Last update :
17/04/2024
Anti-inflammatory   Methylprednisolone sodium succinate  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Methylprednisolone France
Metypred Poland
Prednol Turkey
Solomet Finland
Solu-Medrol Austria, Brazil, Canada, Croatia, Denmark, Finland, France, Italy, Netherlands, Norway, Poland, Portugal, Republic of South Africa, Slovenia, Sweden, Switzerland, United States of America
Solu-Medrone Great Britain, Ireland
Urbason Austria, Italy, Spain
Compatibility   Injection   Compatibility : Methylprednisolone sodium succinate              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Methylprednisolone sodium succinate 0.8 mg/ml
Injection Aciclovir sodium 5 mg/ml
Glucose 5% 336
Turbidity in one hour Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Methylprednisolone sodium succinate 40 mg/ml
Injection Alprostadil 15 µg/ml
3201
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Chemical instability Incompatible
Injection Methylprednisolone sodium succinate 0,5 & 2 mg/ml
Injection Aminophylline 1 mg/ml
NaCl 0,9% or Glucose 5% 390
Compatible
Injection Methylprednisolone sodium succinate 125 mg/ml
Injection Amiodarone hydrochloride 6 mg/ml
Glucose 5% 1611
Unspecified incompatibility Incompatible
Injection Methylprednisolone sodium succinate
Injection Amoxicillin sodium / clavulanic acid
3545
Incompatible
Injection Methylprednisolone sodium succinate 125 mg/ml
Injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Amsacrine 1 mg/ml
Glucose 5% 253
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
Injection Methylprednisolone sodium succinate 0,2 mg/ml
Injection Atenolol 0,1 mg/ml
Sodium chloride 0,9% 4698
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
Injection Methylprednisolone sodium succinate 500 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 62.5 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 288
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Cisatracurium besylate 0.1 mg/ml
Glucose 5% 299
Compatible
Injection Methylprednisolone sodium succinate 62,5 mg/ml
Ringer’s lactate solution 4603
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Cisatracurium besylate 2 & 5 mg/ml
Glucose 5% 299
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
Ringer’s lactate solution 2269
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Compatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Methylprednisolone sodium succinate 0.4 mg/ml
Injection Cimetidine hydrochloride 3 mg/ml
Glucose 5% 1201
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 0,2 mg/ml
Injection Clonidine hydrochloride 0,0125 mg/ml
Sodium chloride 0,9% 4698
Compatible
Injection Methylprednisolone sodium succinate 0.058 >> 0.080 mg/ml
Parenteral nutrition (with lipids) 1868
Compatible
Injection Methylprednisolone sodium succinate 62.5 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Cytarabine 16 mg/ml
NaCl 0,9% or Glucose 5% 132
Unspecified incompatibility Incompatible
Injection Methylprednisolone sodium succinate
Injection Cytarabine
3580
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate
Injection Daunorubicin hydrochloride
3604
Compatible
Injection Methylprednisolone sodium succinate 10 mg/ml
Injection Defibrotide 8 mg/ml
Sodium chloride 0,9% 3728
Unspecified incompatibility Incompatible
Injection Methylprednisolone sodium succinate 10 mg/ml
Injection Defibrotide 8 mg/ml
Glucose 5% 3728
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Methylprednisolone sodium succinate 2.5 >> 62.5 mg/ml
Injection Diltiazem hydrochloride 1 mg/ml
Sodium chloride 0,9% 198
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 2.5 >> 62.5 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Loss of turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Methylprednisolone sodium succinate 0.5 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
Glucose 5% 738
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
Glucose 5% 132
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Methylprednisolone sodium succinate 0.8 mg/ml
Injection Enalaprilate 0.05 mg/ml
Sodium chloride 0,9% 1315
Compatible
Injection Methylprednisolone sodium succinate 1 mg/ml
Injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
Injection Methylprednisolone sodium succinate 40 mg/ml
Injection Famotidine
Glucose 5% 397
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Parenteral nutrition (binary mixture) 301
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Methylprednisolone sodium succinate 0,7 mg/ml
Injection Fosaprepitant dimeglumine 1 mg/ml
Sodium chloride 0,9% 3459
Compatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Compatible
Injection Methylprednisolone sodium succinate 2.26 & 6 mg/ml
Injection Granisetron hydrochloride 0.056 & 0.15 mg/ml
NaCl 0,9% or Glucose 5% 29
Compatible
Injection Methylprednisolone sodium succinate 2.5 mg/ml
Injection Heparin sodium 50 UI/ml
None 317
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Heparin sodium 100 UI/ml
NaCl 0,9% or Glucose 5% 132
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Compatible
Injection Methylprednisolone sodium succinate 10 mg/ml
Injection Iohexol 300 mg I/ml
None 1085
Compatible
Injection Methylprednisolone sodium succinate 10 mg/ml
Injection Ioxaglate 320 mg I/ml
None 1085
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Methylprednisolone sodium succinate 0.4 mg/ml
Injection Ketoprofene 3.2 mg/ml
Sodium chloride 0,9% 1847
Precipitation after 4 hours Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Methylprednisolone sodium succinate 62.5 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Metronidazole 5 mg/ml
Glucose 5% 132
Compatible
Injection Methylprednisolone sodium succinate 40 mg/ml
Injection Midazolam hydrochloride 1 mg/ml
Glucose 5% 176
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 0.1 >> 9 mg/ml
Injection Morphine hydrochloride 10 >> 50 mg/ml
Sodium chloride 0,9% 1866
Compatible
Injection Methylprednisolone sodium succinate 0.1 >> 9 mg/ml
Injection Morphine hydrochloride <10 mg/ml
Sodium chloride 0,9% 1866
Compatible
Injection Methylprednisolone sodium succinate 2.5 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 62
Compatible
Injection Methylprednisolone sodium succinate 0.8 mg/ml
Injection Nicardipine hydrochloride 0.1 mg/ml
NaCl 0,9% or Glucose 5% 1490
Turbidity in 30 minutes Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Methylprednisolone sodium succinate 2,4 mg/ml
Injection Ondansetron hydrochloride 0,16 mg/ml
Glucose 5% 2012
Compatible
Injection Methylprednisolone sodium succinate 2,4 mg/ml
Injection Ondansetron hydrochloride 0,16 mg/ml
Sodium chloride 0,9% 2012
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Loss of turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 248
Precipitation after 4 hours Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Palonosetron hydrochloride 50 µg/ml
Glucose 5% 2107
Compatible
Injection Methylprednisolone sodium succinate 62.5 mg/ml
Injection Paracetamol 10 mg/ml
4742
Compatible
Injection Methylprednisolone sodium succinate 62.5 mg/ml
Injection Paracetamol 10 mg/ml
None 3571
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
Injection Methylprednisolone sodium succinate
Injection Penicillin G sodium
3585
Compatible
Injection Methylprednisolone sodium succinate 2.5 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 62
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 0,4 mg/ml
Injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 40 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 730
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 40 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 730
Instability of the emulsion after 6 hours Incompatible
Injection Methylprednisolone sodium succinate 63 mg/ml
Injection Propofol
660
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Methylprednisolone sodium succinate 0.04 & 2 mg/ml
Injection Ranitidine hydrochloride 0.05 & 2 mg/ml
NaCl 0,9% or Glucose 5% 210
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Unspecified incompatibility Incompatible
Injection Methylprednisolone sodium succinate
Injection Rocuronium bromide
3564
Precipitation after 4 hours Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Methylprednisolone sodium succinate 0,8 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Compatible
Injection Methylprednisolone sodium succinate 20 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Ringer’s lactate solution 3254
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Sodium chloride 0,9% 3254
Immediate turbidity Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Telavancin hydrochloride 7,5 mg/ml
Glucose 5% 3254
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Methylprednisolone sodium succinate 2.5 mg/ml
Injection Theophylline 4 mg/ml
None 317
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Methylprednisolone sodium succinate 2.4 mg/ml
Injection Topotecan 0.056 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Valproic acid 2 & 20 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
Injection Methylprednisolone sodium succinate 0.25 mg/ml
Injection Verapamil hydrochloride 0.08 mg/ml
NaCl 0,9% or Glucose 5% 1057
Immediate precipitation Incompatible
Injection Methylprednisolone sodium succinate 5 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

  Mentions Légales