Last update :
21/09/2021
Antibiotic   Imipenem - cilastatin sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Arzomeba Chile
Bacqure Ecuador, Morocco, Peru
Betatrexil Ecuador
Cilanem Chile
Cilapem Turkey
Conet Slovenia
Gimipen Colombia
Imacina Chile
Imipen Italy
Imistatin Argentina
Linataz Colombia
Perloyem Argentina
Primaxin Australia, Canada, Great Britain, Greece, New Zealand, Peru, United States of America
Silanem Turkey
Silpen Chile
Tenacid Italy
Tesilan Colombia
Tienam Belgium, Chile, Colombia, Croatia, Denmark, Ecuador, Egypt, Finland, France, Germany, Hungary, Iran, Ireland, Italy, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, Norway, Peru, Poland, Portugal, Republic of South Africa, Romania, Saudi Arabia, Spain, Sweden, Switzerland, Thailand, Tunisia, Turkey, United Arab Emirates
Zienam Argentina, Austria, Germany, Venezuela
Compatibility   Injection   Compatibility : Imipenem - cilastatin sodium        
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
Injection Imipenem - cilastatin sodium
NaHCO3 21
Chemical instability Incompatible
Injection Imipenem - cilastatin sodium 0.5 mg/ml
Parenteral nutrition (binary mixture) 1103
Unspecified incompatibility Incompatible
Injection Imipenem - cilastatin sodium
Ringer’s lactate solution 3530
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Parenteral nutrition (with lipids) 4440
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Aciclovir sodium 5 mg/ml
Glucose 5% 336
Color change Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Parenteral nutrition (binary mixture) 898
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Imipenem - cilastatin sodium
Parenteral nutrition (binary mixture) 3985
Precipitation after 1 hour Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Chemical instability Incompatible
Injection Imipenem - cilastatin sodium
Injection Amikacin sulfate
3549
Immediate turbidity Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Amiodarone hydrochloride 6 mg/ml
Glucose 5% 1611
Color change after 2 hours Incompatible
Injection Imipenem - cilastatin sodium 4/4 mg/ml
Injection Amoxicillin sodium 8 mg/ml
Sodium chloride 0,9% 2349
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Azithromycine 2 mg/ml
Sodium chloride 0,9% 1800
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 50 mg/ml
Injection Cefoxitin sodium 100 mg/ml
4389
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Colistin mesilate sodium 1.5 mg/ml
Sodium chloride 0,9% 3997
Unspecified incompatibility Incompatible
Injection Imipenem - cilastatin sodium 9.94/9.94 mg/ml
Injection Defibrotide 8 mg/ml
Glucose 5% 3728
Compatible
Injection Imipenem - cilastatin sodium 9.94/9.94 mg/ml
Injection Defibrotide 8 mg/ml
Sodium chloride 0,9% 3728
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Enalaprilate 0.0125 mg/ml
Sodium chloride 0,9% 1703
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Unspecified incompatibility Incompatible
Injection Imipenem - cilastatin sodium
Injection Erythromycin lactobionate
3674
Color change after 4 hours Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Etoposide phosphate 5 mg/ml
Sodium chloride 0,9% 1410
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Famotidine
Glucose 5% 397
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Chemical instability Incompatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Filgrastim 40 µg/ml
Glucose 5% 104
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Foscarnet sodium 24 mg/ml
None 73
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Foscarnet sodium 24 mg/ml
Glucose 5% 1135
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Immediate precipitation Incompatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Color change after 1 hour Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Precipitation after 24 hours Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Idarubicin hydrochloride 1 mg/ml
Sodium chloride 0,9% 491
Unspecified incompatibility Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Insulin aspart 1 UI/ml
NaCl 0,9% or Glucose 5% 1508
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Turbidity in 4 hours Incompatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Precipitation after 24 hours Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Lorazepam 0.33 mg/ml
Sodium chloride 0,9% 186
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Imipenem - cilastatin sodium 50 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Turbidity in 24 hours Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Midazolam hydrochloride 5 mg/ml
None 186
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Color change after 2 hours Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 62
Compatible
Injection Imipenem - cilastatin sodium 2,5 mg/ml
Injection Phloroglucinol 2,5 mg/ml
3791
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Propofol 10 mg/ml
None 300
Immediate instability of the emulsion Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Propofol
660
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Precipitation after 4 hours Incompatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Chemical instability Incompatible
Injection Imipenem - cilastatin sodium 250 & 500 mg/ml
Injection Sodium bicarbonate 50 mg/ml
21
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Ringer’s lactate solution 3254
Turbidity in one hour Incompatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Telavancin hydrochloride 7,5 mg/ml
Glucose 5% 3254
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Sodium chloride 0,9% 3254
Unspecified incompatibility Incompatible
Injection Imipenem - cilastatin sodium
Injection Temocilline
4470
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Injection Vasopressin 0.2 UI/ml
Sodium chloride 0,9% 2017
Compatible
Injection Imipenem - cilastatin sodium 10 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84
Compatible
Injection Imipenem - cilastatin sodium 5 mg/ml
Injection Zidovudine 4 mg/ml
Glucose 5% 337

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