Last update :
28/02/2024
References   References 2179  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2530

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trusley C, Ben M, Kupiec TC, Trissel LA.
Title : Physical and chemical stability of palonosetron with metoclopramide and promethazine during simulated Y-site administration.
Reference : Int J Pharm Compound ; 11, 1: 82-85. 2007

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 50 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + None
InjectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + InjectionMetoclopramide hydrochloride 50 mg/ml + None
Compatible 50 µg/ml + InjectionPromethazine hydrochloride 2 mg/ml + None
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + None
Stability of mixtures
Glass Glucose 5% 25°C Not specified
Injection Palonosetron hydrochloride 25 µg/ml
Injection Promethazine hydrochloride 1 mg/ml
4 Hour
Glass None 25°C Not specified
Injection Palonosetron hydrochloride 25 µg/ml
Injection Metoclopramide hydrochloride 25 mg/ml
4 Hour

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