Last update :
08/06/2023
References   References 4389  
Type : Journal

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Côté K, Correal F, Metras M.E, Friciu M, Forest J.M, Leclair G.
Title : Compatibilité physique des médicaments administrés en Y aux soins intensifs, en particulier la dexmédétomidine, le lévosimendan et la kétamine.
Reference : Pharmactuel ;52,4:206-213 2019

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAcetazolamide Diuretic
Compatible 100 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionAlprostadil Vasodilator
Compatible 500 µg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 500 µg/ml + InjectionKetamine hydrochloride 50 mg/ml
Compatible 500 µg/ml + InjectionMilrinone lactate 1 mg/ml
InjectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + InjectionMeropenem 50 mg/ml
InjectionAminophylline Various
Incompatible 25 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionAmpicillin sodium Antibiotic
Compatible 100 mg/ml + InjectionPotassium chloride 2 mEq/l
InjectionAztreonam Antibiotic
Compatible 100 mg/ml + InjectionMeropenem 50 mg/ml
InjectionBenztropine mesylate Antimuscarinic
Compatible 1 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionCaffeine citrate Respiratory stimulant
Compatible 10 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionCefoxitin sodium Antibiotic
Incompatible 100 mg/ml + InjectionImipenem - cilastatin sodium 50 mg/ml
InjectionCeftazidime Antibiotic
Compatible 100 mg/ml + InjectionMeropenem 50 mg/ml
InjectionCiclosporin Immunosuppressant
Compatible 50 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionCloxacillin sodium Antibiotic
Compatible 100 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + InjectionAcetazolamide 100 mg/ml
Compatible 100 µg/ml + InjectionAlprostadil 500 µg/ml
Compatible 100 µg/ml + InjectionBenztropine mesylate 1 mg/ml
Compatible 100 µg/ml + InjectionCaffeine citrate 10 mg/ml
Compatible 100 µg/ml + InjectionCloxacillin sodium 100 mg/ml
Compatible 100 µg/ml + InjectionDimenhydrinate 10 mg/ml
Compatible 100 µg/ml + InjectionHuman albumin 250 mg/ml
Compatible 100 µg/ml + InjectionHydralazine hydrochloride 20 mg/ml
Compatible 100 µg/ml + InjectionKetamine hydrochloride 50 mg/ml
Compatible 100 µg/ml + InjectionLevosimendan 2.5 mg/ml
Incompatible 100 µg/ml + InjectionMicafungin 20 mg/ml
Compatible 100 µg/ml + InjectionMilrinone lactate 1 mg/ml
Compatible 100 µg/ml + InjectionN-acetylcysteine 200 mg/ml
Compatible 100 µg/ml + InjectionPenicillin G sodium 0,5 MUI/ml
Compatible 100 µg/ml + InjectionPhentolamine mesylate 5 mg/ml
Compatible 100 µg/ml + InjectionSalbutamol sulfate 1 mg/ml
Compatible 100 µg/ml + InjectionThiamine hydrochloride 100 mg/ml
Compatible 100 µg/ml + InjectionTranexamic acid 100 mg/ml
Compatible 100 µg/ml + InjectionValproic acid 100 mg/ml
InjectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 10 mg/ml + InjectionPotassium chloride 2 mEq/l
InjectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + InjectionFurosemide 10 mg/ml
Compatible 3,2 mg/ml + InjectionHeparin sodium 100 UI/ml
Incompatible 3,2 mg/ml + InjectionInsulin 100 UI/ml
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
Compatible 10 mg/ml + InjectionMilrinone lactate 1 mg/ml
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionHeparin sodium 100 UI/ml
Compatible 50 µg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionFurosemide Diuretic
Compatible 10 mg/ml + InjectionDopamine hydrochloride 3,2 mg/ml
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionDopamine hydrochloride 3,2 mg/ml
Compatible 100 UI/ml + InjectionFentanyl citrate 50 µg/ml
Compatible 100 UI/ml + InjectionLevosimendan 2,5 mg/ml + Glucose 5%
Compatible 100 UI/ml + InjectionMidazolam hydrochloride 5 mg/ml
InjectionHuman albumin Various
Compatible 250 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionHydralazine hydrochloride Antihypertensive
Compatible 20 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 50 mg/ml + InjectionCefoxitin sodium 100 mg/ml
InjectionInsulin Glucose-lowering
Incompatible 100 UI/ml + InjectionDopamine hydrochloride 3,2 mg/ml
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0,2 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionKetamine hydrochloride General anesthetic
Compatible 50 mg/ml + InjectionAlprostadil 500 µg/ml
Incompatible 50 mg/ml + InjectionAminophylline 25 mg/ml
Compatible 50 mg/ml + InjectionCiclosporin 50 mg/ml
Incompatible 50 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml
Compatible 50 mg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 50 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml
Compatible 50 mg/ml + InjectionIsoprenaline hydrochloride 0,2 mg/ml
Compatible 50 mg/ml + InjectionLorazepam 4 mg/ml
Compatible 50 mg/ml + InjectionNicardipine hydrochloride 0,2 mg/ml
Incompatible 50 mg/ml + InjectionNitroglycerin 5 mg/ml
Compatible 50 mg/ml + InjectionNorepinephrine bitartrate 1 mg/ml
Compatible 50 mg/ml + InjectionOndansetron hydrochloride 2 mg/ml
Compatible 50 mg/ml + InjectionPiperacillin sodium 200 mg/ml
Compatible 50 mg/ml + InjectionSalbutamol sulfate 1 mg/ml
Compatible 50 mg/ml + InjectionSufentanil citrate 0,05 mg/ml
Compatible 50 mg/ml + InjectionVasopressin 20 UI/ml
InjectionLevosimendan Various
Compatible 2.5 mg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 2,5 mg/ml + InjectionEpinephrine hydrochloride 1000 µg/ml
Compatible 2,5 mg/ml + InjectionFentanyl citrate 50 µg/ml
Compatible 2,5 mg/ml + InjectionHeparin sodium 100 UI/ml + Glucose 5%
Compatible 2,5 mg/ml + InjectionHydromorphone hydrochloride 10 mg/ml
Compatible 2,5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml
Compatible 2,5 mg/ml + InjectionMilrinone lactate 1 mg/ml
Compatible 2,5 mg/ml + InjectionMorphine sulfate 50 mg/ml
InjectionLorazepam Anxiolytic
Compatible 4 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionMagnesium sulfate Electrolyte
Incompatible 500 mg/ml + InjectionPotassium phosphate 3 mmol/ml
Incompatible 500 mg/ml + InjectionSodium Phosphate 3 mmol/ml
InjectionMeropenem Antibiotic
Compatible 50 mg/ml + InjectionAmikacin sulfate 250 mg/ml
Compatible 50 mg/ml + InjectionAztreonam 100 mg/ml
Compatible 50 mg/ml + InjectionCeftazidime 100 mg/ml
Compatible 50 mg/ml + InjectionTobramycin sulfate 40 mg/ml
InjectionMicafungin Antifungal
Incompatible 20 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + InjectionHeparin sodium 100 UI/ml
Compatible 5 mg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + InjectionAlprostadil 500 µg/ml
Compatible 1 mg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 1 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml
Compatible 1 mg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionMorphine sulfate Analgesic
Compatible 50 mg/ml + InjectionLevosimendan 2,5 mg/ml
InjectionN-acetylcysteine Antidote
Compatible 200 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionNicardipine hydrochloride Vasodilator
Compatible 0,2 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
Compatible 1 mg/ml + InjectionSufentanil citrate 0,05 mg/ml
InjectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionOxytocin Various
Incompatible 10 UI/ml + InjectionRemifentanil hydrochloride 1000 µg/ml
InjectionPenicillin G sodium Antibiotic
Compatible 0,5 MUI/ml + InjectionDexmedetomidine 100 µg/ml
InjectionPhentolamine mesylate Vasodilator
Compatible 5 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionPotassium chloride Electrolyte
Compatible 2 mEq/l + InjectionAmpicillin sodium 100 mg/ml
Compatible 2 mEq/l + InjectionDimenhydrinate 10 mg/ml
InjectionPotassium phosphate Electrolyte
Incompatible 3 mmol/ml + InjectionMagnesium sulfate 500 mg/ml
Incompatible 3 mmol/ml + InjectionSodium bicarbonate 84 mg/ml
InjectionRemifentanil hydrochloride Analgesic
Incompatible 1000 µg/ml + InjectionOxytocin 10 UI/ml
InjectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + InjectionDexmedetomidine 100 µg/ml
Compatible 1 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
InjectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + InjectionPotassium phosphate 3 mmol/ml
InjectionSodium Phosphate Electrolyte
Incompatible 3 mmol/ml + InjectionMagnesium sulfate 500 mg/ml
InjectionSufentanil citrate Analgesic
Compatible 0,05 mg/ml + InjectionKetamine hydrochloride 50 mg/ml
Compatible 0,05 mg/ml + InjectionNorepinephrine bitartrate 1 mg/ml
InjectionThiamine hydrochloride Vitamin
Compatible 100 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + InjectionMeropenem 50 mg/ml
InjectionTranexamic acid Anti-bleeding
Compatible 100 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionValproic acid Antiepileptic
Compatible 100 mg/ml + InjectionDexmedetomidine 100 µg/ml
InjectionVasopressin Hormone
Compatible 20 UI/ml + InjectionKetamine hydrochloride 50 mg/ml

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