Last update :
21/01/2021
References   References 1469  
Type : Journal

Research teams : Paris - Hôpital Robert Debré, Service pharmacie
Authors : Jacolot A, Arnaud P, Lecompte D, Alamercery S, Caroff E, Naveau C, Guillot T, Bousselet M, Brion F.
Title : Stability and compatibility of 2.5 mg/ml methotrexate solution in plastic syringes over 7 days.
Reference : Int J Pharm ; 128: 283-286. 1996

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products

List of drugs
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polypropylen Syringe None 2,5 mg/ml 25°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe None 2,5 mg/ml 4°C Protect from light
7 Day

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