Last update :
22/01/2021
References   References 31  
Type : Journal PC : 0.0006830601092896 

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Xu QA, Trissel LA, Gilbert DL.
Title : Physical and chemical stability of methotrexate sodium, cytarabine, and hydrocortisone sodium succinate in Elliott’s B solution.
Reference : Hosp Pharm ; 31: 965-970. 1996

Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A+ Methotrexate sodium
Level of evidence A+ Cytarabine
Level of evidence B+ Hydrocortisone sodium succinate
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Methotrexate sodium
Stability defined as 95% of the initial concentrationMethotrexate sodium
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Cytarabine
Stability defined as 95% of the initial concentrationCytarabine
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Hydrocortisone sodium succinate
Stability defined as 90% of the initial concentrationHydrocortisone sodium succinate
Other methods : 
Comments : 
No comments for the degradation productsMethotrexate sodium
No comments for the degradation productsCytarabine
No comments for the degradation productsHydrocortisone sodium succinate

List of drugs
InjectionCytarabine Anticancer drug
Stability in solutions Glass Elliott’s B solution 3 mg/ml 23°C Not specified
48 Hour
Stability in solutions Glass Elliott’s B solution 3 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 3 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 3 mg/ml 4°C Protect from light
48 Hour
InjectionHydrocortisone sodium succinate Anti-inflammatory
Stability in solutions Glass Elliott’s B solution 2 mg/ml 23°C Not specified
24 Hour
Stability in solutions Glass Elliott’s B solution 2 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 2 mg/ml 23°C Not specified
24 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 2 mg/ml 4°C Protect from light
48 Hour
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Glass Elliott’s B solution 2 mg/ml 23°C Not specified
48 Hour
Stability in solutions Glass Elliott’s B solution 2 mg/ml 4°C Not specified
48 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 2 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polypropylen Syringe Elliott’s B solution 2 mg/ml 4°C Protect from light
48 Hour

  Mentions Légales