Last update :
15/10/2021
Antihistamine (H1)   Promethazine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Atosil Germany
Chemoprozin Iran
Diphergan Poland
Farganesse Italy
Fenergan Argentina, Brazil, Portugal
Frinova Spain
Phenergan Australia, Belgium, France, Great Britain, Iran, Ireland, Luxembourg, Morocco, Netherlands, United States of America
Pipolphen Hungary
Promethazin Germany
Promethazina Argentina
Promethazine Australia, Canada, Great Britain, Iran, Ireland, Malaysia, Netherlands, United States of America
Promethazine hydrochloride Malaysia, New Zealand
Protazin Germany
Titanox Greece
Compatibility   Injection   Compatibility : Promethazine hydrochloride        
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Aldesleukin 0.0338 MUI/ml
Glucose 5% 36
Immediate turbidity Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0,83 mg/ml
Glucose 5% 921
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Amsacrine 1 mg/ml
Glucose 5% 253
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Bivalirudin
3539
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Bivalirudin
3539
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Cefazolin sodium 10 mg/ml
Glucose 5% 103
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Cefmetazole sodium 100 mg/ml
Water for Injection 93
Immediate precipitation Incompatible
Injection Promethazine hydrochloride
Injection Cefoperazone sodium
Glucose 5% 1739
Immediate precipitation Incompatible
Injection Promethazine hydrochloride
Injection Cefoperazone sodium
Glucose 5% 106
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Ceftizoxime sodium 10 mg/ml
Glucose 5% 103
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Ceftobiprole 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Ceftobiprole 2 mg/ml
Ringer’s lactate solution 2269
Color change Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Chloroquine phosphate 50 mg/ml
None 124
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Cimetidine hydrochloride 150 mg/ml
1438
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 288
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Promethazine hydrochloride 12,5 & 25 mg/ml
Injection Dihydroergotamine mesilate 0,5 mg/ml
None 1069
Color change after 1 hour Incompatible
Injection Promethazine hydrochloride
Injection Dimenhydrinate
2087
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Immediate turbidity Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Erythromycin lactobionate
3674
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 5 mg/ml
Injection Flucloxacillin sodium 20 mg/ml
Water for Injection 1232
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Production of gas bubbles Incompatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Foscarnet sodium 24 mg/ml
None 73
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 5 mg/ml
Injection Furosemide 1 mg/ml
Water for Injection 1232
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Promethazine hydrochloride
Injection Glycopyrronium bromide
3599
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Heparin sodium 1 UI/ml
Ringer’s lactate solution 1228
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Heparin sodium 1 UI/ml
NaCl 0,9% or Glucose 5% 1228
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Heparin sodium
3540
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
Ringer’s lactate solution 1228
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Ketamine hydrochloride 50 mg/ml
2109
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Ketorolac tromethamine 30 mg/ml
None 476
Immediate precipitation Incompatible
Injection Promethazine hydrochloride
Injection Ketorolac tromethamine
3593
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Promethazine hydrochloride 12.5 mg/ml
Injection Midazolam hydrochloride 2.5 mg/ml
None 404
Color change after 4 hours Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Promethazine hydrochloride 0.3 mg/ml
Injection Hydromorphone hydrochloride 1 mg/ml
Sodium chloride 0,9% 795
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Methotrexate sodium
3637
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Morphine sulfate
3531
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Nalbuphine hydrochloride 10 mg/ml
518
Compatible
Injection Promethazine hydrochloride 12,5 & 25 mg/ml
Injection Nalbuphine hydrochloride 5 & 10 mg/ml
616
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Nalbuphine hydrochloride
3672
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Promethazine hydrochloride 0.1 mg/ml
Injection Netilmicin sulfate 3 mg/ml
NaCl 0,9% or Glucose 5% 1200
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Palonosetron hydrochloride 50 µg/ml
None 2179
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Penicillin G sodium
3585
Immediate turbidity Incompatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 1228
Compatible
Injection Promethazine hydrochloride 50 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 1228
Compatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Ranitidine hydrochloride 25 mg/ml
None 58
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Immediate precipitation Incompatible
Injection Promethazine hydrochloride 25 mg/ml
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Unspecified incompatibility Incompatible
Injection Promethazine hydrochloride
Injection Thiopental sodium
3675
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Promethazine hydrochloride 2 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

  Mentions Légales