Last update :
18/04/2024
Antibiotic   Co-trimoxazole  
Injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bactrim Argentina, Brazil, Colombia, France, Italy, Poland, Republic of South Africa, Saudi Arabia, Sweden, Switzerland, Turkey, United Arab Emirates
Bactrimel Chile, Greece, Netherlands, Venezuela
Biseptol Poland, Russian
Cotrim Finland, Germany, Iran
Cotrimoxazol Chile, Portugal
Cotrimoxazole Great Britain
Cotrizol Argentina
Danferane Argentina
Eusaprim Austria, Belgium, Germany, Luxembourg, Sweden
Nopil Switzerland
Novidrine Argentina
Pisatrina Mexico
Septa Canada
Septra Canada
Septrin Chile, Great Britain, Greece, Ireland, Poland, Portugal, Saudi Arabia, Turkey, United Arab Emirates
Soltrim Spain
Spectrex Argentina
Trimexazole Mexico
Compatibility   Injection   Compatibility : Co-trimoxazole              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Aciclovir sodium 5 mg/ml
Glucose 5% 336
Compatible
Injection Co-trimoxazole
Injection Aldesleukin 0.0338 MUI/ml
Glucose 5% 36
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Compatible
Injection Co-trimoxazole 16/80 mg/ml
Injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
Injection Co-trimoxazole 3.2/0.64 mg/ml
Injection Atracurium besylate 0.5 mg/ml
Glucose 5% 402
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Immediate precipitation Incompatible
Injection Co-trimoxazole 3.2 mg/ml
Injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
Injection Co-trimoxazole 16/80 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Immediate precipitation Incompatible
Injection Co-trimoxazole 4/0,8 mg/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Turbidity in one hour Incompatible
Injection Co-trimoxazole 3.2/0.64 & 80/16 mg/ml
Injection Cefazolin sodium 41.6 mg/ml
Glucose 5% 4254
Compatible
Injection Co-trimoxazole 4/0,8 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Compatible
Injection Co-trimoxazole 4/0,8 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
Ringer’s lactate solution 2269
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Immediate turbidity Incompatible
Injection Co-trimoxazole 0,8/4 mg/ml
Injection Cisatracurium besylate 2 & 5 mg/ml
Glucose 5% 299
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Cisatracurium besylate 0.1 mg/ml
Glucose 5% 299
Subvisual incompatibility Incompatible
Injection Co-trimoxazole 80/16 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
Injection Daunorubicin/cytarabine liposomale
4354
Immediate turbidity Incompatible
Injection Co-trimoxazole
Injection Daunorubicin/cytarabine liposomale 0,4 mg/mL
Sodium chloride 0,9% 4654
Compatible
Injection Co-trimoxazole 0.64/3.2 mg/ml
Injection Defibrotide 8 mg/ml
Sodium chloride 0,9% 3728
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Co-trimoxazole 0.21 & 0.63 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Co-trimoxazole
Injection Dimenhydrinate
2087
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Co-trimoxazole 0.64/3.2 mg/ml
Injection Esmolol hydrochloride 10 mg/ml
Glucose 5% 384
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Immediate precipitation Incompatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Fluconazole 2 mg/ml
None 256
Compatible
Injection Co-trimoxazole 2,6/0,53 mg/ml
Injection Foscarnet sodium 24 mg/ml
Glucose 5% 1135
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
NaHCO3 3583
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
Injection Foscarnet sodium
3662
Incompatible
Injection Co-trimoxazole
Dianéal® PD2 4.25% glucose (Baxter) 2162
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Parenteral nutrition (binary mixture) 301
Immediate precipitation Incompatible
Injection Co-trimoxazole
Injection Foscarnet sodium 24 mg/ml
None 73
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Co-trimoxazole 0.8/1.6 mg/ml
Injection Enalaprilate 0.05 mg/ml
Sodium chloride 0,9% 1315
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Precipitation after 4 hours Incompatible
Injection Co-trimoxazole 3.2/0.64 & 80/16 mg/ml
Injection Heparin sodium 208 UI/ml
NaCl 0,9% or Glucose 5% 4254
Compatible
Injection Co-trimoxazole 0,76/3,81 mg/ml
Parenteral nutrition (with lipids) 4440
Immediate precipitation Incompatible
Injection Co-trimoxazole 16 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Compatible
Injection Co-trimoxazole 4/0,8 mg/ml
Injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Hydromorphone hydrochloride 0.2 mg/ml
Glucose 5% 405
Turbidity in one hour Incompatible
Injection Co-trimoxazole 3.2/0.64 & 80/16 mg/ml
Injection Insulin 1 UI/ml
NaCl 0,9% or Glucose 5% 4254
Immediate precipitation Incompatible
Injection Co-trimoxazole 80/16 mg/ml
Injection Ketamine hydrochloride 50 mg/ml
2109
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Labetalol hydrochloride 1 mg/ml
Glucose 5% 386
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Immediate precipitation Incompatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Linezolid 2 mg/ml
None 1607
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
Injection Linezolid
3560
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Lorazepam 0.33 mg/ml
Sodium chloride 0,9% 186
Compatible
Injection Co-trimoxazole 0.8/40 mg/ml
Injection Magnesium sulfate 16.67 >> 100 mg/ml
Glucose 5% 1047
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Co-trimoxazole 80/16 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Immediate precipitation Incompatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Midazolam hydrochloride 5 mg/ml
None 186
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 405
Compatible
Injection Co-trimoxazole 16/80 mg/ml
Injection N-acetylcysteine 200 mg/ml
None 3766
Compatible
Injection Co-trimoxazole
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Co-trimoxazole 0.8/1.6 mg/ml
Injection Nicardipine hydrochloride 0.1 mg/ml
NaCl 0,9% or Glucose 5% 1490
Precipitation after 1 hour Incompatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Compatible
Injection Co-trimoxazole 3.2/0.64 mg/ml
Injection Pancuronium bromide 0.05 mg/ml
Glucose 5% 402
Precipitation after 1 hour Incompatible
Injection Co-trimoxazole
Injection Pantoprazole sodium
2090
Compatible
Injection Co-trimoxazole 16/80 mg/ml
Injection Paracetamol 10 mg/ml
4742
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Co-trimoxazole 4/0.8 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 405
Immediate precipitation Incompatible
Injection Co-trimoxazole 12 mg/ml
Injection Phloroglucinol 2,5 mg/ml
3791
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
Injection Rocuronium bromide
3564
Immediate precipitation Incompatible
Injection Co-trimoxazole 16/80 mg/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Unspecified incompatibility Incompatible
Injection Co-trimoxazole
Injection Sodium bicarbonate
3583
Compatible
Injection Co-trimoxazole 16/8 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Co-trimoxazole 16/80 mg/ml
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Compatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Co-trimoxazole 3.2/0.64 mg/ml
Injection Vecuronium bromide 0.1 mg/ml
Glucose 5% 402
Immediate precipitation Incompatible
Injection Co-trimoxazole 0.16/0.8 mg/ml
Injection Verapamil hydrochloride 0.08 mg/ml
NaCl 0,9% or Glucose 5% 1057
Immediate turbidity Incompatible
Injection Co-trimoxazole 0.8/4 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84
Compatible
Injection Co-trimoxazole 0.53/2.6 mg/ml
Injection Zidovudine 4 mg/ml
Glucose 5% 337

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