Last update :
30/05/2024
References   References 81  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/5/672

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Martinez JF.
Title : Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 51: 672-678. 1994

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 7 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionBleomycin sulfate Anticancer drug
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCarmustine Anticancer drug
Compatible 1.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionChlorpromazine hydrochloride Anxiolytic
Incompatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCisplatin Anticancer drug
Incompatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionCytarabine Anticancer drug
Compatible 50 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDacarbazine Anticancer drug
Incompatible 4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDaunorubicin hydrochloride Anticancer drug
Incompatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDoxorubicin hydrochloride Anticancer drug
Incompatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDoxycycline hyclate Antibiotic
Incompatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionDroperidol Neuroleptic
Incompatible 0.4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFamotidine Antihistamine (H2)
Incompatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFloxuridine Anticancer drug
Compatible 3 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFludarabine phosphate Anticancer drug
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFluorouracil Anticancer drug
Compatible 16 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionFurosemide Diuretic
Compatible 3 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionGanciclovir sodium Antiviral
Incompatible 20 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionHaloperidol lactate Neuroleptic
Incompatible 0.2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionIdarubicin hydrochloride Anticancer drug
Incompatible 0.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionIfosfamide Anticancer drug
Compatible 25 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMannitol Various
Compatible 150 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMesna Cytoprotective
Compatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMinocycline hydrochloride Antibiotic
Incompatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMitomycin Anticancer drug
Incompatible 0.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionPiperacillin sodium / tazobactam Antibiotic
Incompatible 40/5 mg/ml + InjectionAciclovir sodium 7 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionAminophylline 2.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionAmphotericin B 0.6 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionAztreonam 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionBleomycin sulfate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionBumetanide 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionBuprenorphine hydrochloride 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionButorphanol tartrate 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCalcium gluconate 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCarboplatin 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCarmustine 1.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionChlorpromazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionCisplatin 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionClindamycin phosphate 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCo-trimoxazole 0.8/4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCyclophosphamide 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionCytarabine 50 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDacarbazine 4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDaunorubicin hydrochloride 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionDiphenhydramine hydrochloride 2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDobutamine hydrochloride 4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDoxorubicin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDoxycycline hyclate 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionDroperidol 0.4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionEnalaprilate 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionEtoposide 0.4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionFamotidine 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFloxuridine 3 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFluconazole 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFludarabine phosphate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFluorouracil 16 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFolinate calcium 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionFurosemide 3 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionGallium nitrate 0.4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionGanciclovir sodium 20 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionHaloperidol lactate 0.2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionHeparin sodium 100 UI/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionHydroxyzine dihydrochloride 4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionIdarubicin hydrochloride 0.5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionIfosfamide 25 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionLorazepam 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMagnesium sulfate 100 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMannitol 150 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMesna 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMethotrexate sodium 15 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMetronidazole 5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionMinocycline hydrochloride 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionMitomycin 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionMitoxantrone dihydrochloride 0.5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionMorphine sulfate 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionOndansetron hydrochloride 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionPethidine hydrochloride 4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionPotassium chloride 100 mEq/l + Glucose 5%
Incompatible 40/5 mg/ml + InjectionProchlorperazine edysilate 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionPromethazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionRanitidine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionSargramostim 10 µg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionSodium bicarbonate 84 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionStreptozocin 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionThiotepa 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + InjectionVancomycin hydrochloride 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionVinblastine sulfate 0.12 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionVincristine sulfate 0.05 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + InjectionZidovudine 4 mg/ml + Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionProchlorperazine edysilate Neuroleptic
Incompatible 0.5 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionPromethazine hydrochloride Antihistamine (H1)
Incompatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionSargramostim Various
Compatible 10 µg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionStreptozocin Anticancer drug
Incompatible 40 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionThiotepa Anticancer drug
Compatible 1 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
InjectionZidovudine Antiviral
Compatible 4 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%

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