Last update :
16/06/2024
Antidote   Nalbuphine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Alambuphine Egypt
Bufidol Venezuela
Bufigen Mexico
Bufilem Mexico
Bufinest Mexico
Fabitec Mexico
Gobbinal Argentina
Intapan Malaysia
Metanolone Mexico
Nalbufin Egypt, Sweden
Nalbufina Argentina, Chile, Mexico
Nalbuphin Switzerland
Nalbuphine Egypt, Romania, United States of America
Nalcryn Mexico
Nalfy India
Nalpain Egypt, Germany, Sweden
Naphine Malaysia
Nubain Austria, Canada, Chile, Germany, Great Britain, Greece, Hungary, Luxembourg, Netherlands, Switzerland, United Arab Emirates, United States of America
Nubaina Argentina
Onfor Argentina
Compatibility   Injection   Compatibility : Nalbuphine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Aciclovir sodium 5 mg/ml
Sodium chloride 0,9% 2335
Precipitation after 1 hour Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0,83 mg/ml
Glucose 5% 921
Compatible
Injection Nalbuphine hydrochloride 5 & 10 mg/ml
Injection Atropine sulfate 0,2 & 0,5 mg/ml
616
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 1 mg/ml
Injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
Injection Nalbuphine hydrochloride 1 mg/ml
Injection Cefmetazole sodium 100 mg/ml
Water for Injection 93
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Cimetidine hydrochloride 150 mg/ml
1438
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
Injection Nalbuphine hydrochloride 2 mg/ml
Injection Defibrotide 8 mg/ml
Sodium chloride 0,9% 3728
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Unspecified incompatibility Incompatible
Injection Nalbuphine hydrochloride
Injection Diazepam
3672
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 2,5 >> 10 mg/ml
Injection Diazepam 5 mg/ml
616
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Immediate instability of the emulsion Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Parenteral nutrition (with lipids) 1415
Immediate turbidity Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Nalbuphine hydrochloride 5 & 10 mg/ml
Injection Droperidol 2,5 & 5 mg/ml
616
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Parenteral nutrition (binary mixture) 301
Production of gas bubbles Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
NaHCO3 150
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Nalbuphine hydrochloride 2,5 >> 10 mg/ml
Injection Hydroxyzine dihydrochloride 50 mg/ml
616
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Ketorolac tromethamine 30 mg/ml
None 476
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Methotrexate sodium 30 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Nalbuphine hydrochloride 5 mg/ml
Injection Midazolam hydrochloride 2.5 mg/ml
None 404
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Nafcillin sodium 33 mg/ml
Sodium chloride 0,9% 1366
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 248
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Paracetamol 10 mg/ml
None 3571
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 2,5 >> 10 mg/ml
Injection Pentobarbital sodium 25 & 50 mg/ml
616
Immediate turbidity Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Nalbuphine hydrochloride 2,5 >> 10 mg/ml
Injection Prochlorperazine edysilate 5 mg/ml
616
Compatible
Injection Nalbuphine hydrochloride 5 & 10 mg/ml
Injection Promethazine hydrochloride 12,5 & 25 mg/ml
616
Unspecified incompatibility Incompatible
Injection Nalbuphine hydrochloride
Injection Promethazine hydrochloride
3672
Immediate precipitation Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Promethazine hydrochloride 25 mg/ml
518
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Ranitidine hydrochloride 25 mg/ml
None 58
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Turbidity in 30 minutes Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Nalbuphine hydrochloride 5 & 10 mg/ml
Injection Scopolamine hydrobromide 0,46 & 0,83 mg/ml
616
Production of gas bubbles Incompatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Sodium bicarbonate 14 mg/ml
None 150
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

  Mentions Légales