Last update :
18/04/2024
Anticancer drug   Mitoxantrone dihydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bluxantron Ecuador
Bresnix Mexico
Ebexantron Austria
Elsep France
Formyxan Colombia, Ecuador, Mexico
Genefadrone Greece
Mitoxgen Argentina
Neotalem Mexico
Novantron Austria, Germany, Switzerland
Novantrone Belgium, Chile, Denmark, France, Greece, Hungary, Ireland, Italy, Luxembourg, Malaysia, Morocco, New Zealand, Norway, Republic of South Africa, Romania, Slovenia, Spain, Sweden, Thailand, Turkey, United Arab Emirates, United States of America
Onkotrone Australia, Germany, Great Britain, Italy, Luxembourg, Romania
Ralenova Germany
Refador Hungary
Santrone Egypt, Malaysia
Strimax Spain
Xantrosin Belgium
Compatibility   Injection   Compatibility : Mitoxantrone dihydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate precipitation Incompatible
Injection Mitoxantrone dihydrochloride 0,5 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0,83 mg/ml
Glucose 5% 921
Precipitation after 1 hour Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Loss of turbidity Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Loss of turbidity Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Mitoxantrone dihydrochloride 0,05 & 1 mg/ml
Injection Etoposide 0,5 & 10 mg/ml
Sodium chloride 0,9% 1730
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Unspecified incompatibility Incompatible
Injection Mitoxantrone dihydrochloride
Injection Heparin sodium
3640
Immediate precipitation Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Mitoxantrone dihydrochloride 0,5 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Loss of turbidity Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 248
Immediate precipitation Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Immediate precipitation Incompatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Mitoxantrone dihydrochloride 0.5 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

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