Last update :
17/04/2024
References   References 300  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/11/1287

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF.
Title : Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 1287-1292. 1997

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Compatible 7 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAlfentanil hydrochloride Analgesic
Compatible 500 µg/ml + InjectionPropofol 10 mg/ml + None
InjectionAmikacin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAtracurium besylate Curarimimetic
Incompatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAtropine sulfate Antimuscarinic
Compatible 0.1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionBretylium tosilate Anti-arrhythmic
Incompatible 50 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCalcium chloride Electrolyte
Incompatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCeftazidime Antibiotic
Compatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCiclosporin Immunosuppressant
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCiprofloxacin lactate Antibiotic
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCisplatin Anticancer drug
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionCytarabine Anticancer drug
Compatible 50 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDigoxin Cardiotonic
Compatible 250 µg/ml + InjectionPropofol 10 mg/ml + None
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionEphedrine hydrochloride Sympathomimetic
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 100 µg/ml + InjectionPropofol 10 mg/ml + None
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionPropofol 10 mg/ml + None
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionFluorouracil Anticancer drug
Compatible 16 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionFurosemide Diuretic
Compatible 3 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionGanciclovir sodium Antiviral
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionGentamicin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionGlycopyrronium bromide Antimuscarinic
Compatible 0.2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionPropofol 10 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionIfosfamide Anticancer drug
Compatible 25 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionPropofol 10 mg/ml + None
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.004 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionKetamine hydrochloride General anesthetic
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMannitol Various
Compatible 150 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMethotrexate sodium Anticancer drug
Incompatible 15 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMinocycline hydrochloride Antibiotic
Incompatible 0.2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNetilmicin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.016 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionOfloxacin Antibiotic
Compatible 4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPancuronium bromide Curarimimetic
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPentobarbital sodium General anesthetic
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPhenobarbital sodium Antiepileptic
Compatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0.1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionPropofol 10 mg/ml + None
InjectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionPropofol General anesthetic
Compatible 10 mg/ml + InjectionAciclovir sodium 7 mg/ml + None
Compatible 10 mg/ml + InjectionAlfentanil hydrochloride 500 µg/ml + None
Incompatible 10 mg/ml + InjectionAmikacin sulfate 5 mg/ml + None
Compatible 10 mg/ml + InjectionAminophylline 2.5 mg/ml + None
Incompatible 10 mg/ml + InjectionAmphotericin B 0.6 mg/ml + None
Compatible 10 mg/ml + InjectionAmpicillin sodium 20 mg/ml + None
Incompatible 10 mg/ml + InjectionAtracurium besylate 10 mg/ml + None
Compatible 10 mg/ml + InjectionAtropine sulfate 0.1 mg/ml + None
Compatible 10 mg/ml + InjectionAztreonam 40 mg/ml + None
Incompatible 10 mg/ml + InjectionBretylium tosilate 50 mg/ml + None
Compatible 10 mg/ml + InjectionBumetanide 0.04 mg/ml + None
Compatible 10 mg/ml + InjectionBuprenorphine hydrochloride 0.04 mg/ml + None
Compatible 10 mg/ml + InjectionButorphanol tartrate 0.04 mg/ml + None
Incompatible 10 mg/ml + InjectionCalcium chloride 40 mg/ml + None
Compatible 10 mg/ml + InjectionCalcium gluconate 40 mg/ml + None
Compatible 10 mg/ml + InjectionCarboplatin 5 mg/ml + None
Compatible 10 mg/ml + InjectionCefazolin sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCefonicid sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCefoperazone sodium 40 mg/ml + None
Compatible 10 mg/ml + InjectionCefotaxime sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCefoxitin sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCeftazidime 40 mg/ml + None
Compatible 10 mg/ml + InjectionCeftizoxime sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCeftriaxone disodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionCefuroxime sodium 30 mg/ml + None
Compatible 10 mg/ml + InjectionChlorpromazine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionCiclosporin 5 mg/ml + None
Compatible 10 mg/ml + InjectionCimetidine hydrochloride 12 mg/ml + None
Compatible 10 mg/ml + InjectionCiprofloxacin lactate 1 mg/ml + None
Compatible 10 mg/ml + InjectionCisplatin 1 mg/ml + None
Compatible 10 mg/ml + InjectionClindamycin phosphate 10 mg/ml + None
Compatible 10 mg/ml + InjectionCyclophosphamide 10 mg/ml + None
Compatible 10 mg/ml + InjectionCytarabine 50 mg/ml + None
Compatible 10 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + None
Incompatible 10 mg/ml + InjectionDiazepam 5 mg/ml + None
Compatible 10 mg/ml + InjectionDigoxin 250 µg/ml + None
Compatible 10 mg/ml + InjectionDiphenhydramine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionDobutamine hydrochloride 4 mg/ml + None
Compatible 10 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + None
Compatible 10 mg/ml + InjectionDoxorubicin hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionDoxycycline hyclate 1 mg/ml + None
Compatible 10 mg/ml + InjectionDroperidol 0.4 mg/ml + None
Compatible 10 mg/ml + InjectionEnalaprilate 0.1 mg/ml + None
Compatible 10 mg/ml + InjectionEphedrine hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionEpinephrine hydrochloride 100 µg/ml + None
Compatible 10 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionFamotidine 2 mg/ml + None
Compatible 10 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Compatible 10 mg/ml + InjectionFluconazole 2 mg/ml + None
Compatible 10 mg/ml + InjectionFluorouracil 16 mg/ml + None
Compatible 10 mg/ml + InjectionFurosemide 3 mg/ml + None
Compatible 10 mg/ml + InjectionGanciclovir sodium 20 mg/ml + None
Incompatible 10 mg/ml + InjectionGentamicin sulfate 5 mg/ml + None
Compatible 10 mg/ml + InjectionGlycopyrronium bromide 0.2 mg/ml + None
Compatible 10 mg/ml + InjectionGranisetron hydrochloride 0.05 mg/ml + None
Compatible 10 mg/ml + InjectionHaloperidol lactate 0.2 mg/ml + None
Compatible 10 mg/ml + InjectionHeparin sodium 100 UI/ml + None
Compatible 10 mg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + None
Compatible 10 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + None
Compatible 10 mg/ml + InjectionHydroxyzine dihydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionIfosfamide 25 mg/ml + None
Compatible 10 mg/ml + InjectionImipenem - cilastatin sodium 10 mg/ml + None
Compatible 10 mg/ml + InjectionInsulin 1 UI/ml + None
Compatible 10 mg/ml + InjectionIsoprenaline hydrochloride 0.004 mg/ml + None
Compatible 10 mg/ml + InjectionKetamine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionLabetalol hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionLidocaine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionLorazepam 0.1 mg/ml + None
Compatible 10 mg/ml + InjectionMagnesium sulfate 100 mg/ml + None
Compatible 10 mg/ml + InjectionMannitol 150 mg/ml + None
Incompatible 10 mg/ml + InjectionMethotrexate sodium 15 mg/ml + None
Incompatible 10 mg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + None
Compatible 10 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionMidazolam hydrochloride 2 mg/ml + None
Incompatible 10 mg/ml + InjectionMinocycline hydrochloride 0.2 mg/ml + None
Incompatible 10 mg/ml + InjectionMitoxantrone dihydrochloride 0.5 mg/ml + None
Compatible 10 mg/ml + InjectionMorphine sulfate 1 mg/ml + None
Compatible 10 mg/ml + InjectionNafcillin sodium 20 mg/ml + None
Compatible 10 mg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
Incompatible 10 mg/ml + InjectionNetilmicin sulfate 5 mg/ml + None
Compatible 10 mg/ml + InjectionNitroglycerin 0.4 mg/ml + None
Compatible 10 mg/ml + InjectionNitroprusside sodium 0.4 mg/ml + None
Compatible 10 mg/ml + InjectionNorepinephrine bitartrate 0.016 mg/ml + None
Compatible 10 mg/ml + InjectionOfloxacin 4 mg/ml + None
Compatible 10 mg/ml + InjectionPaclitaxel 1.2 mg/ml + None
Compatible 10 mg/ml + InjectionPancuronium bromide 1 mg/ml + None
Compatible 10 mg/ml + InjectionPentobarbital sodium 5 mg/ml + None
Compatible 10 mg/ml + InjectionPethidine hydrochloride 4 mg/ml + None
Compatible 10 mg/ml + InjectionPhenobarbital sodium 5 mg/ml + None
Compatible 10 mg/ml + InjectionPhenylephrine hydrochloride 0.1 mg/ml + None
Incompatible 10 mg/ml + InjectionPhenytoin sodium 50 mg/ml + None
Compatible 10 mg/ml + InjectionPiperacillin sodium 40 mg/ml + None
Compatible 10 mg/ml + InjectionPotassium chloride 100 mEq/l + None
Compatible 10 mg/ml + InjectionProchlorperazine edysilate 0.5 mg/ml + None
Compatible 10 mg/ml + InjectionPropranolol hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + InjectionRanitidine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionScopolamine hydrobromide 0.4 mg/ml + None
Compatible 10 mg/ml + InjectionSodium bicarbonate 84 mg/ml + None
Compatible 10 mg/ml + InjectionSufentanil citrate 0.05 mg/ml + None
Compatible 10 mg/ml + InjectionSuxamethonium chloride 20 mg/ml + None
Compatible 10 mg/ml + InjectionTicarcillin / clavulanic acid 31 mg/ml + None
Incompatible 10 mg/ml + InjectionTobramycin sulfate 5 mg/ml + None
Compatible 10 mg/ml + InjectionVancomycin hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionVecuronium bromide 1 mg/ml + None
Compatible 10 mg/ml + InjectionVerapamil hydrochloride 2.5 mg/ml + None
InjectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionScopolamine hydrobromide Antimuscarinic
Compatible 0.4 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionSuxamethonium chloride Curarimimetic
Compatible 20 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionVecuronium bromide Curarimimetic
Compatible 1 mg/ml + InjectionPropofol 10 mg/ml + None
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2.5 mg/ml + InjectionPropofol 10 mg/ml + None

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