Last update :
30/09/2022
Antiepileptic   Phenytoin sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aurantin Italy
Diphantoine Belgium, Netherlands
Epanutin Austria, Germany, Great Britain, Greece, Netherlands, Poland, Turkey
Hidantal Brazil
Phenhydan Switzerland
Compatibility   Injection   Compatibility : Phenytoin sodium              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Amikacin sulfate
3549
Chemical instability Incompatible
Injection Phenytoin sodium
Glucose 5% 1169
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0,83 mg/ml
Glucose 5% 921
Immediate precipitation Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Bretylium tosilate 1 mg/ml
NaCl 0,9% or Glucose 5% 1193
Compatible
Injection Phenytoin sodium 50 mg/ml
Injection Caffeine 10 mg/ml
None 3964
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Cefepime dihydrochloride 125 mg/ml
Water for Injection 2141
Immediate precipitation Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Ceftazidime 125 mg/ml
Water for Injection 2141
Immediate precipitation Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
Sodium chloride 0,9% 3828
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 288
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Clindamycin phosphate
3526
Precipitation after 1 hour Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Diltiazem hydrochloride 1 & 5 mg/ml
Sodium chloride 0,9% 198
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Immediate precipitation Incompatible
Injection Phenytoin sodium 1 mg/ml
Injection Dobutamine hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 1058
Immediate precipitation Incompatible
Injection Phenytoin sodium 1 mg/ml
Injection Enalaprilate 1.25 mg/ml
Sodium chloride 0,9% 201
Compatible
Injection Phenytoin sodium 2.5 mg/ml
Injection Enalaprilate 0.0125 mg/ml
Sodium chloride 0,9% 1703
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Erythromycin lactobionate
3674
Compatible
Injection Phenytoin sodium 1 mg/ml
Injection Esmolol hydrochloride 10 mg/ml
Glucose 5% 384
Compatible
Injection Phenytoin sodium 50 mg/ml
Injection Famotidine
Glucose 5% 397
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Precipitation after 1 hour Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Fentanyl citrate 25 µg/ml
Glucose 5% 1974
Compatible
Injection Phenytoin sodium 50 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Foscarnet sodium 24 mg/ml
None 73
Immediate turbidity Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Fosfomycin 30 mg/ml
Sodium chloride 0,9% 4055
Immediate precipitation Incompatible
Injection Phenytoin sodium
Glucose 5% 2074
Immediate precipitation Incompatible
Injection Phenytoin sodium
Injection Hydroxocobalamin
3932
Immediate turbidity Incompatible
Injection Phenytoin sodium 5 mg/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Immediate precipitation Incompatible
Injection Phenytoin sodium
Glucose 5% 3316
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Hyaluronidase
3617
Immediate precipitation Incompatible
Injection Phenytoin sodium
Glucose 5% 707
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Gentamicin sulfate 10 mg/ml
789
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Hyaluronidase
3184
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Hydromorphone hydrochloride 2 >> 40 mg/ml
Glucose 5% 226
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Ringer’s lactate solution 4603
Immediate precipitation Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Heparin sodium 50 UI/ml
None 317
Precipitation after 1 hour Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Hydromorphone hydrochloride 0.5 mg/ml
Glucose 5% 1974
Immediate precipitation Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
Sodium chloride 0,9% 3829
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Ketamine hydrochloride 50 mg/ml
2109
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Parenteral nutrition (binary mixture) 939
Precipitation after 4 hours Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Immediate precipitation Incompatible
Injection Phenytoin sodium 1 mg/ml
Injection Lidocaine hydrochloride 2 mg/ml
Ringer’s lactate solution 619
Immediate precipitation Incompatible
Injection Phenytoin sodium 1 mg/ml
Injection Lidocaine hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 619
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Linezolid
3560
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Phenytoin sodium 5 mg/ml
Injection Mannitol 200 mg/ml
Sodium chloride 0,9% 3315
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Immediate precipitation Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Methadone hydrochloride 1 mg/ml
Glucose 5% 1974
Turbidity in one hour Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Turbidity in 24 hours Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 1974
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Morphine sulfate
3531
Precipitation after 15 minutes Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Precipitation after 24 hours Incompatible
Injection Phenytoin sodium 1 mg/ml
Injection Nitroglycerin 0.4 mg/ml
NaCl 0,9% or Glucose 5% 1049
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Norepinephrine bitartrate
642
Immediate turbidity Incompatible
Injection Phenytoin sodium 6 mg/ml
Injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Precipitation after 1 hour Incompatible
Injection Phenytoin sodium
Injection Pantoprazole sodium
2090
Immediate precipitation Incompatible
Injection Phenytoin sodium 5 mg/ml
Injection Paracetamol
Sodium chloride 0,9% 3315
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Paracetamol 10 mg/ml
Glucose 5% 4435
Immediate turbidity Incompatible
Injection Phenytoin sodium
Injection Pethidine hydrochloride
3525
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Phenylephrine hydrochloride
3620
Immediate turbidity Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 730
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 730
Immediate instability of the emulsion Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Propofol
660
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Propofol 10 mg/ml
None 300
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Compatible
Injection Phenytoin sodium 50 mg/ml
Injection Sugammadex 100 mg/ml
None 3372
Turbidity in 24 hours Incompatible
Injection Phenytoin sodium 5 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Immediate turbidity Incompatible
Injection Phenytoin sodium 10 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Phenytoin sodium 50 mg/ml
Injection Temocilline 83.33 mg/ml
Water for Injection 2231
Immediate precipitation Incompatible
Injection Phenytoin sodium 2 mg/ml
Injection Theophylline 4 mg/ml
None 317
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Valproic acid 2 & 20 mg/ml
NaCl 0,9% or Glucose 5% 4428
Immediate precipitation Incompatible
Injection Phenytoin sodium 5 mg/ml
Injection Vancomycin hydrochloride 4 mg/ml
Sodium chloride 0,9% 3421
Unspecified incompatibility Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Unspecified incompatibility Incompatible
Injection Phenytoin sodium
Injection Vancomycin hydrochloride
3588
Immediate precipitation Incompatible
Injection Phenytoin sodium 50 mg/ml
Injection Vasopressin 0.2 UI/ml
Sodium chloride 0,9% 2017
Compatible
Injection Phenytoin sodium 0,5 mg/ml
Injection Verapamil hydrochloride 0,08 mg/ml
Sodium chloride 0,9% 706

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