Last update :
18/04/2024
Cytoprotective   Folinate calcium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Antrex Finland
Axifolin Germany
Bendafolin Egypt, Iran
Biofolic Italy
Calcium leucovorin Turkey
Calfolex Italy
Citofolin Italy
Cromaton Luxembourg
Dalisol Colombia, India, Mexico
Degalin Germany
Durofolin Greece
Etamolin Peru
Eurofolic Germany
Fastovorin India
Folcasin Romania
Folical Colombia
Folidan Spain
Folinate de calcium France
Furoic Italy
Innefol Mexico
Lederfolin Great Britain, Ireland, Italy
Ledervorin calcium Australia, Belgium, Colombia, Ireland, Luxembourg, Poland, Saudi Arabia, United Arab Emirates
Leucocalcin Argentina, Chile
Leucovorin Austria, Belgium, Germany, Great Britain, Greece, Hungary, Poland, Slovenia, Switzerland, Turkey
Neofolin Germany
Novizet Argentina
Precileucin Mexico
Prefolic Italy
Refolinon Great Britain, Greece
Rescuvolin Belgium, Colombia, Germany, Greece, Luxembourg, Malaysia, Netherlands, Republic of South Africa, Sweden
Ribofolin Austria, Germany, Iran
Rontafor Argentina
Sanficinate Greece
Sanifolin Italy
Tecnovorin Colombia, Peru
Veravorin Greece
Xanacanto Mexico
Compatibility   Injection   Compatibility : Folinate calcium              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Precipitation after 30 minutes Incompatible
Injection Folinate calcium 10 mg/ml
NaHCO3 150
Chemical instability Incompatible
Injection Folinate calcium
Injection Bleomycin sulfate
4154
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Cefamandole nafate
3546
Immediate precipitation Incompatible
Injection Folinate calcium
Injection Ceftriaxone disodium
3523
Compatible
Injection Folinate calcium 2 mg/ml
Injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
Injection Folinate calcium 2 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
Injection Folinate calcium 2 mg/ml
Parenteral nutrition (with lipids) 1415
Immediate precipitation Incompatible
Injection Folinate calcium 2 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Folinate calcium 2 mg/ml
Injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
Injection Folinate calcium 2 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Folinate calcium 2 mg/ml
Injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
Injection Folinate calcium 2 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Compatible
Injection Folinate calcium 10 mg/ml
Injection Doxorubicin hydrochloride 2 mg/ml
763
Compatible
Injection Folinate calcium 2 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
Injection Folinate calcium 10 mg/ml
Injection Droperidol 2,5 mg/ml
763
Compatible
Injection Folinate calcium 2 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Folinate calcium 2 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
Injection Folinate calcium 0.03 >> 0.960 mg/ml
Injection Floxuridine 1 >> 4 mg/ml
Sodium chloride 0,9% 3694
Compatible
Injection Folinate calcium 10 mg/ml
Injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 496
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Fluorouracil
3474
Precipitation after 24 hours Incompatible
Injection Folinate calcium 1.54 >> 13.33 mg/ml
Injection Fluorouracil 16.67 >> 46.15 mg/ml
None 155
Compatible
Injection Folinate calcium 10 mg/ml
Injection Fluorouracil 50 mg/ml
763
Precipitation after 24 hours Incompatible
Injection Folinate calcium 1.54 >> 13.33 mg/ml
Injection Fluorouracil 16.67 >> 46.15 mg/ml
Glucose 5% 155
Compatible
Injection Folinate calcium 30.8 mg/ml
Injection Fluorouracil 6.5 mg/ml
2130
Precipitation after 24 hours Incompatible
Injection Folinate calcium 30.8 mg/ml
Injection Fluorouracil 50 mg/ml
NaCl 0,9% or Glucose 5% 2181
Compatible
Injection Folinate calcium 4 mg/ml
Injection Fluorouracil 6.5 mg/ml
NaCl 0,9% or Glucose 5% 2181
Immediate precipitation Incompatible
Injection Folinate calcium 30.8 mg/ml
Injection Fluorouracil 50 mg/ml
2130
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Fosaprepitant dimeglumine
2295
Immediate turbidity Incompatible
Injection Folinate calcium 10 mg/ml
Injection Foscarnet sodium 24 mg/ml
None 73
Compatible
Injection Folinate calcium 10 mg/ml
Injection Furosemide 10 mg/ml
763
Compatible
Injection Folinate calcium 2 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Folinate calcium 2 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Compatible
Injection Folinate calcium 10 mg/ml
Injection Heparin sodium 1000 UI/ml
763
Compatible
Injection Folinate calcium 0.27 >> 0.94 mg/ml
Injection Irinotecan 0.30 >> 0.59 mg/ml
Glucose 5% 2027
Chemical instability Incompatible
Injection Folinate calcium 3.6 mg/ml
Injection Irinotecan 0.32 mg/ml
Glucose 5% 2027
Compatible
Injection Folinate calcium 0,23 >> 0,95 mg/ml
Injection Irinotecan 0,31 >> 0,65 mg/ml
Glucose 5% 2340
Chemical instability Incompatible
Injection Folinate calcium 3,55 >> 3,67 mg/ml
Injection Irinotecan 0,34 >> 0,35 mg/ml
Glucose 5% 2340
Immediate precipitation Incompatible
Injection Folinate calcium 2 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Folinate calcium 2 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Magnesium sulfate
3838
Compatible
Injection Folinate calcium 10 mg/ml
Injection Methotrexate sodium 30 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Folinate calcium 10 mg/ml
Injection Methotrexate sodium 25 mg/ml
763
Compatible
Injection Folinate calcium 10 mg/ml
Injection Metoclopramide hydrochloride 5 mg/ml
763
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Omadacycline
4720
Compatible
Injection Folinate calcium
Injection Oxaliplatin
3634
Compatible
Injection Folinate calcium 2 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Pamidronate disodium
3619
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Pemetrexed disodium
1914
Compatible
Injection Folinate calcium 2 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Folinate calcium 2 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Potassium phosphate
3621
Precipitation after 30 minutes Incompatible
Injection Folinate calcium 10 mg/ml
Injection Sodium bicarbonate 14 mg/ml
None 150
Compatible
Injection Folinate calcium 10 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Tedizolid phosphate
3753
Compatible
Injection Folinate calcium 2 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Folinate calcium 2 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Folinate calcium 10 mg/ml
Injection Vinblastine sulfate 1 mg/ml
763
Compatible
Injection Folinate calcium 10 mg/ml
Injection Vincristine sulfate 1 mg/ml
763
Unspecified incompatibility Incompatible
Injection Folinate calcium
Injection Zoledronic acid
3933

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