Last update :
09/04/2024
Antibiotic   Cefepime dihydrochloride  
Injection
Eye-drops
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aspime Venezuela
Avipim Turkey
Axépim France
Baxypime Mexico
Cachepime India
Cefalospim Brazil
Cefemin Colombia
Cefepem Brazil
Cefepitax Brazil
Cepim Italy
Cepimex Italy
Forcetex Egypt
Maxcef Brazil
Maxipime Austria, Belgium, Canada, Colombia, Finland, Germany, Greece, Hungary, Italy, Luxembourg, Peru, Poland, Portugal, Spain, Sweden, Turkey, United States of America
Nebamix Peru
Olpelinol Mexico
Pimcef Peru
Pimerzen Mexico
Roxipime Turkey
Unisef Turkey
Vipefime Mexico
Compatibility   Injection   Compatibility : Cefepime dihydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
Injection Cefepime dihydrochloride
Injection Amikacin sulfate
3549
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Amikacin sulfate 6 mg/ml
NaCl 0,9% or Glucose 5% 3548
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Amikacin sulfate 15 mg/ml
Water for Injection 2141
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Aminophylline
3548
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Ampicillin sodium 1 mg/ml
Glucose 5% 3548
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Ampicillin sodium 10 mg/ml
Sodium chloride 0,9% 3548
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Ampicillin sodium 1 mg/ml
Sodium chloride 0,9% 3548
Compatible
Injection Cefepime dihydrochloride 4 mg/ml
Injection Ampicillin sodium 40 mg/ml
Sodium chloride 0,9% 3548
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Ampicillin sodium 10 mg/ml
Glucose 5% 3548
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Color change after 1 hour Incompatible
Injection Cefepime dihydrochloride 100 mg/ml
Parenteral nutrition (with lipids) 3948
Color change after 1 hour Incompatible
Injection Cefepime dihydrochloride 100 mg/ml
Parenteral nutrition (binary mixture) 3948
Compatible
Injection Cefepime dihydrochloride 4 & 40 mg/ml
Injection Clindamycin phosphate 0,25 & 6 mg/ml
NaCl 0,9% or Glucose 5% 3548
Compatible
Injection Cefepime dihydrochloride 83.3 mg/ml
Injection Daptomycin 21 mg/ml
NaCl 0,9% or Glucose 5% 4254
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Dobutamine hydrochloride 1 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 10 mg/ml
Parenteral nutrition (with lipids) 4440
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Dopamine hydrochloride 0.4 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Erythromycin lactobionate
3674
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Esmolol hydrochloride 10 mg/ml
Sodium chloride 0,9% 3879
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Fluconazole 2 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Ringer’s lactate solution 4411
Chemical instability Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Erythromycin lactobionate 5 mg/ml
Water for Injection 2141
Immediate turbidity Incompatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Furosemide 10 mg/ml
Water for Injection 2141
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Gentamicin sulfate
3520
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Gentamicin sulfate
3643
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Gentamicin sulfate
3548
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Gentamicin sulfate 6 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Compatible
Injection Cefepime dihydrochloride 4 mg/ml
Injection Heparin sodium 10 & 50 UI/ml
NaCl 0,9% or Glucose 5% 3548
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
Sodium chloride 0,9% 4465
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Insulin 100 UI/ml
Water for Injection 2141
Immediate turbidity Incompatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Isosorbide dinitrate 0.2 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Ketamine hydrochloride 10 mg/ml
Water for Injection 2141
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Labetalol hydrochloride 5 mg/ml
Sodium chloride 0,9% 3879
Turbidity in 4 hours Incompatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Metoprolol tartrate 0.4 mg/ml
Sodium chloride 0,9% 3879
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Metronidazole
3548
Chemical instability Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Midazolam hydrochloride 5 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Mycophenolate mofetil 5,9 mg/ml
Glucose 5% 2192
Chemical instability Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection N-acetylcysteine 100 mg/ml
Water for Injection 2141
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Netilmicin sulfate
3548
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Nicardipine hydrochloride 1 mg/ml
Water for Injection 2141
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Phenytoin sodium 50 mg/ml
Water for Injection 2141
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Piritramide 2 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Compatible
Injection Cefepime dihydrochloride 4 mg/ml
Injection Potassium chloride 10 & 40 mEq/l
NaCl 0,9% or Glucose 5% 3548
Immediate precipitation Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Propofol 1 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Remifentanil hydrochloride 200 µg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 10 mg/ml
Injection Sodium citrate 40 mg/ml
None 3416
Compatible
Injection Cefepime dihydrochloride 5 mg/ml
Injection Sodium citrate 40 mg/ml
None 3416
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Sufentanil citrate 0.005 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
NaCl 0,9% or Glucose 5% 3254
Compatible
Injection Cefepime dihydrochloride 40 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
Ringer’s lactate solution 3254
Chemical instability Incompatible
Injection Cefepime dihydrochloride 200 mg/ml
Injection Temocilline 83.33 mg/ml
Water for Injection 2231
Compatible
Injection Cefepime dihydrochloride 4 mg/ml
Injection Theophylline 0,8 mg/ml
Glucose 5% 3548
Chemical instability Incompatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Theophylline 20 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 83.3 mg/ml
Injection Thiamine hydrochloride 0.2 mg/ml
NaCl 0,9% or Glucose 5% 4254
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Tobramycin sulfate
3548
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Tobramycin sulfate 6 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Urapidil 5 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Valproic acid 100 mg/ml
Water for Injection 2141
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride 200 mg/ml
Injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Compatible
Injection Cefepime dihydrochloride 83.33 mg/ml
Injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Unspecified incompatibility Incompatible
Injection Cefepime dihydrochloride
Injection Vancomycin hydrochloride
3548
Compatible
Injection Cefepime dihydrochloride 125 mg/ml
Injection Vancomycin hydrochloride 30 mg/ml
Water for Injection 2141
Compatible
Injection Cefepime dihydrochloride 20 mg/ml
Injection Vancomycin hydrochloride 4 mg/ml
Sodium chloride 0,9% 3542
Compatible
Injection Cefepime dihydrochloride 83.3 mg/ml
Injection Voriconazole 8 mg/ml
Glucose 5% 4254

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