Last update :
15/04/2024
References   References 1953  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/61/21/2289

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Title : Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 61: 2289-2293. 2004

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Compatible 7 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAmifostine Cytoprotective
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCalcium gluconate Electrolyte
Incompatible 40 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Incompatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCefotaxime sodium Antibiotic
Incompatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCefoxitin sodium Antibiotic
Incompatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Incompatible 40 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCisplatin Anticancer drug
Compatible 0.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionCytarabine Anticancer drug
Compatible 50 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDexrazoxane hydrochloride Cytoprotective
Compatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 4 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDocetaxel Anticancer drug
Compatible 0.8 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDoxorubicin hydrochloride Anticancer drug
Incompatible 1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDoxycycline hyclate Antibiotic
Incompatible 1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionDroperidol Neuroleptic
Incompatible 2.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionFluorouracil Anticancer drug
Compatible 16 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionGanciclovir sodium Antiviral
Compatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionGemcitabine hydrochloride Anticancer drug
Incompatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionGentamicin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml
InjectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionIfosfamide Anticancer drug
Compatible 20 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionIrinotecan Anticancer drug
Incompatible 1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionLorazepam Anxiolytic
Compatible 0.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMannitol Various
Compatible 150 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMesna Cytoprotective
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMinocycline hydrochloride Antibiotic
Incompatible 0.2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionMorphine sulfate Analgesic
Compatible 15 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionOndansetron hydrochloride Antiemetic
Incompatible 1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionPaclitaxel Anticancer drug
Compatible 0.6 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionPemetrexed disodium Anticancer drug
Compatible 20 mg/ml + InjectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAmifostine 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionAztreonam 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionBumetanide 0.04 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionBuprenorphine hydrochloride 0.04 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionButorphanol tartrate 0.04 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCalcium gluconate 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCarboplatin 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCefoxitin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCefuroxime sodium 30 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCimetidine hydrochloride 12 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCisplatin 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionClindamycin phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCyclophosphamide 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionCytarabine 50 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionDexrazoxane hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionDiphenhydramine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionDobutamine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionDocetaxel 0.8 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionDoxorubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionDoxycycline hyclate 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionDroperidol 2.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionEnalaprilate 0.1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionFluorouracil 16 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionFolinate calcium 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionGanciclovir sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionGemcitabine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionGentamicin sulfate 5 mg/ml
Compatible 20 mg/ml + InjectionGranisetron hydrochloride 0.05 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionHeparin sodium 100 UI/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionHydroxyzine dihydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionIfosfamide 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionIrinotecan 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionLorazepam 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionMannitol 150 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionMesna 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionMinocycline hydrochloride 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionMitoxantrone dihydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionMorphine sulfate 15 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionOndansetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionPaclitaxel 0.6 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionPethidine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionPotassium chloride 100 mEq/l + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionProchlorperazine edysilate 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionPromethazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionTicarcillin / clavulanic acid 31 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionTopotecan 0.1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionVancomycin hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionVinblastine sulfate 0.12 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionVincristine sulfate 0.05 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + InjectionZidovudine 4 mg/ml + Sodium chloride 0,9%
InjectionPethidine hydrochloride Analgesic
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionProchlorperazine edysilate Neuroleptic
Incompatible 0.5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionTopotecan Anticancer drug
Incompatible 0.1 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
InjectionZidovudine Antiviral
Compatible 4 mg/ml + InjectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%

  Mentions Légales