Last update :
17/04/2024
References   References 1713  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=585

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Saenz CA.
Title : Compatibility screening of bivalirudin during simulated Y-site administration with other drugs.
Reference : Int J Pharm Compound ; 6: 311-315. 2002

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAlfentanil hydrochloride Analgesic
Compatible 125 µg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAlteplase Thrombolytic
Incompatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 4 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAzithromycine Antibiotic
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionBivalirudin Anticoagulant
Compatible 5 mg/ml + InjectionAlfentanil hydrochloride 125 µg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionAlteplase 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAminophylline 2.5 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionAmiodarone hydrochloride 4 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionAmphotericin B 0.6 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAmpicillin sodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAzithromycine 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionAztreonam 40 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionBretylium tosilate 50 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionBumetanide 0.04 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionButorphanol tartrate 0.04 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCalcium gluconate 40 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefazolin sodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefepime dihydrochloride 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefoperazone sodium 40 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefotaxime sodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefoxitin sodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCeftazidime 40 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCeftizoxime sodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCeftriaxone disodium 20 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCefuroxime sodium 30 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionChlorpromazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionClindamycin phosphate 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionCo-trimoxazole 4/0.8 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionDiazepam 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDigoxin 250 µg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDiltiazem hydrochloride 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDiphenhydramine hydrochloride 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDobutamine hydrochloride 4 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDoxycycline hyclate 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionDroperidol 2.5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionEnalaprilate 0.1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionEphedrine hydrochloride 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionEpinephrine hydrochloride 50 µg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionEptifibatide 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionErythromycin lactobionate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionFamotidine 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionFentanyl citrate 50 µg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionFluconazole 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionFurosemide 3 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionGentamicin sulfate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionHaloperidol lactate 0.2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionHeparin sodium 100 UI/ml + Glucose 5%
Compatible 5 mg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionIsoprenaline hydrochloride 0.02 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionLabetalol hydrochloride 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionLevofloxacine 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionLidocaine hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionLorazepam 0.5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMagnesium sulfate 100 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMannitol 150 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMetronidazole 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMilrinone lactate 0.2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMorphine sulfate 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionNitroglycerin 0.4 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionNitroprusside sodium 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionNorepinephrine bitartrate 0.12 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionOfloxacin 4 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPethidine hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPhenylephrine hydrochloride 1 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPiperacillin sodium 40 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPotassium chloride 100 mEq/l + Glucose 5%
Compatible 5 mg/ml + InjectionProcainamide hydrochloride 10 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionProchlorperazine edysilate 0.5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionPromethazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionRanitidine hydrochloride 2 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionReteplase 1 UI/ml + Glucose 5%
Compatible 5 mg/ml + InjectionSodium bicarbonate 84 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionStreptokinase 30000 UI/ml + Glucose 5%
Compatible 5 mg/ml + InjectionSufentanil citrate 0.05 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionTheophylline 4 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionThiopental sodium 25 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionTicarcillin / clavulanic acid 31 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionTirofiban 50 µg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionTobramycin sulfate 5 mg/ml + Glucose 5%
Incompatible 5 mg/ml + InjectionVancomycin hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionVerapamil hydrochloride 1.25 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionWarfarin sodium 2 mg/ml + Glucose 5%
InjectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefepime dihydrochloride Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCeftazidime Antibiotic
Compatible 40 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionChlorpromazine hydrochloride Anxiolytic
Incompatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionCo-trimoxazole Antibiotic
Compatible 4/0.8 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDigoxin Cardiotonic
Compatible 250 µg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionDroperidol Neuroleptic
Compatible 2.5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionEphedrine hydrochloride Sympathomimetic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 50 µg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionEptifibatide Anticoagulant
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionErythromycin lactobionate Antibiotic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionFurosemide Diuretic
Compatible 3 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.02 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionLabetalol hydrochloride Beta-blocker
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionLevofloxacine Antibiotic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionLorazepam Anxiolytic
Compatible 0.5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMannitol Various
Compatible 150 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMilrinone lactate Cardiotonic
Compatible 0.2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionNitroprusside sodium Vasodilator
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.12 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionOfloxacin Antibiotic
Compatible 4 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPethidine hydrochloride Analgesic
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPhenylephrine hydrochloride Sympathomimetic
Compatible 1 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionProchlorperazine edysilate Neuroleptic
Incompatible 0.5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionReteplase Thrombolytic
Incompatible 1 UI/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionStreptokinase Thrombolytic
Incompatible 30000 UI/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionTheophylline Various
Compatible 4 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionThiopental sodium General anesthetic
Compatible 25 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionTirofiban Anticoagulant
Compatible 50 µg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 10 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 1.25 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%
InjectionWarfarin sodium Anticoagulant
Compatible 2 mg/ml + InjectionBivalirudin 5 mg/ml + Glucose 5%

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