Last update :
17/04/2024
References   References 3964  
Type : Journal
Web link : http://www.pharmactuel.com/index.php/pharmactuel/article/view/1129

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Audet M.A, Forest E, Friciu M, Forest J.M, Leclair G.
Title : Compatibilité du citrate de caféine injectable avec plusieurs autres médicaments.
Reference : Pharmactuel ; 50,1 : 27-33. 2017

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAmphotericin B liposomale Antifungal
Compatible 4 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAmpicillin sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionAzithromycine Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionBenztropine mesylate Antimuscarinic
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionBupivacaine hydrochloride Local anesthetic
Compatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCaffeine Respiratory stimulant
Compatible 10 mg/ml + InjectionAciclovir sodium 50 mg/ml + None
Compatible 10 mg/ml + InjectionAmikacin sulfate 250 mg/ml + None
Incompatible 10 mg/ml + InjectionAmiodarone hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionAmphotericin B liposomale 4 mg/ml + None
Compatible 10 mg/ml + InjectionAmpicillin sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionAtropine sulfate 0.4 mg/ml + None
Compatible 10 mg/ml + InjectionAzithromycine 100 mg/ml + None
Compatible 10 mg/ml + InjectionBenztropine mesylate 1 mg/ml + None
Compatible 10 mg/ml + InjectionBretylium tosilate 50 mg/ml + None
Compatible 10 mg/ml + InjectionBupivacaine hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionCalcium chloride 100 mg/ml + None
Compatible 10 mg/ml + InjectionCalcium gluconate 100 mg/ml + None
Incompatible 10 mg/ml + InjectionCaspofungin acetate 5 mg/ml + None
Compatible 10 mg/ml + InjectionCefazolin sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCefotaxime sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCefoxitin sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCeftazidime 100 mg/ml + None
Compatible 10 mg/ml + InjectionCeftriaxone disodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCefuroxime sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionChlorpromazine hydrochloride 25 mg/ml + None
Incompatible 10 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + None
Compatible 10 mg/ml + InjectionClindamycin phosphate 150 mg/ml + None
Compatible 10 mg/ml + InjectionCloxacillin sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCo-trimoxazole 16/80 mg/ml + None
Compatible 10 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + None
Compatible 10 mg/ml + InjectionDexmedetomidine 100 µg/ml + None
Incompatible 10 mg/ml + InjectionDiazepam 5 mg/ml + None
Compatible 10 mg/ml + InjectionDigoxin 250 µg/ml + None
Compatible 10 mg/ml + InjectionDimenhydrinate 10 mg/ml + None
Compatible 10 mg/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + None
Incompatible 10 mg/ml + InjectionDipyridamol 5 mg/ml + None
Incompatible 10 mg/ml + InjectionDobutamine hydrochloride 12.5 mg/ml + None
Incompatible 10 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + None
Incompatible 10 mg/ml + InjectionDroperidol 2.5 mg/ml + None
Compatible 10 mg/ml + InjectionEpinephrine hydrochloride 100 µg/ml + None
Incompatible 10 mg/ml + InjectionErythromycin lactobionate 50 mg/ml + None
Compatible 10 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Compatible 10 mg/ml + InjectionFluconazole 2 mg/ml + None
Compatible 10 mg/ml + InjectionFurosemide 10 mg/ml + None
Compatible 10 mg/ml + InjectionGentamicin sulfate 10 mg/ml + None
Compatible 10 mg/ml + InjectionGranisetron hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + InjectionHeparin sodium 1000 UI/ml + None
Compatible 10 mg/ml + InjectionHuman albumin 250 mg/ml + None
Compatible 10 mg/ml + InjectionHydralazine hydrochloride 20 mg/ml + None
Compatible 10 mg/ml + InjectionHydrocortisone sodium succinate 250 mg/ml + None
Compatible 10 mg/ml + InjectionHydromorphone hydrochloride 50 mg/ml + None
Incompatible 10 mg/ml + InjectionHydroxyzine dihydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionInsulin 100 UI/ml + None
Incompatible 10 mg/ml + InjectionIsoprenaline hydrochloride 0.2 mg/ml + None
Compatible 10 mg/ml + InjectionKetamine hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionLabetalol hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionLevofloxacine 5 mg/ml + None
Compatible 10 mg/ml + InjectionLidocaine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionLinezolid 2 mg/ml + None
Incompatible 10 mg/ml + InjectionLorazepam 4 mg/ml + None
Compatible 10 mg/ml + InjectionMagnesium sulfate 500 mg/ml + None
Compatible 10 mg/ml + InjectionMannitol 250 mg/ml + None
Compatible 10 mg/ml + InjectionMeropenem 50 mg/ml + None
Compatible 10 mg/ml + InjectionMethylprednisolone sodium succinate 500 mg/ml + None
Compatible 10 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionMetronidazole 5 mg/ml + None
Incompatible 10 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionMilrinone lactate 1 mg/ml + None
Compatible 10 mg/ml + InjectionMorphine sulfate 50 mg/ml + None
Compatible 10 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
Incompatible 10 mg/ml + InjectionNitroglycerin 5 mg/ml + None
Compatible 10 mg/ml + InjectionNitroprusside sodium 25 mg/ml + None
Compatible 10 mg/ml + InjectionNorepinephrine bitartrate 1 mg/ml + None
Compatible 10 mg/ml + InjectionOndansetron hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionOxytocin 10 UI/ml + None
Compatible 10 mg/ml + InjectionPantoprazole sodium 40 mg/ml + None
Compatible 10 mg/ml + InjectionPenicillin G sodium 0.5 MUI/ml + None
Compatible 10 mg/ml + InjectionPhenytoin sodium 50 mg/ml + None
Compatible 10 mg/ml + InjectionPiperacillin sodium 200 mg/ml + None
Compatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 200 mg/ml + None
Compatible 10 mg/ml + InjectionPotassium chloride 200 mEq/l + None
Incompatible 10 mg/ml + InjectionPotassium phosphate 4.4 mmol/ml + None
Compatible 10 mg/ml + InjectionProcainamide hydrochloride 100 mg/ml + None
Compatible 10 mg/ml + InjectionPromethazine hydrochloride 25 mg/ml + None
Compatible 10 mg/ml + InjectionPropranolol hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + InjectionRanitidine hydrochloride 25 mg/ml + None
Compatible 10 mg/ml + InjectionRocuronium bromide 10 mg/ml + None
Compatible 10 mg/ml + InjectionSalbutamol sulfate 1 mg/ml + None
Compatible 10 mg/ml + InjectionSodium bicarbonate 84 mg/ml + None
Incompatible 10 mg/ml + InjectionSodium Phosphate 3 mmol/ml + None
Compatible 10 mg/ml + InjectionSufentanil citrate 0.05 mg/ml + None
Compatible 10 mg/ml + InjectionTicarcillin / clavulanic acid 200 mg/ml + None
Compatible 10 mg/ml + InjectionTobramycin sulfate 40 mg/ml + None
Incompatible 10 mg/ml + InjectionVancomycin hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionVoriconazole 10 mg/ml + None
InjectionCalcium chloride Electrolyte
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCaspofungin acetate Antifungal
Incompatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCefazolin sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCeftazidime Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 25 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCloxacillin sodium Antibiotic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionCo-trimoxazole Antibiotic
Compatible 16/80 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDigoxin Cardiotonic
Compatible 250 µg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDipyridamol Vasodilator
Incompatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 12.5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDopamine hydrochloride Cardiotonic
Incompatible 3.2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionDroperidol Neuroleptic
Incompatible 2.5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 100 µg/ml + InjectionCaffeine 10 mg/ml + None
InjectionErythromycin lactobionate Antibiotic
Incompatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionCaffeine 10 mg/ml + None
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionFurosemide Diuretic
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionGentamicin sulfate Antibiotic
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + InjectionCaffeine 10 mg/ml + None
InjectionHuman albumin Various
Compatible 250 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionHydralazine hydrochloride Antihypertensive
Compatible 20 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 250 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionInsulin Glucose-lowering
Compatible 100 UI/ml + InjectionCaffeine 10 mg/ml + None
InjectionIsoprenaline hydrochloride Beta-stimulant
Incompatible 0.2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionKetamine hydrochloride General anesthetic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionLevofloxacine Antibiotic
Compatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionLinezolid Antibiotic
Compatible 2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionLorazepam Anxiolytic
Incompatible 4 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMannitol Various
Compatible 250 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMeropenem Antibiotic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 500 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Incompatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionMorphine sulfate Analgesic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionN-acetylcysteine Antidote
Compatible 200 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionNitroprusside sodium Vasodilator
Compatible 25 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionOxytocin Various
Compatible 10 UI/ml + InjectionCaffeine 10 mg/ml + None
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 40 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPenicillin G sodium Antibiotic
Compatible 0.5 MUI/ml + InjectionCaffeine 10 mg/ml + None
InjectionPhenytoin sodium Antiepileptic
Compatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPotassium chloride Electrolyte
Compatible 200 mEq/l + InjectionCaffeine 10 mg/ml + None
InjectionPotassium phosphate Electrolyte
Incompatible 4.4 mmol/ml + InjectionCaffeine 10 mg/ml + None
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 100 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 25 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionSodium Phosphate Electrolyte
Incompatible 3 mmol/ml + InjectionCaffeine 10 mg/ml + None
InjectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 200 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionVancomycin hydrochloride Antibiotic
Incompatible 50 mg/ml + InjectionCaffeine 10 mg/ml + None
InjectionVoriconazole Antifungal
Compatible 10 mg/ml + InjectionCaffeine 10 mg/ml + None

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