Last update :
07/10/2024
References   References 4698  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Ayari G, D'Huart E, Vigneron J, Demoré B.
Title : Y-site compatibility of intravenous medications commonly used in intensive care units : laboratory tests on 75 mixtures involving nine main drugs.
Reference : Pharmaceutical Technology in Hospital Pharmacy 2022

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAcetylsalicylic acid lysinate Analgesic
Compatible 10 mg/ml + injectionHydrocortisone sodium succinate 2 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionMagnesium sulfate 6 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionNefopam 0,08 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionPhytomenadione 0,2 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionPotassium chloride 1340 mEq/l + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 3 mg/ml + injectionBumetanide 0,2 mg/ml + Glucose 5%
Incompatible 3 mg/ml + injectionCefazolin sodium 40 mg/ml + Glucose 5%
Compatible 9 mg/ml + injectionCefotaxime sodium 40 mg/ml + Glucose 5%
Incompatible 18 mg/ml + injectionFurosemide 5 mg/ml + Glucose 5%
Compatible 9 mg/ml + injectionHydrocortisone sodium succinate 2 mg/ml + Glucose 5%
Compatible 6 mg/ml + injectionInsulin 1 UI/ml + Glucose 5%
Compatible 3 mg/ml + injectionLevofloxacine 5 mg/ml + Glucose 5%
Compatible 9 mg/ml + injectionMagnesium sulfate 1,5 mg/ml + Glucose 5%
Compatible 9 mg/ml + injectionNefopam 0,16 mg/ml + Glucose 5%
Compatible 18 mg/ml + injectionParacetamol 10 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionPotassium chloride 1340 mEq/l + Glucose 5%
Compatible 3 mg/ml + injectionThiamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 9 mg/ml + injectionVancomycin hydrochloride 31,3 mg/ml + Glucose 5%
injectionAtenolol Beta-blocker
Incompatible 0,1 mg/ml + injectionCiclosporin 10 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + injectionMethylprednisolone sodium succinate 0,2 mg/ml + Sodium chloride 0,9%
Incompatible 0,1 mg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 0,1 mg/ml + injectionMycophenolate mofetil 10 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + injectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + injectionUrapidil 5 mg/ml + Sodium chloride 0,9%
injectionBumetanide Diuretic
Compatible 0,2 mg/ml + injectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
injectionCalcium chloride Electrolyte
Compatible 2 mg/ml + injectionNefopam 0,8 mg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Incompatible 40 mg/ml + injectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
injectionCefotaxime sodium Antibiotic
Compatible 40 mg/ml + injectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Incompatible 40 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionCiclosporin Immunosuppressant
Incompatible 10 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
injectionClonidine hydrochloride Antihypertensive
Incompatible 0,0125 mg/ml + injectionMethylprednisolone sodium succinate 0,2 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + injectionMycophenolate mofetil 10 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + injectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + injectionUrapidil 5 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 5 mg/ml + injectionAmiodarone hydrochloride 18 mg/ml + Glucose 5%
Incompatible 10 mg/ml + injectionMagnesium sulfate 6 mg/ml
Incompatible 10 mg/ml + injectionNefopam 1,7 mg/ml
Compatible 10 mg/ml + injectionParacetamol 10 mg/ml
Incompatible 10 mg/ml + injectionSpiramycine adipate 60 MUI/ml
injectionHeparin sodium Anticoagulant
Incompatible 208,3 UI/ml + injectionLevetiracetam 15 mg/ml + Sodium chloride 0,9%
Incompatible 208,3 UI/ml + injectionMidazolam hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 208,3 UI/ml + injectionNefopam 1,7 mg/ml + Sodium chloride 0,9%
Compatible 208,3 UI/ml + injectionParacetamol 10 mg/ml + Sodium chloride 0,9%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 2 mg/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + injectionAmiodarone hydrochloride 6 mg/ml + Glucose 5%
Compatible 1 UI/ml + injectionIsosorbide dinitrate 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 1 UI/ml + injectionPantoprazole sodium 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + injectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + injectionPhloroglucinol 10 mg/ml + Sodium chloride 0,9%
Incompatible 1 UI/ml + injectionRemifentanil hydrochloride 100 µg/ml + Sodium chloride 0,9%
injectionIsosorbide dinitrate Vasodilator
Compatible 1 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionLevetiracetam Antiepileptic
Incompatible 15 mg/ml + injectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
injectionLevofloxacine Antibiotic
Compatible 5 mg/ml + injectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 6 mg/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1,5 mg/ml + injectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Incompatible 6 mg/ml + injectionFurosemide 10 mg/ml
Compatible 3>>4,5 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0,2 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Incompatible 0,2 mg/ml + injectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
injectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Incompatible 1 mg/ml + injectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
injectionMycophenolate mofetil Immunosuppressant
Incompatible 10 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
injectionNefopam Analgesic
Compatible 0,08 mg/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Compatible 0,8 mg/ml + injectionCalcium chloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 0,16 mg/ml + injectionCefotaxime sodium 40 mg/ml + Sodium chloride 0,9%
Incompatible 1,7 mg/ml + injectionFurosemide 10 mg/ml
Incompatible 1,7 mg/ml + injectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionHydrocortisone sodium succinate 2 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionIsosorbide dinitrate 1 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionMagnesium sulfate 3>>4,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionNicardipine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionPyridoxine hydrochloride 0,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionThiamine hydrochloride 0,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + injectionTramadol hydrochloride 6,3 mg/ml + Sodium chloride 0,9%
injectionNicardipine hydrochloride Vasodilator
Compatible 1 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionPantoprazole sodium Proton pump inhibitor
Incompatible 1 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionPhloroglucinol 0,4 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionPhytomenadione 0,2 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionPyridoxine hydrochloride 0,0025 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionParacetamol Analgesic
Compatible 10 mg/ml + injectionAmiodarone hydrochloride 18 mg/ml + Glucose 5%
Compatible 10 mg/ml + injectionFurosemide 10 mg/ml
Compatible 10 mg/ml + injectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + injectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
injectionPhloroglucinol  Antispasmodic
Compatible 10 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 0,4 mg/ml + injectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
injectionPhytomenadione Vitamin
Compatible 0,2 mg/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Incompatible 0,2 mg/ml + injectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 1340 mEq/l + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1340 mEq/l + injectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
injectionPyridoxine hydrochloride Vitamin
Compatible 0,5 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 0,0025 mg/ml + injectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
injectionRemifentanil hydrochloride Analgesic
Incompatible 100 µg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
injectionSpiramycine adipate Antibiotic
Incompatible 60 MUI/ml + injectionFurosemide 10 mg/ml
injectionThiamine hydrochloride Vitamin
Compatible 1 mg/ml + injectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
Compatible 0,5 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
injectionTramadol hydrochloride Analgesic
Compatible 6,3 mg/ml + injectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
injectionUrapidil Antihypertensive
Compatible 5 mg/ml + injectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Compatible 31,3 mg/ml + injectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%

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