Last update :
08/12/2024
References   References 215  
Type : Journal
Web link : https://doi.org/10.1177/106002809302700404

Research teams : Quebec - Université Laval, Ecole de Pharmacie
Authors : Keyi X, Gagnon N, Bisson C, Desmarais M, LeBel M.
Title : Stability of famotidine in polyvinyl chloride minibags and polypropylene syringes and compatibility of famotidine with selected drugs.
Reference : Ann Pharmacotherapy ; 27: 422-426. 1993

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionAciclovir sodium Antiviral
Compatible 7 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionAmphotericin B Antifungal
Compatible 0.6 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionCefuroxime sodium Antibiotic
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionDobutamine hydrochloride Cardiotonic
Compatible 40 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionFamotidine Antihistamine (H2)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,2 mg/ml 22°C With or without light
15 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,2 mg/ml 22°C With or without light
15 Day
Compatible 2 mg/ml + injectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCefoxitin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCeftazidime 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionCefuroxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionChlorpromazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDiphenhydramine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDobutamine hydrochloride 40 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDopamine hydrochloride 1.6 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDroperidol 0.4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Incompatible 2 mg/ml + injectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionHeparin sodium 40 UI/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionHydroxyzine dihydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMidazolam hydrochloride 1.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionPethidine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionPiperacillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionPotassium chloride 13.4 mEq/l + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 3 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 40 UI/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 4 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Compatible 1.5 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 13.4 mEq/l + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%

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