Last update :
16/06/2024
References   References 1508  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2014-000478

Research teams : Lausanne - University Hospital, Department of Pharmacy
Authors : Voirol P, Berger-Gryllaki M, Pannatier A, Eggimann P, Sadeghipour F.
Title : Visual compatibility of insulin aspart with intravenous drugs frequently used in ICU.
Reference : EJHP ;22:123-124. 2015

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 6 & 12 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionCeftazidime Antibiotic
Compatible 20 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionCeftriaxone disodium Antibiotic
Compatible 10 & 50 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionCiclosporin Immunosuppressant
Compatible 1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionClonazepam Antiepileptic
Compatible 0,04 & 1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionClonidine hydrochloride Antihypertensive
Compatible 0,0125 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionDihydralazine mesilate Vasodilator
Compatible 0,05 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 60 & 300 µg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionEsomeprazole sodium Proton pump inhibitor
Incompatible 1 mg/ml + InjectionInsulin aspart 1 UI/ml + Glucose 5%
Compatible 1 mg/ml + InjectionInsulin aspart 1 UI/ml + Sodium chloride 0,9%
InjectionFentanyl citrate Analgesic
Compatible 5, 25 & 50 µg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionFurosemide Diuretic
Compatible 1 & 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 50 & 400 UI/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin aspart Glucose-lowering
Compatible 1 UI/ml + InjectionAmiodarone hydrochloride 6 & 12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionCeftazidime 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionCeftriaxone disodium 10 & 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionCiclosporin 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionClonazepam 0,04 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionClonidine hydrochloride 0,0125 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDihydralazine mesilate 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDiltiazem hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDobutamine hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionDopamine hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionEpinephrine hydrochloride 60 & 300 µg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + InjectionEsomeprazole sodium 1 mg/ml + Glucose 5%
Compatible 1 UI/ml + InjectionEsomeprazole sodium 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + InjectionFentanyl citrate 5, 25 & 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionFurosemide 1 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionHeparin sodium 50 & 400 UI/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + InjectionImipenem - cilastatin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionIsoprenaline hydrochloride 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionLabetalol hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionLevetiracetam 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMagnesium sulfate 20 & 100 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + InjectionMeropenem 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMidazolam hydrochloride 1 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMilrinone lactate 0,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNifedipine 0,1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNimodipine 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNitroglycerin 0,5 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNitroprusside sodium 1,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionNorepinephrine bitartrate 0,12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionOctreotide acetate 0,01 & 0,02 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + InjectionPantoprazole sodium 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionPiperacillin sodium / tazobactam 45 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionPotassium chloride 1 & 2 mEq/l + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionPropofol 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionRemifentanil hydrochloride 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionSalbutamol sulfate 0,1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionSodium thiosulfate 100 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionSufentanil citrate 0,005, 0,025 & 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionValproic acid 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionVancomycin hydrochloride 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionVasopressin 0,5 & 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionVerapamil hydrochloride 1,25 mg/ml + NaCl 0,9% or Glucose 5%
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0,05 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionLevetiracetam Antiepileptic
Compatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 20 & 100 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionMeropenem Antibiotic
Incompatible 20 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 1 & 5 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionMilrinone lactate Cardiotonic
Compatible 0,25 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionNifedipine Vasodilator
Compatible 0,1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionNimodipine Antihypertensive
Compatible 0,2 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 0,5 & 1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionNitroprusside sodium Vasodilator
Compatible 1,25 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,12 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionOctreotide acetate Various
Compatible 0,01 & 0,02 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionPantoprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 45 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 1 & 2 mEq/l + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionPropofol General anesthetic
Compatible 10 & 20 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionRemifentanil hydrochloride Analgesic
Compatible 100 µg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionSalbutamol sulfate Beta-stimulant
Compatible 0,1 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionSodium thiosulfate Antidote
Compatible 100 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionSufentanil citrate Analgesic
Compatible 0,005, 0,025 & 0,05 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionTirofiban Anticoagulant
Compatible 50 µg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionValproic acid Antiepileptic
Compatible 50 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionVasopressin Hormone
Compatible 0,5 & 1 UI/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 1,25 mg/ml + InjectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%

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