Last update :
22/01/2022
Analgesic   Buprenorphine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bunondol Poland
Buprenex United States of America
Buprex Spain
Temgesic Belgium, Denmark, France, Great Britain, Italy, Netherlands, Norway, Sweden, Tunisia, United Arab Emirates
Compatibility   Injection   Compatibility : Buprenorphine hydrochloride        
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Immediate precipitation Incompatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Loss of turbidity Incompatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Turbidity in 4 hours Incompatible
Injection Buprenorphine hydrochloride 0,075 mg/ml
Injection Furosemide 1 mg/ml
Water for Injection 1232
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Immediate precipitation Incompatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Buprenorphine hydrochloride 0.15 mg/ml
Injection Midazolam hydrochloride 2.5 mg/ml
None 404
Compatible
Injection Buprenorphine hydrochloride 0,04 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Buprenorphine hydrochloride 0.04 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

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