Last update :
21/01/2021
References   References 110  
Type : Journal
Web link : http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7W-47557CR-1XW&_user=10&_coverDate=09%2F15%2F1989&_rdoc=1&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235069%231989%23999459996%23356578%23FLP%23display%23Volume)&_cdi=5069&_sort=d&_docanchor

Research teams : Nivelles - Baxter R&D Europe
Authors : Vincke BJ, Verstraeten AE, El Eini DID, Mc Carthy TM.
Title : Extended stability of 5-fluorouracil and methotrexate solutions in PVC containers.
Reference : Int J Pharm ; 54: 181-189. 1989

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionFluorouracil Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
91 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
91 Day
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 1,25 & 12,5 mg/ml 2-8°C Protect from light
105 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1,25 & 12,5 mg/ml 2-8°C Protect from light
105 Day

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