Last update :
01/07/2022
References   References 4434  
Type : Journal
Web link : https://doi.org/10.1016/j.clinthera.2019.08.005

Research teams : Hartford - Center for Anti-Infective Research and Development
Authors : Avery L.M, Chen, I.H, Reyes, S, Nicolau, D.P, Kuti J.L.
Title : Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site Administration.
Reference : Clin Ther ; 41, 10: 2162-2170. 2019

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 2 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionAztreonam Antibiotic
Compatible 20 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionBumetanide Diuretic
Compatible 0,25 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCalcium chloride Electrolyte
Compatible 20 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCalcium gluconate Electrolyte
Compatible 20 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCefepime dihydrochloride Antibiotic
Compatible 40 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCeftaroline fosamil Antibiotic
Incompatible 12 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Compatible 40 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Avibactam Antibiotic
Compatible 40/10 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCeftolozane / tazobactam Antibiotic
Compatible 20/10 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionCisatracurium besylate Curarimimetic
Compatible 0,4 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionColistin mesilate sodium Antibiotic
Incompatible 4,5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionDexmedetomidine Sympathomimetic
Compatible 4 µg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4,1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionDopamine hydrochloride Cardiotonic
Compatible 0,8 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 16 µg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionEravacycline Antibiotic
Compatible 0,6 mg/ml + Ringer’s lactate solution
Incompatible 0,6 mg/ml + InjectionAmiodarone hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionAztreonam 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionBumetanide 0,25 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCalcium chloride 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCalcium gluconate 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCefepime dihydrochloride 40 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionCeftaroline fosamil 12 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCeftazidime Avibactam 40/10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCeftolozane / tazobactam 20/10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionCisatracurium besylate 0,4 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionColistin mesilate sodium 4,5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionDexmedetomidine 4 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionDiltiazem hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionDobutamine hydrochloride 4,1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionDopamine hydrochloride 0,8 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionEpinephrine hydrochloride 16 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionFentanyl citrate 50 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionHeparin sodium 1000 UI/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + Glucose 5%
Incompatible 0,6 mg/ml + InjectionHuman albumin 250 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionHydromorphone hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionImipenem - cilastatin sodium 5/5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionLevofloxacine 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionLinezolid 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionMeropenem 20 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionMeropenem Vaborbactam 8/8 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionMicafungin 4 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionMidazolam hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionNicardipine hydrochloride 0,1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionNorepinephrine bitartrate 0,032 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionOctreotide acetate 0,004 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionPantoprazole sodium 0,4 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionPhenylephrine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionPiperacillin sodium / tazobactam 40/5 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionPropofol 10 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + InjectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionVasopressin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + InjectionVecuronium bromide 1 mg/ml + Sodium chloride 0,9%
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Incompatible 3 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionHuman albumin Various
Incompatible 250 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionHydromorphone hydrochloride Analgesic
Compatible 1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionImipenem - cilastatin sodium Antibiotic
Compatible 5/5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionLevofloxacine Antibiotic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionLinezolid Antibiotic
Compatible 2 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMeropenem Antibiotic
Incompatible 20 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMeropenem Vaborbactam Antibiotic
Incompatible 8/8 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMicafungin Antifungal
Incompatible 4 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionNicardipine hydrochloride Vasodilator
Compatible 0,1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,032 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionOctreotide acetate Various
Compatible 0,004 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 0,4 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionPhenylephrine hydrochloride Sympathomimetic
Compatible 1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionPropofol General anesthetic
Incompatible 10 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionVasopressin Hormone
Compatible 1 UI/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
InjectionVecuronium bromide Curarimimetic
Compatible 1 mg/ml + InjectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%

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