Last update :
22/01/2021
Anticancer drug   Methotrexate sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Incompatibilities Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Abitrexate Republic of South Africa
Antifolan Romania
Biometrox Brazil
Ebetrex Switzerland
Ebetrexate Austria
Emthexat Turkey
Emthexate Belgium, Netherlands, Republic of South Africa, Spain
Ledertrexate Belgium, France, Luxembourg, Morocco
Maxtrex Great Britain
Metex Norway
Methoblastin Republic of South Africa
Methotrexate France
Metoject Denmark, Finland, France, Great Britain, Netherlands, Spain, Sweden, Switzerland
Trexan Finland
References   Injection   References : Methotrexate sodium  
Type Publication
31 Journal Zhang Y, Xu QA, Trissel LA, Gilbert DL.
Physical and chemical stability of methotrexate sodium, cytarabine, and hydrocortisone sodium succinate in Elliott’s B solution.
Hosp Pharm 1996 ; 31: 965-970.
57 Journal Mayron D, Gennaro AR.
Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Am J Health-Syst Pharm 1996 ; 53: 294-304.
110 Journal Vincke BJ, Verstraeten AE, El Eini DID, Mc Carthy TM.
Extended stability of 5-fluorouracil and methotrexate solutions in PVC containers.
Int J Pharm 1989 ; 54: 181-189.
145 Journal Lorillon P, Corbel JC, Mordelet MF, Basle B, Guesnier LR.
Photosensibility of 5-fluorouracile and methotrexate in translucent or opaque perfusers.
J Pharm Clin 1992 ; 11: 285-295.
150 Journal Aujoulat P, Coze C, Braguer D, Raybaud C.
Physicochemical compatibility of methotrexate with co-administered drugs during cancer chemotherapy regimens.
J Pharm Clin 1993 ; 12: 31-35.
162 Journal Benaji B, Dine T, Goudaliez F, Luyckx M, Brunet C, Mallevais ML, Gressier B, Cazin M, Cazin JC.
Compatibility study of methotrexate with PVC bags after repackaging into two types of infusion admixtures.
Int J Pharm 1994 ; 105: 83-87.
184 Journal Stewart JT, Warren FW, King DT, Fox JL.
Stability of ondansetron hydrochloride and five antineoplasic medications.
Am J Health-Syst Pharm 1996 ; 53: 1297-1300.
300 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1287-1292.
301 Journal Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1295-1300.
431 Journal McRae MP, King JC.
Compatibility of antineoplastic, antibiotic and corticosteroid drugs in intravenous admixtures.
Am J Hosp Pharm 1975 ; 33: 1010-1013.
491 Journal Turowski RC, Durthaler JM.
Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2181-2184.
739 Journal Cradock JC, Kleinmann LM, Rahman A.
Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone sodium succinate.
Am J Hosp Pharm 1978 ; 35: 402-406.
763 Journal Cohen MH, Jonhson-Early A, Hood MA, McKenzie M, Citron ML, Jaffe N, Krasnow SH.
Drug precipitation within IV tubing : A potential hazard of chemotherapy administration.
Cancer Treat Rep 1985 ; 69: 1325-1326.
859 Journal Karlsen J, Thonnesen HH, Olsen IR, Sollien AH, Skobba TJ.
Stability of cytotoxic intravenous solutions subjected to freeze-thaw treatment.
Nor Pharm Acta 1983 ; 45: 61-67.
978 Journal Dick DM, Woloschuk DMM.
Methotrexate and cytarabine for intrathecal administration.
Can J Hosp Pharm 1994 ; 47: 147.
1021 Journal Dyvik O, Grislingaas AL, Tonnesen HH, Karlsen J.
Methotrexate in solutions - A stability test for the hospital pharmacy.
J Clin Hosp Pharm 1986 ; 11: 343-348.
1028 Journal Cheung YW, Vishnuvajjala BR, Flora KP.
Stability of cytarabine, methotrexate sodium, and hydrocortisone sodium succinate admixtures.
Am J Hosp Pharm 1984 ; 41: 1802-1806.
1088 Journal Johnston A, McKenzie MA, Krasnow SH, Hood MA, Cohen MH.
Drug trapping in intravenous infusion side arms.
JAMA 1984 ; 252: 2392.
1155 Journal Wright MP, Newton JM.
Stability of methotrexate injection in prefilled plastic disposable syringes.
Int J Pharm 1988 ; 45: 237-244.
1158 Journal McElnay JC, Elliott DS, Cartwright-Shamoon J, D?Arcy PF.
Stability of methotrexate and vinblastine in burette administration sets.
Int J Pharm 1988 ; 47: 239-247.
1423 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1469 Journal Jacolot A, Arnaud P, Lecompte D, Alamercery S, Caroff E, Naveau C, Guillot T, Bousselet M, Brion F.
Stability and compatibility of 2.5 mg/ml methotrexate solution in plastic syringes over 7 days.
Int J Pharm 1996 ; 128: 283-286.
1501 Journal Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
Int J Pharm 1999 ; 185: 113-121.
1520 Manufacturer Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1661 Journal Trissel LA, King KM, Zhang Y, Wood AM.
Physical and chemical stability of methotrexate, cytarabine, and hydrocortisone in Elliott’s B Solution for intrathecal use.
J Oncol Pharm Practice 2002 ; 8: 27-32.
3275 Journal D?Hondt M, Vangheluwe E, Van Dorpe S, Boonen J, Bauters T, Pelfrene B, Vandenbroucke J, Robays H, De Spiegeleer B
Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate
Am J Health-Syst Pharm 2012 ; 69: 232-240.
3474 Manufacturer Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3580 Manufacturer Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3637 Manufacturer Methotrexate (Methotrexate solution for injection®) - Summary of Product Characteristics
Hameln Pharmaceuticals 2014
3670 Journal Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
3731 Journal Chatterji D.C, Gallelli J.F.
Thermal and photolytic decomposition of methotrexate in aqueous solutions.
J Pharm Sci 1978 ; 67, 4: 526-530.
3980 Journal Nissen K.B, Jorgensen L.B, Berg D.L, Andersen G.
Stability study of methotrexate in 0.9% sodium chloride injection and 5% dextrose injection with limit tests for impurities.
Am J Health-Syst Pharm 2017 ; 74,9: e211-e223
4154 Manufacturer Bleomycin sulfate- Summary of Product Characteristics
Accord Health Care 2018

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