Last update :
22/01/2021
References   References 859  
Type : Journal

Research teams : Oslo - The Norwegian Radium Hospital, Pharmacy Department
Authors : Karlsen J, Thonnesen HH, Olsen IR, Sollien AH, Skobba TJ.
Title : Stability of cytotoxic intravenous solutions subjected to freeze-thaw treatment.
Reference : Nor Pharm Acta ; 45: 61-67. 1983

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No comments for the degradation products

List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,4 mg/ml -20°C Protect from light
30 Day
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 mg/ml -20°C Protect from light
30 Day

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