Last update :
28/02/2024
References   References 1069  
Type : Journal

Research teams : Buies Creek - Campbell University, School of Pharmacy
Authors : Peek BT, Webster KD, Da Camara CC.
Title : Stability and compatibility of promethazine hydrochloride and dihydroergotamine mesylate in combination.
Reference : Am J Health-Syst Pharm ; 56: 1835-1838. 1999

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionDihydroergotamine mesilate Various
Compatible 0,5 mg/ml + InjectionPromethazine hydrochloride 12,5 & 25 mg/ml + None
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 12,5 & 25 mg/ml + InjectionDihydroergotamine mesilate 0,5 mg/ml + None
Stability of mixtures
Polypropylene None 25°C Protect from light
Injection Dihydroergotamine mesilate 0,5 mg/ml
Injection Promethazine hydrochloride 12,5 & 25 mg/ml
24 Hour
Polypropylene None 4°C Protect from light
Injection Dihydroergotamine mesilate 0,5 mg/ml
Injection Promethazine hydrochloride 12,5 & 25 mg/ml
24 Hour

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