mixture) 3474
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Gallium nitrate
3474
Compatible
Injection Fluorouracil 50 mg/ml
Injection Heparin sodium 1 UI/ml
Ringer’s lactate solution 1228
Compatible
Injection Fluorouracil 50 mg/ml
Injection Heparin sodium 1000 UI/ml
763
Compatible
Injection Fluorouracil 50 mg/ml
Injection Heparin sodium 1 UI/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Fluorouracil 0,8 mg/ml
Injection Heparin sodium 5 UI/ml
NaCl 0,9% or Glucose 5% 156
Compatible
Injection Fluorouracil 24 mg/ml
Injection Heparin sodium 960 UI/ml
Glucose 5% 163
Compatible
Injection Fluorouracil 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
Ringer’s lactate solution 1228
Compatible
Injection Fluorouracil 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Fluorouracil 1 & 16 mg/ml
Injection Hydromorphone hydrochloride 0.5 mg/ml
NaCl 0,9% or Glucose 5% 513
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Idarubicin hydrochloride
3474
Precipitation after 15 minutes Incompatible
Injection Fluorouracil 25 mg/ml
Injection Irinotecan 2 mg/ml
Sodium chloride 0,9% 3873
Precipitation after 4 hours Incompatible
Injection Fluorouracil 16 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Precipitation after 24 hours Incompatible
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Injection Levofolinate calcium 1.54 >> 13.33 mg/ml
Glucose 5% 155
Precipitation after 24 hours Incompatible
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Injection Levofolinate calcium 1.54 >> 13.33 mg/ml
None 155
Compatible
Injection Fluorouracil 1 mg/ml
Parenteral nutrition (binary mixture) 1325
Chemical instability Incompatible
Injection Fluorouracil 6.5 mg/ml
Injection Levofolinate calcium 4 mg/ml
NaCl 0,9% or Glucose 5% 2181
Compatible
Injection Fluorouracil 50 mg/ml
Injection Levofolinate calcium 15.4 mg/ml
NaCl 0,9% or Glucose 5% 2181
Immediate precipitation Incompatible
Injection Fluorouracil 50 mg/ml
Injection Levofolinate calcium 15.4 mg/ml
2130
Compatible
Injection Fluorouracil 6.5 mg/ml
Injection Levofolinate calcium 15.4 mg/ml
2130
Compatible
Injection Fluorouracil 10,8 mg/ml
Injection Levofolinate calcium 1,8 mg/ml
NaCl 0,9% or Glucose 5% 3369
Compatible
Injection Fluorouracil 16 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Fluorouracil 1 & 2 mg/ml
Injection Mannitol 200 mg/ml
Sodium chloride 0,9% 411
Compatible
Injection Fluorouracil 16 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Chemical instability Incompatible
Injection Fluorouracil 0.25 mg/ml
Injection Methotrexate sodium 0.2 mg/ml
Glucose 5% 431
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Methotrexate sodium
3474
Compatible
Injection Fluorouracil 50 mg/ml
Injection Methotrexate sodium 25 mg/ml
763
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Methotrexate sodium
3637
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Metoclopramide hydrochloride
3474
Compatible
Injection Fluorouracil 2,5 mg/ml
Injection Metoclopramide hydrochloride 0,1 mg/ml
Glucose 5% 153
Compatible
Injection Fluorouracil 50 mg/ml
Injection Metoclopramide hydrochloride 5 mg/ml
763
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Morphine hydrochloride
3474
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Morphine sulfate
3474
Immediate precipitation Incompatible
Injection Fluorouracil 1 & 16 mg/ml
Injection Morphine sulfate 1 mg/ml
NaCl 0,9% or Glucose 5% 513
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Morphine sulfate
3531
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Morphine tartrate
3474
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Ondansetron hydrochloride
3474
Immediate precipitation Incompatible
Injection Fluorouracil 16 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Fluorouracil < 0,8 mg/ml
Injection Ondansetron hydrochloride 0,016 >> 0,16 mg/ml
3574
Immediate precipitation Incompatible
Injection Fluorouracil > 0,8 mg/ml
Injection Ondansetron hydrochloride 0,016 >> 0,16 mg/ml
3574
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Oxaliplatin
3634
Compatible
Injection Fluorouracil 16 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 85
Compatible
Injection Fluorouracil 16 mg/ml
Injection Palonosetron hydrochloride 50 µg/ml
Glucose 5% 2009
Compatible
Injection Fluorouracil 16 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Fluorouracil 16 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Fluorouracil 50 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 1228
Compatible
Injection Fluorouracil 50 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Fluorouracil 16 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Fluorouracil 16 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Fluorouracil 16 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Fluorouracil 16 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Fluorouracil 50 mg/ml
Injection Topotecan 0.056 mg/ml
Glucose 5% 1026
Immediate turbidity Incompatible
Injection Fluorouracil 50 mg/ml
Injection Topotecan 0.056 mg/ml
Sodium chloride 0,9% 1026
Compatible
Injection Fluorouracil 50 mg/ml
Injection Vinblastine sulfate 1 mg/ml
763
Compatible
Injection Fluorouracil 0.010 mg/ml
Injection Vincristine sulfate 0.004 mg/ml
Glucose 5% 431
Compatible
Injection Fluorouracil 50 mg/ml
Injection Vincristine sulfate 1 mg/ml
763
Immediate precipitation Incompatible
Injection Fluorouracil 16 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84
Compatible
Injection Fluorouracil < 12.5 mg/ml
Parenteral nutrition (with lipids) 3948
Immediate precipitation Incompatible
Injection Fluorouracil 25 & 50 mg/ml
Parenteral nutrition (with lipids) 3948
Immediate precipitation Incompatible
Injection Fluorouracil 25 & 50 mg/ml
Parenteral nutrition (with lipids) 3948
Unspecified incompatibility Incompatible
Injection Fluorouracil
Parenteral nutrition (with lipids) 3474
Immediate precipitation Incompatible
Injection Fluorouracil 16 mg/ml
Parenteral nutrition (with lipids) 1415
Unspecified incompatibility Incompatible
Injection Fluorouracil
Injection Vinorelbine tartrate
3474
Compatible
Injection Fluorouracil < 12.5 mg/ml
Parenteral nutrition (binary mixture) 3948

  Mentions Légales