Last update :
21/02/2024
Antihistamine (H1)   Diphenhydramine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Benadryl
Benison Turkey
Dibondrin Austria
Compatibility   Injection   Compatibility : Diphenhydramine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Aciclovir sodium 5 mg/ml
Sodium chloride 0,9% 2335
Compatible
Injection Diphenhydramine hydrochloride 1 mg/ml
Injection Aciclovir sodium 5 mg/ml
Glucose 5% 336
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Aldesleukin 0.0338 MUI/ml
Glucose 5% 36
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Color change Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Amsacrine 1 mg/ml
Glucose 5% 253
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Argatroban 1 mg/ml
Sodium chloride 0,9% 1964
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Azithromycine 2 mg/ml
Sodium chloride 0,9% 1800
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Caspofungin acetate 0.5 mg/ml
Sodium chloride 0,9% 2233
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Cefmetazole sodium 100 mg/ml
Water for Injection 93
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Unspecified incompatibility Incompatible
Injection Diphenhydramine hydrochloride
Injection Ceftobiprole medocaril sodium
4650
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
Ringer’s lactate solution 2269
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Chlorpromazine hydrochloride 25 mg/ml
188
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Cimetidine hydrochloride 150 mg/ml
1438
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 288
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
Injection Diphenhydramine hydrochloride < 5 mg/ml
Injection Dexamethasone sodium phosphate 4 >> 10 mg/ml
389
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 5 >> 35 mg/ml
Injection Dexamethasone sodium phosphate 2 >> 10 mg/ml
389
Compatible
Injection Diphenhydramine hydrochloride 40 mg/ml
Injection Dexamethasone sodium phosphate 2 mg/ml
389
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Diatrizoate meglumine 283 mg/ml
None 1085
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Famotidine 2 mg/ml
Sodium chloride 0,9% 215
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Fentanyl citrate 25 µg/ml
Glucose 5% 1974
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Immediate turbidity Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Foscarnet sodium 24 mg/ml
None 73
Immediate turbidity Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Diphenhydramine hydrochloride 1 mg/ml
Injection Granisetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 57
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride
Injection Haloperidol lactate
985
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Heparin sodium 1 UI/ml
Ringer’s lactate solution 1228
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Ringer’s lactate solution 4603
Compatible
Injection Diphenhydramine hydrochloride 2 & 50 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Heparin sodium 1 UI/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Diphenhydramine hydrochloride 2 & 50 mg/ml
Parenteral nutrition (binary mixture) 301
Precipitation after 2 hours Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Haloperidol lactate 5 mg/ml
982
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Haloperidol lactate 5 mg/ml
188
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
Ringer’s lactate solution 1228
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Hydromorphone hydrochloride 0.5 mg/ml
Glucose 5% 1974
Compatible
Injection Diphenhydramine hydrochloride 1 & 50 mg/ml
Injection Idarubicin hydrochloride 1 mg/ml
Sodium chloride 0,9% 491
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Iohexol 300 mg I/ml
None 1085
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Ioxaglate 320 mg I/ml
None 1085
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Ketamine hydrochloride 50 mg/ml
2109
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Meropenem 1 & 50 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Diphenhydramine hydrochloride 0.08 mg/ml
Injection Meropenem 1 & 20 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Methadone hydrochloride 1 mg/ml
Glucose 5% 1974
Compatible
Injection Diphenhydramine hydrochloride 25 mg/ml
Injection Midazolam hydrochloride 2.5 mg/ml
None 404
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 1974
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection N-acetylcysteine 200 mg/ml
None 3766
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Diphenhydramine hydrochloride 0.4 mg/ml
Injection Netilmicin sulfate 3 mg/ml
NaCl 0,9% or Glucose 5% 1200
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 85
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride
Injection Pantoprazole sodium
2090
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Paracetamol 10 mg/ml
None 3571
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Paracetamol 10 mg/ml
4742
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Diphenhydramine hydrochloride 1&50 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 62
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 1228
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Ranitidine hydrochloride 25 mg/ml
None 58
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Compatible
Injection Diphenhydramine hydrochloride 1 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Diphenhydramine hydrochloride 1 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Turbidity in 2 hours Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Immediate precipitation Incompatible
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

  Mentions Légales