Last update :
11/08/2022
Local anesthetic   Lidocaine hydrochloride  
Injection
Mouthwash Ointments
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Jetokaine Turkey
Lidocard Finland
Lidocorit Austria
Lidosen Italy
Lidrian Italy
Linisol Belgium
Locaine Republic of South Africa
Minijet lignocaine Great Britain
Pisacaina Ecuador, Mexico
Plidocain Poland
Rapidocain Switzerland
Remicaine Republic of South Africa
Remicard Republic of South Africa
Xilina Romania
Xylanest Austria
Xylesine Switzerland
Xylestesin Brazil
Xylocain Austria, Canada, Denmark, Finland, Norway, Poland, Sweden, Switzerland
Xylocaina Brazil, Italy
Xylocaine Australia, Belgium, Canada, France, Greece, Luxembourg, Malaysia, Morocco, Netherlands, Slovenia, United States of America
Xylocard Belgium, Canada, Egypt, France, Portugal, Sweden
Xylocitin Germany
Xyloneural Austria, Switzerland
Compatibility   Injection   Compatibility : Lidocaine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Alteplase 0.5 mg/ml
Water for Injection 240
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Alteplase 1 mg/ml
Water for Injection 92
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Aminophylline 1 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Aminophylline 1 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Amiodarone hydrochloride 1.8 mg/ml
NaCl 0,9% or Glucose 5% 242
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Amiodarone hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1036
Immediate precipitation Incompatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Argatroban 1 mg/ml
Glucose 5% 1963
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Bretylium tosilate 1 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Bretylium tosilate 1 mg/ml
NaCl 0,9% or Glucose 5% 1193
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Bretylium tosilate 1 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Bretylium tosilate 10 mg/ml
NaCl 0,9% or Glucose 5% 705
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Calcium gluconate 2 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Calcium gluconate 2 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 5 >> 20 mg/ml
Injection Cefamandole nafate 285 mg/ml
NaCl 0,9% or Glucose 5% 612
Unspecified incompatibility Incompatible
Injection Lidocaine hydrochloride
Injection Cefamandole nafate
3546
Precipitation after 2 hours Incompatible
Injection Lidocaine hydrochloride
Injection Cefazolin sodium
499
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Unspecified incompatibility Incompatible
Injection Lidocaine hydrochloride
Injection Ceftobiprole medocaril sodium
4650
Immediate turbidity Incompatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Immediate precipitation Incompatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
Ringer’s lactate solution 2269
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Cefuroxime sodium
3687
Compatible
Injection Lidocaine hydrochloride 1.25 mg/ml
Injection Cimetidine hydrochloride 3 mg/ml
Glucose 5% 1201
Compatible
Injection Lidocaine hydrochloride 40 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
Glucose 5% 288
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 288
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
Injection Lidocaine hydrochloride 3,3 mg/ml
Injection Daptomycin 16,7 mg/ml
Sodium chloride 0,9% 1937
Compatible
Injection Lidocaine hydrochloride
Injection Daptomycin
2271
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Digoxin 1 µg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Digoxin 1 µg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Diltiazem hydrochloride 1 mg/ml
Glucose 5% 524
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Diltiazem hydrochloride 1 & 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Lidocaine hydrochloride 4 & 8 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Dobutamine hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 1058
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
Glucose 5% 738
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Enalaprilate 0.05 mg/ml
Sodium chloride 0,9% 1315
Compatible
Injection Lidocaine hydrochloride 9 & 18 mg/ml
Injection Epinephrine hydrochloride 9 µg/ml
NaHCO3 2878
Compatible
Injection Lidocaine hydrochloride
Injection Eptifibatide
3934
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Etomidate 2 mg/ml
None 319
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Famotidine
Glucose 5% 397
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Flucloxacillin sodium 20 mg/ml
Sodium chloride 0,9% 1232
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Flumazenil 0,02 mg/ml
Glucose 5% 187
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Furosemide 1 mg/ml
Sodium chloride 0,9% 1232
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Haloperidol lactate 0.5 & 5 mg/ml
Glucose 5% 403
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Heparin sodium 50 UI/ml
None 317
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Ringer’s lactate solution 4603
Compatible
Injection Lidocaine hydrochloride
Injection Hyaluronidase
3184
Chemical instability Incompatible
Injection Lidocaine hydrochloride
Injection Hydroxocobalamin
3932
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
Glucose 5% 4433
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Insulin 1 UI/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Insulin 1 UI/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Ketamine hydrochloride 2.5 mg/ml
Sodium chloride 0,9% 4350
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Labetalol hydrochloride 1 mg/ml
Glucose 5% 386
Immediate precipitation Incompatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Levofloxacine 5 mg/ml
Glucose 5% 1072
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Precipitation after 8 hours Incompatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Metoprolol tartrate 1 mg/ml
None 2346
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
Injection Lidocaine hydrochloride 5 & 10 mg/ml
Injection Moxalactam 333 mg/ml
None 626
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection N-acetylcysteine 200 mg/ml
None 3766
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Nicardipine hydrochloride 0.1 mg/ml
NaCl 0,9% or Glucose 5% 1490
Compatible
Injection Lidocaine hydrochloride 0.13 mg/ml
Parenteral nutrition (with lipids) 1338
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 62
Compatible
Injection Lidocaine hydrochloride 0,6 mg/ml
Injection Nafcillin sodium 20 mg/ml
NaCl 0,9% or Glucose 5% 278
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Nitroglycerin 0.4 mg/ml
NaCl 0,9% or Glucose 5% 1049
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Palonosetron hydrochloride 50 µg/ml
Glucose 5% 2279
Precipitation after 4 hours Incompatible
Injection Lidocaine hydrochloride
Injection Pantoprazole sodium
2090
Compatible
Injection Lidocaine hydrochloride 1 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 62
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Phenylephrine hydrochloride 2.5 mg/ml
None 1331
Immediate precipitation Incompatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Phenytoin sodium 1 mg/ml
NaCl 0,9% or Glucose 5% 619
Immediate precipitation Incompatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Phenytoin sodium 1 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 730
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 730
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Procainamide hydrochloride 1 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Procainamide hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Propafenone hydrochloride 1 mg/ml
Glucose 5% 925
Instability of the emulsion after 6 hours Incompatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Propofol
660
Compatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Propofol 2 mg/ml
None 319
Immediate instability of the emulsion Incompatible
Injection Lidocaine hydrochloride 1.8 mg/ml
Injection Propofol 9 mg/ml
None 794
Immediate instability of the emulsion Incompatible
Injection Lidocaine hydrochloride 1.3 mg/ml
Injection Propofol 8.7 mg/ml
None 794
Compatible
Injection Lidocaine hydrochloride 0.23 >> 0.95 mg/ml
Injection Propofol 9.5 mg/ml
None 794
Compatible
Injection Lidocaine hydrochloride 10 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Lidocaine hydrochloride 0,25 & 0,5 mg/ml
Injection Propofol 10 mg/ml
None 3502
Compatible
Injection Lidocaine hydrochloride 0,25 & 0,5 mg/ml
Injection Propofol 10 mg/ml
None 2053
Instability of the emulsion after 4 hours Incompatible
Injection Lidocaine hydrochloride 1 & 2 mg/ml
Injection Propofol 10 mg/ml
None 2053
Immediate instability of the emulsion Incompatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Propofol 8 mg/ml
None 794
Compatible
Injection Lidocaine hydrochloride 1 & 8 mg/ml
Injection Ranitidine hydrochloride 0.05 & 2 mg/ml
NaCl 0,9% or Glucose 5% 210
Compatible
Injection Lidocaine hydrochloride 1 & 8 mg/ml
Injection Ranitidine hydrochloride 0.05 & 2 mg/ml
NaCl 0,9% or Glucose 5% 214
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Streptokinase 30000 UI/ml
Glucose 5% 92
Compatible
Injection Lidocaine hydrochloride 8 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Theophylline 4 mg/ml
None 317
Immediate turbidity Incompatible
Injection Lidocaine hydrochloride 20 mg/ml
Injection Thiopental sodium 25 mg/ml
Water for Injection 319
Compatible
Injection Lidocaine hydrochloride
Injection Tigecycline
Sodium chloride 0,9% 3332
Compatible
Injection Lidocaine hydrochloride 1 & 20 mg/ml
Injection Tirofiban 50 µg/ml
NaCl 0,9% or Glucose 5% 1420
Compatible
Injection Lidocaine hydrochloride
Injection Tirofiban
1512
Compatible
Injection Lidocaine hydrochloride 4 mg/ml
Injection Vasopressin 2 & 4 UI/ml
Sodium chloride 0,9% 1801
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Verapamil hydrochloride 0,08 mg/ml
Sodium chloride 0,9% 706
Compatible
Injection Lidocaine hydrochloride 2 mg/ml
Injection Warfarin sodium 2 mg/ml
Glucose 5% 315

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