Last update :
15/10/2021
Sympathomimetic   Norepinephrine bitartrate  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Adine Chile
Biemefrin Turkey
Boguefren Mexico
Cardenor Turkey
Cardiamed Malaysia
Drenorep Peru
Epinor India
Fioritina Argentina
Hyponor Brazil
Levonor Poland
Levophed Belgium, Canada, Chile, Luxembourg, Malaysia, New Zealand, Saudi Arabia, United Arab Emirates, United States of America
Levophrine Egypt
Naretia Mexico
Nepridar Mexico
Noradren Peru
Noradrenalin Norway
Noradrenaline France, Great Britain, Ireland, Romania, Switzerland, Tunisia
Norages Spain
Norepine Belgium
Pridam Chile, Mexico
Radrenit Mexico
Softamicid Mexico
Steradine Turkey
Tehipren Mexico
Compatibility   Injection   Compatibility : Norepinephrine bitartrate        
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Precipitation after 4 hours Incompatible
Injection Norepinephrine bitartrate 0,5 mg/ml
Injection Alprostadil 20 µg/ml
Glucose 5% 4491
Compatible
Injection Norepinephrine bitartrate 0.96 mg/ml
Injection Amiodarone hydrochloride 15 mg/ml
NaCl 0,9% or Glucose 5% 3823
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Amiodarone hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1036
Immediate turbidity Incompatible
Injection Norepinephrine bitartrate 0,1 mg/ml
Injection Amiodarone hydrochloride 25 mg/ml
Glucose 5% 4119
Immediate turbidity Incompatible
Injection Norepinephrine bitartrate 0,2 mg/ml
Injection Amiodarone hydrochloride 25 mg/ml
Glucose 5% 4119
Immediate turbidity Incompatible
Injection Norepinephrine bitartrate 0,5 mg/ml
Injection Amiodarone hydrochloride 25 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,1 mg/ml
Injection Amiodarone hydrochloride 0,6 >> 9,75 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,2 mg/ml
Injection Amiodarone hydrochloride 0,6 >> 9,75 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,5 mg/ml
Injection Amiodarone hydrochloride 0,6 >> 9,75 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,5 mg/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,1 mg/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
Glucose 5% 4119
Compatible
Injection Norepinephrine bitartrate 0,2 mg/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
Glucose 5% 4119
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Amobarbital sodium
642
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Argatroban 1 mg/ml
Sodium chloride 0,9% 1964
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Parenteral nutrition (binary mixture) 3948
Compatible
Injection Norepinephrine bitartrate 0.016 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
NaHCO3 642
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Calcium gluconate
3644
Compatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Compatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Ceftobiprole 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Ceftobiprole 2 mg/ml
Ringer’s lactate solution 2269
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Chlorothiazide sodium
642
Compatible
Injection Norepinephrine bitartrate 0.04 mg/ml
Injection Cimetidine hydrochloride 3 mg/ml
Glucose 5% 1201
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
Glucose 5% 285
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Norepinephrine bitartrate 0,02 mg/ml
Injection Clonidine hydrochloride 0,018 mg/ml
Sodium chloride 0,9% 2018
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Parenteral nutrition (with lipids) 3948
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Diltiazem hydrochloride 1 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,12 mg/ml
Injection Diltiazem hydrochloride 1 mg/ml
Glucose 5% 524
Compatible
Injection Norepinephrine bitartrate 0,06 mg/ml
Injection Dobutamine hydrochloride 5 mg/ml
Glucose 5% 3177
Compatible
Injection Norepinephrine bitartrate 0.96 mg/ml
Injection Dobutamine hydrochloride 10 mg/ml
Glucose 5% 3823
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Compatible
Injection Norepinephrine bitartrate 0.06 mg/ml
Injection Dobutamine hydrochloride 5 mg/ml
Glucose 5% 3381
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Dobutamine hydrochloride 4 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.06 mg/ml
Injection Dobutamine hydrochloride 5 mg/ml
Glucose 5% 2879
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Dobutamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Dopamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0.96 mg/ml
Injection Dopamine hydrochloride 20 mg/ml
Glucose 5% 3823
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Dopamine hydrochloride 3.2 mg/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 0.06 mg/ml
Injection Dopamine hydrochloride 5 mg/ml
Glucose 5% 2879
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Epinephrine hydrochloride 20 µg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,032 mg/ml
Injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Esmolol hydrochloride 40 mg/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Ringer’s lactate solution 4603
Compatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
Injection Norepinephrine bitartrate 0.00027 mg/ml
Parenteral nutrition (with lipids) 1338
Compatible
Injection Norepinephrine bitartrate 0,06 mg/ml
Injection Dopamine hydrochloride 5 mg/ml
Glucose 5% 3177
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Dopamine hydrochloride 3.2 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Esmolol hydrochloride 10 mg/ml
Sodium chloride 0,9% 3879
Compatible
Injection Norepinephrine bitartrate 0.004 mg/ml
Injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Fentanyl citrate 30 µg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Fentanyl citrate 50 µg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Norepinephrine bitartrate 0,1 mg/ml
Injection Furosemide 1 mg/ml
Glucose 5% 4570
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Furosemide 10 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,016 mg/ml
Injection Furosemide 1 mg/ml
Sodium chloride 0,9% 4570
Compatible
Injection Norepinephrine bitartrate 0,016 mg/ml
Injection Furosemide 10 mg/ml
Sodium chloride 0,9% 4570
Compatible
Injection Norepinephrine bitartrate 0,1 mg/ml
Injection Furosemide 10 mg/ml
Glucose 5% 4570
Compatible
Injection Norepinephrine bitartrate 0.1 mg/ml
Injection Furosemide 10 mg/ml
None 3210
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Haloperidol lactate 0.5 & 5 mg/ml
Glucose 5% 403
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Heparin sodium 100 UI/ml
314
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
Sodium chloride 0,9% 4465
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Hydromorphone hydrochloride 1 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,032 mg/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Immediate precipitation Incompatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Insulin 1 UI/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Insulin 1 UI/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0,12 mg/ml
Injection Insulin aspart 1 UI/ml
NaCl 0,9% or Glucose 5% 1508
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Ketamine hydrochloride 50 mg/ml
4389
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Labetalol hydrochloride 5 mg/ml
Sodium chloride 0,9% 3879
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Labetalol hydrochloride 5 mg/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Labetalol hydrochloride 2 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,016 >>0,064 mg/ml
Injection Levetiracetam 5 mg/ml
Sodium chloride 0,9% 4569
Compatible
Injection Norepinephrine bitartrate 0,064 mg/ml
Injection Levofloxacine 5 mg/ml
Glucose 5% 3865
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Lorazepam 0.5 mg/ml
314
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Magnesium sulfate
3838
Compatible
Injection Norepinephrine bitartrate 8 mg/ml
Injection Meropenem 1 & 20 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Meropenem 1 & 50 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Methadone hydrochloride 0.2 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Metoprolol tartrate 0.4 mg/ml
Sodium chloride 0,9% 3879
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Midazolam hydrochloride 2 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Midazolam hydrochloride 1 mg/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Midazolam hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0,032 mg/ml
Injection Milrinone lactate 1 mg/ml
4506
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Milrinone lactate 0.8 mg/ml
Glucose 5% 813
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Milrinone lactate 0.2 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.32 mg/ml
Injection Morphine hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 295
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Morphine sulfate 2 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0,064 mg/ml
Injection Moxifloxacin 1,6 mg/ml
Glucose 5% 3865
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Mycophenolate mofetil 5,9 mg/ml
Glucose 5% 2192
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection N-acetylcysteine 200 mg/ml
None 3766
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Norepinephrine bitartrate 0.064 mg/ml
Injection Netilmicin sulfate 3 mg/ml
NaCl 0,9% or Glucose 5% 1200
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Nicardipine hydrochloride 1 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Nitroglycerin 0.4 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Compatible
Injection Norepinephrine bitartrate < 0.013 mg/ml
Injection Pantoprazole sodium < 0.8 mg/ml
Sodium chloride 0,9% 1902
Compatible
Injection Norepinephrine bitartrate < 0.064 mg/ml
Injection Pantoprazole sodium < 0.1 mg/ml
Sodium chloride 0,9% 1902
Immediate turbidity Incompatible
Injection Norepinephrine bitartrate > 0.064 mg/ml
Injection Pantoprazole sodium > 0.8 mg/ml
Sodium chloride 0,9% 1902
Precipitation after 15 minutes Incompatible
Injection Norepinephrine bitartrate
Injection Pantoprazole sodium
2090
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Pentobarbital sodium
642
Compatible
Injection Norepinephrine bitartrate 5 mg/ml
Injection Pentoxifyllin 5 mg/ml
Sodium chloride 0,9% 4543
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Phenobarbital sodium
642
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Phenytoin sodium
642
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Norepinephrine bitartrate
Injection Posaconazole
4380
Compatible
Injection Norepinephrine bitartrate 0.016 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Propofol
4524
Compatible
Injection Norepinephrine bitartrate 4 & 8 mg/ml
Injection Ranitidine hydrochloride 0.05 & 2 mg/ml
NaCl 0,9% or Glucose 5% 214
Compatible
Injection Norepinephrine bitartrate 0.004 & 0.008 mg/ml
Injection Ranitidine hydrochloride 0.05 & 2 mg/ml
NaCl 0,9% or Glucose 5% 210
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Ranitidine hydrochloride 1 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.12 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Sodium bicarbonate
642
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate
Injection Streptomycin sulfate
642
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Sufentanil citrate 0,05 mg/ml
4389
Compatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Sugammadex 100 mg/ml
None 3372
Compatible
Injection Norepinephrine bitartrate 0.032 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Ringer’s lactate solution 3254
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
NaCl 0,9% or Glucose 5% 3254
Immediate precipitation Incompatible
Injection Norepinephrine bitartrate 1 mg/ml
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Precipitation after 4 hours Incompatible
Injection Norepinephrine bitartrate 0,128 mg/ml
Injection Thiopental sodium 25 mg/ml
314
Unspecified incompatibility Incompatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Thiopental sodium 25 mg/ml
642
Compatible
Injection Norepinephrine bitartrate
Injection Tigecycline
Sodium chloride 0,9% 3332
Compatible
Injection Norepinephrine bitartrate 0.004 mg/ml
Injection Vasopressin 2 & 4 UI/ml
Sodium chloride 0,9% 1801
Compatible
Injection Norepinephrine bitartrate 0.004 & 0.016 mg/ml
Injection Vasopressin 0.2 UI/ml
Sodium chloride 0,9% 2017
Compatible
Injection Norepinephrine bitartrate 0.128 mg/ml
Injection Vecuronium bromide 1 mg/ml
314
Compatible
Injection Norepinephrine bitartrate 0.008 mg/ml
Injection Verapamil hydrochloride 0.08 mg/ml
NaCl 0,9% or Glucose 5% 1057

  Mentions Légales