Last update :
17/04/2024
References   References 215  
Type : Journal
Web link : https://doi.org/10.1177/106002809302700404

Research teams : Quebec - Université Laval, Ecole de Pharmacie
Authors : Keyi X, Gagnon N, Bisson C, Desmarais M, LeBel M.
Title : Stability of famotidine in polyvinyl chloride minibags and polypropylene syringes and compatibility of famotidine with selected drugs.
Reference : Ann Pharmacotherapy ; 27: 422-426. 1993

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Compatible 7 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionAminophylline Various
Compatible 2.5 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionAmphotericin B Antifungal
Compatible 0.6 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionCefuroxime sodium Antibiotic
Compatible 20 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 40 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionFamotidine Antihistamine (H2)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,2 mg/ml 22°C With or without light
15 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,2 mg/ml 22°C With or without light
15 Day
Compatible 2 mg/ml + InjectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCefoxitin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCeftazidime 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionCefuroxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionChlorpromazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDiphenhydramine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDobutamine hydrochloride 40 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDopamine hydrochloride 1.6 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionDroperidol 0.4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Incompatible 2 mg/ml + InjectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionHeparin sodium 40 UI/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionHydroxyzine dihydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionLorazepam 0.1 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMidazolam hydrochloride 1.5 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionPethidine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionPiperacillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionPotassium chloride 13.4 mEq/l + Sodium chloride 0,9%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Incompatible 3 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 40 UI/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 4 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 1.5 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 13.4 mEq/l + InjectionFamotidine 2 mg/ml + Sodium chloride 0,9%

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