Last update :
07/10/2024
References   References 3571  
Type : Journal
Web link : 10.1310/hpj4901-42

Research teams : Salt Lake City - Primary children\'s hospital, department of Pharmacy
Authors : Anderson C, Boehme S, Ouellette J, Stidham C, MacKay M.
Title : Physical and Chemical Compatibility of Injectable Acetaminophen During Simulated Y-Site Administration.
Reference : Hosp Pharm ; 49, 1: 42-47. 2014

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 5 mg/ml + injectionParacetamol 10 mg/ml + None
injectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + injectionParacetamol 10 mg/ml + None
injectionCeftriaxone disodium Antibiotic
Compatible 40 mg/ml + injectionParacetamol 10 mg/ml + None
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionParacetamol 10 mg/ml + None
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionParacetamol 10 mg/ml + None
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionParacetamol 10 mg/ml + None
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + injectionParacetamol 10 mg/ml + None
injectionDolasetron mesylate Antiemetic
Compatible 20 mg/ml + injectionParacetamol 10 mg/ml + None
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionParacetamol 10 mg/ml + None
injectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + injectionParacetamol 10 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 125 mg/ml + injectionParacetamol 10 mg/ml + None
injectionHydromorphone hydrochloride Analgesic
Compatible 2 mg/ml + injectionParacetamol 10 mg/ml + None
injectionKetorolac tromethamine Anti-inflammatory
Compatible 30 mg/ml + injectionParacetamol 10 mg/ml + None
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 62.5 mg/ml + injectionParacetamol 10 mg/ml + None
injectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + injectionParacetamol 10 mg/ml + None
injectionMorphine sulfate Analgesic
Compatible 15 mg/ml + injectionParacetamol 10 mg/ml + None
injectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + injectionParacetamol 10 mg/ml + None
injectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + injectionParacetamol 10 mg/ml + None
injectionParacetamol Analgesic
Incompatible 10 mg/ml + injectionAciclovir sodium 5 mg/ml + None
Compatible 10 mg/ml + injectionCefoxitin sodium 100 mg/ml + None
Compatible 10 mg/ml + injectionCeftriaxone disodium 40 mg/ml + None
Compatible 10 mg/ml + injectionClindamycin phosphate 10 mg/ml + None
Compatible 10 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + None
Incompatible 10 mg/ml + injectionDiazepam 5 mg/ml + None
Compatible 10 mg/ml + injectionDiphenhydramine hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + injectionDolasetron mesylate 20 mg/ml + None
Compatible 10 mg/ml + injectionFentanyl citrate 50 µg/ml + None
Compatible 10 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + injectionHydrocortisone sodium succinate 125 mg/ml + None
Compatible 10 mg/ml + injectionHydromorphone hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionKetorolac tromethamine 30 mg/ml + None
Compatible 10 mg/ml + injectionMethylprednisolone sodium succinate 62.5 mg/ml + None
Compatible 10 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + injectionMorphine sulfate 15 mg/ml + None
Compatible 10 mg/ml + injectionNalbuphine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionOndansetron hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionPethidine hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 100 mg/ml + None
Compatible 10 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + None
injectionPethidine hydrochloride Analgesic
Compatible 50 mg/ml + injectionParacetamol 10 mg/ml + None
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 100 mg/ml + injectionParacetamol 10 mg/ml + None
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + injectionParacetamol 10 mg/ml + None
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionParacetamol 10 mg/ml + None
Stability of mixtures
Polypropylen Syringe Water for Injection 25°C Not specified
injection Diphenhydramine hydrochloride 50 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Granisetron hydrochloride 1 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Ketorolac tromethamine 30 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Nalbuphine hydrochloride 10 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Ondansetron hydrochloride 2 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Vancomycin hydrochloride 5 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Piperacillin sodium / tazobactam 90/10 mg/ml
injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
injection Ceftriaxone disodium 40 mg/ml
injection Paracetamol 10 mg/ml
4 Hour

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